의도치 않은 체중 감소는 암 위험 신호…의사 상담받아야

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"의도치 않은 체중 감소는 암 위험 신호…의사 상담받아야"

최근 2년간 체중이 의도치 않게 10% 이상 감소한 경우 상부 위장관 암 등 암 위험이 높다는 연구 결과가 나왔습니다.
연구팀은 이는 암 위험 신호라며 의사 상담을 권고했습니다.

본 원에서는 위 기사의 논문을 모든 PC에서 검색해 보실 수 있습니다.

본 원에서는 2024년부터 AMA를 구독하고 있으며, AMA에 JAMA Pediatrics가 포함됩니다.

논문 제목 : Cancer Diagnoses After Recent Weight Loss

저자 : Qiao-Li Wang, MD, PhD1,2; Ana Babic, PhD1; Michael H. Rosenthal, MD, PhD3,4; et al

출처 : JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869.

논문  ☞ https://jamanetwork.com/journals/jama/fullarticle/2814132

        ☞ https://pubmed.ncbi.nlm.nih.gov/38261044/

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American Medical Association은 KMLA 컨소시엄을 통해서 구독하며, 구독 기간은 2024년 1월1일 부터 12월31일까지입니다.

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JAMA : The Journal of the American Medical Association  ☞ http://jama.jamanetwork.com

JAMA Dermatology ☞ http://archderm.jamanetwork.com
JAMA Internal Medicine ☞ http://archinte.jamanetwork.com
JAMA Neurology ☞ http://archneur.jamanetwork.com
JAMA Ophthalmology ☞ http://archopht.jamanetwork.com
JAMA Otolaryngology-Head & Neck Surgery ☞ http://archotol.jamanetwork.com
JAMA Pediatrics ☞ http://archpedi.jamanetwork.com
JAMA Psychiatry ☞ http://archpsyc.jamanetwork.com
JAMA Surgery ☞ http://archsurg.jamanetwork.com

※매년 이용 통계를 참고하여 구독을 유지 혹은 유보할 수 있습니다.

Abstract

Importance : Weight loss is common in primary care. Among individuals with recent weight loss, the rates of cancer
during the subsequent 12 months are unclear compared with those without recent weight loss.

Objective : To determine the rates of subsequent cancer diagnoses over 12 months among health professionals with
weight loss during the prior 2 years compared with those without recent weight loss.

Design, setting, and participants: Prospective cohort analysis of females aged 40 years or older from the Nurses' Health Study
who were followed up from June 1978 until June 30, 2016, and males aged 40 years or older from the Health Professionals
Follow-Up Study who were followed up from January 1988 until January 31, 2016.

Exposure: Recent weight change was calculated from the participant weights that were reported biennially.
The intentionality of weight loss was categorized as high if both physical activity and diet quality increased, medium if only 1 increased,
and low if neither increased.

Main outcome and measures: Rates of cancer diagnosis during the 12 months after weight loss.

Results: Among 157 474 participants (median age, 62 years [IQR, 54-70 years]; 111 912 were female [71.1%];
there were 2631 participants [1.7%] who self-identified as Asian, Native American, or Native Hawaiian; 2678 Black participants [1.7%];
and 149 903 White participants [95.2%]) and during 1.64 million person-years of follow-up, 15 809 incident cancer cases were
identified (incident rate, 964 cases/100 000 person-years). During the 12 months after reported weight change,
there were 1362 cancer cases/100 000 person-years among all participants with recent weight loss of greater than 10.0% of
body weight compared with 869 cancer cases/100 000 person-years among those without recent weight loss
(between-group difference, 493 cases/100 000 person-years [95% CI, 391-594 cases/100 000 person-years]; P < .001).
Among participants categorized with low intentionality for weight loss, there were 2687 cancer cases/100 000 person-years for
those with weight loss of greater than 10.0% of body weight compared with 1220 cancer cases/100 000 person-years for those
without recent weight loss (between-group difference, 1467 cases/100 000 person-years
[95% CI, 799-2135 cases/100 000 person-years]; P < .001). Cancer of the upper gastrointestinal tract (cancer of the esophagus,
stomach, liver, biliary tract, or pancreas) was particularly common among participants with recent weight loss;
there were 173 cancer cases/100 000 person-years for those with weight loss of greater than 10.0% of body weight compared
with 36 cancer cases/100 000 person-years for those without recent weight loss (between-group difference,
137 cases/100 000 person-years [95% CI, 101-172 cases/100 000 person-years]; P < .001).

Conclusions and relevance: Health professionals with weight loss within the prior 2 years had a significantly higher risk of cancer
during the subsequent 12 months compared with those without recent weight loss. Cancer of the upper gastrointestinal tract was
particularly common among participants with recent weight loss compared with those without recent weight loss.