[펌]미국 표준 치료법

<div class="post_tit_area" style="margin: 0px 74px; padding: 36px 0px 0px;"><a class="_categoryName" style="color: rgb(41, 205, 19); text-decoration: none; cursor: pointer; -webkit-tap-highlight-color: rgba(0, 0, 0, 0.1);" xxonclick="nclk(this, 'pst.board', '', '');" href="http://m.blog.naver.com/PostList.nhn?blogId=colus3th&categoryNo=108&logCode=0&categoryName=01.+%ED%9D%91%EC%83%89%EC%A2%85%EC%9D%98+%EC%9D%B4%ED%95%B4+">01. 흑색종의 이해</a><div class="tit_area " style="padding-right: 55px; position: relative;"><h3 class="tit_h3" style="margin: 0px; padding: 0px; color: rgb(22, 22, 22); line-height: 1.3em; font-family: AppleSDGothicNeo-Bold; font-size: 2.14em; font-weight: 600; -ms-word-break: break-all;">흑색종의 이해-01 : 2014년 미국 흑색종 표준 치료요법</h3><a class="btn_reply _comment_count" id="_comment_count" style="padding: 5px 6px 0px; border-radius: 3px; border: 1px solid rgb(209, 209, 209); top: 6px; height: 22px; text-align: center; right: 0px; color: rgb(41, 205, 19); text-decoration: none; display: block; 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font-size: 14px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; border-collapse: collapse; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;' border="1" cellspacing="0" cellpadding="0"><tbody><tr style="height: 28.6pt;"><td width="615" style="background: rgb(148, 54, 52); margin: 0px; padding: 0cm 5.4pt; border: 1px solid windowtext; width: 461.2pt;" colspan="2">제안된 치료요법 (Preferred Regimens)</td></tr><tr><td width="177" style="background: rgb(242, 219, 219); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">치료약물</td><td width="438" style="background: rgb(242, 219, 219); border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt;">치료요법</td></tr><tr style="height: 41.85pt;"><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">예보이 (Yervoy®)(이필리무맙, Ipilimumab)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1일차 : 이필리무맙, 3mg/kg, 정맥주사<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 3주마다 반복투여 (총 4-싸이클)</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">젤보라프 (Zelboraf®)(베뮤라페닙, Vemurafenib)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 베뮤라페닙, 960mg, 경구투여, 1일 2회<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• B-RAF, V600E 변이가 확인된 환자<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 병기가 지속될 때 까지 지속투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">타핀라 (Tafinlar®)(다브라페닙, Dabrafenib)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 다브라페닙, 150mg, 경구투여, 1일 2회<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• B-RAF, V600E 변이가 확인된 환자<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 병기가 지속될 때 까지 지속투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">다브라페닙 +트라메티닙(Dabrafenib+Trametinib)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 다브라페닙, 150mg, 경구투여, 1일 2회  + 트라메티닙, 2mg, 경구투여, 1일 1회<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• B-RAF, V600E/K 변이가 확인된 환자<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 병기가 지속될 때 까지 지속투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">고용량 인터루킨-2(High-Dose IL-2)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1–5일차: 인터루킨-2, 22mcg/kg (360,000 IU/kg),<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>33mcg/kg (540,000 IU/kg), 36mcg/kg (600,000 IU/kg),<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>또는 44mcg/kg (720,000mcg/kg), 8시간 이상 정맥투여<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 14회 이상 투여</td></tr><tr style="height: 33.05pt;"><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">그외</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 임상 진행용 약물 가능</td></tr><tr style="height: 29.55pt;"><td width="615" style="background: rgb(148, 54, 52); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 461.2pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;" colspan="2">그외 치료요법 (Other Active Regimens)</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">메키니스트 (Mekinist®)(트라메티닙, Trametinib)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 트라메티닙, 2mg, 경구투여, 1일 1회<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• B-RAF, V600E 변이가 확인된 환자<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 병기가 지속될 때 까지 지속투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">글리벡 (Gleevec®)(이메티닙, Imatinib)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 이메티닙, 400mg, 경구투여, 1일 2회<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• c-Kit 변이가 확인된 환자<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 병기가 지속될 때 까지 지속투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">다카바진(Dacarbazine)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1일차: 다카바진, 2–4.5mg/kg/day, 10일간 정맥투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 4주마다 반복투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>또는 (OR)<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-5일차: 다카바진, 250mg/m2/day, 정맥투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 3주마다 반복투여.</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">알부민-파크리탁셀(Albumin-bound paclitaxel)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• Nab-paclitaxel, 100mg/m2 (이전 항암요법 투여환자) 또는<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>150mg/m2 (<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>이전 항암요법을 받지 않은 환자), 정맥투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매주마다 반복투여 (총 3-4 싸이클 투여)</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">다카바진+시스플라틴+빈블라스틴(Dacarbazine + cisplatin +Vinblastine)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1, 22일차: 다카바진, 800mg/m2, 정맥투여, +<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-4일차, 22-25일차: 시스플라틴, 20mg/m2, 정맥투여,<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>  + <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>빈블라스틴 2mg/m2, 정맥투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 3주마다 반복투여 (총 2-싸이클 투여).<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>또는 (OR)<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1일차: 다카바진 800mg/m2, 정맥투여, +<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-4일차: 시스플라틴 20mg/m2, 정맥투여,<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>+ <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>빈블라스틴 1.2mg/m2, 정맥투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 3주마다 반복투여 (최대 4-싸이클 투여).<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>또는 (OR)<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1일차: 다카바진 800mg/m2, 정맥투여 +<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-4일차: 시스플라틴 20mg/m2, 정맥투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>+ <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>빈블라스틴, 1.6mg/m2, 정맥투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>+ <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>인터루킨-2, 9×106 IU/m2, 4일 이상 정맥투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>+ <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>이터페론-알파, 5×106 U/m2, 5일 동안 피하투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 3주마다 반복투여 (최대 6-싸이클 투여)</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">다카바진+시스플라틴+파크리탁셀(Dacarbazine + paclitaxel + cisplatin)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1일차: 다카바진 800mg/m2, 정맥투여 +<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-4일차: 시스플라틴 20mg/m2, 정맥투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-8일차: 파크리탁셀, 100mg/m2, <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>정맥투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">저용량 인터루킨-2+ GM-CSF(Low-dose interleukin-2 (IL-2) + GM-CSF)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-5일차: 인터루킨-2, 1 million IU/m2/day, 피하투여, +<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1-14일차: GM-CSF, 125mcg/m2/day, 피하투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 4주마다 반복투여 (총 12-싸이클 투여)<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>*** GM-CSF; granulocyte macrophage-stimulating factor<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>   (<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>과립대식세포 집락자극인자 수용체)</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">파크리탁셀+카보플라틴(Paclitaxel + carboplatin)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 1, 8 ,15일차: 파크리탁셀, 100mg/m2, <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>정맥투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>+ <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>카보플라틴, AUC=2, 정맥투여.<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 4주마다 반복투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 병기가 진행될 때까지 지속투여</td></tr><tr><td width="177" valign="top" style="background: rgb(238, 236, 225); border-style: none solid solid; border-color: rgb(0, 0, 0) windowtext windowtext; margin: 0px; padding: 0cm 5.4pt; width: 133pt; border-image-source: none; border-image-slice: initial; border-image-width: initial; border-image-outset: initial; border-image-repeat: initial;">파크리탁셀+카보플라틴± 넥사바 (Nexavar®)(Paclitaxel + carboplatin ±Sorafenib)</td><td width="438" valign="top" style="border-style: none solid solid none; border-color: rgb(0, 0, 0) windowtext windowtext rgb(0, 0, 0); margin: 0px; padding: 0cm 5.4pt; width: 328.2pt; background-color: transparent;"><span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• Day 1: 카보플라틴, AUC=6, 정맥투여<span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>+ 파크리탁셀, 225mg/m2, <span style="color: rgb(0, 0, 0); line-height: 22px !important; font-size: 11pt;" _foo='color: rgb(0, 0, 0); font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>정맥투여<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 2-19일차: 소라페닙, 400mg, 경구투여, 1일 2회<span style="line-height: 22px !important; font-size: 11pt;" _foo='font-size: 11pt; mso-ascii-font-family: "맑은 고딕"; mso-hansi-font-family: "맑은 고딕"; mso-ascii-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast;'>• 매 3주마다 반복투여</td></tr></tbody></table><p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" _foo="margin: 0cm 0cm 0pt; line-height: normal;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" _foo="margin: 0cm 0cm 0pt; line-height: normal;">미국 기준이며, 유럽과 그외 국가에서는 다소 차이를 보일 수 있습니다.<p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" _foo="margin: 0cm 0cm 0pt; line-height: normal;">환우분들께 도움이 되셨으면 합니다.<p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" _foo="margin: 0cm 0cm 0pt; line-height: normal;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"> <p style="margin: 0px; padding: 0px; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: normal; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" _foo="margin: 0cm 0cm 0pt; line-height: normal;">-아영아빠 올림- </div></div>