🔴알벤다졸 펜벤다졸 메벤다졸 구충제 암세포를 박멸하다 (논문자료)

[Gloria]

🔴알벤다졸 펜벤다졸 메벤다졸 구충제 암세포를 박멸하다 (논문자료)
번역자 검색 논문 제시:  2024.03.20. 구충제 효과 리서치

현재 구충제를 복용하는 방법이 두가지가 존재하며 펜벤다졸이나 메벤다졸 알벤다졸의
성분은 99% 유사하기 때문에 구하기 용이한 제품을 선택 하는 것을 추천한다.
그리고 과다 복용은 부작용이 초래할 수 있기 때문에 올바르게 복용해야 한다.
구충제가 암세포를 어떻게 억제를 하는지 근거를 통해 정리하겠습니다.

🔴펜벤다졸은 중간 정도의 미세소관 불안정화제 역할을 하며 

여러 세포 경로를 조절하여 암세포 사멸을 유발합니다.

🍁추론: 
암 이외의 질환에 대해 이미 임상적으로 승인되었거나 실험적으로 테스트되었지만 

악성 세포에 대해 이전에 인식되지 않은 세포 독성을 가지고 있는 것으로 밝혀진 

약물은 적합한 항암 후보로 작용할 수 있습니다. 벤즈이미다졸 화합물인 

메틸 N-(6-페닐설파닐-1H 벤즈이미다졸-2-일) 카바메이트[펜벤다졸, FZ]는 효율적인 

항증식 활성을 갖는 안전하고 저렴한 구충제입니다. 

이전 연구에서 우리는 프로테아솜 기능의 손상으로 인해 부분적으로 유발된 FZ의 

강력한 성장 억제 활동을 보고했습니다. 여기에서 우리는 FZ가 포유동물 튜불린에 

대해 적당한 친화력을 보여주고 마이크로몰 농도에서 인간 암세포에 세포독성을 

발휘한다는 것을 보여줍니다. 동시에, 이는 p53의 미토콘드리아 전위를 유발하고 

포도당 흡수, GLUT 수송체의 발현 및 대부분의 암세포가 번성하는 핵심 분해 효소인 

헥소키나제(HK II)를 효과적으로 억제했습니다. 이는 쥐에게 약물을 경구 투여했을 때 

nu/nu 쥐 모델에서 인간 이종이식편의 성장을 차단했습니다. 이전 데이터와 함께 

결과는 FZ가 항신생물 활성을 나타내는 새로운 미세소관 간섭제이며 암세포의 

효과적인 제거를 유도하는 다중 세포 경로에 대한 효과 때문에 잠재적인 치료제로 

평가될 수 있음을 시사합니다.

🍁논문자료;

https://www.nature.com/articles/s41598-018-30158-6

Fenbendazole acts as a moderate microtubule

destabilizing agent and causes cancer cell death

by modulating multiple cellular pathways

Abstract

Drugs that are already clinically approved or experimentally tested for conditions other than cancer, but are found to possess previously unrecognized cytotoxicity towards malignant cells, may serve as fitting anti-cancer candidates. Methyl N-(6-phenylsulfanyl-1H benzimidazol-2-yl) carbamate [Fenbendazole, FZ], a benzimidazole compound, is a safe and inexpensive anthelmintic drug possessing an efficient anti-proliferative activity. In our earlier work, we reported a potent growth-inhibitory activity of FZ caused partially by impairment of proteasomal function. Here, we show that FZ demonstrates moderate affinity for mammalian tubulin and exerts cytotoxicity to human cancer cells at micromolar concentrations. Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression‎ of GLUT transporters as well as hexokinase (HK II) - a key glycolytic enzyme that most cancer cells thrive on. It blocked the growth of human xenografts in nu/nu mice model when mice were fed with the drug orally. The results, in conjunction with our earlier data, suggest that FZ is a new microtubule interfering agent that displays anti-neoplastic activity and may be eval‎uated as a potential therapeutic agent because of its effect on multiple cellular pathways leading to effective elimination of cancer cells.

2018년 8월에 펜벤다졸과 암세포에 관한 논문 입니다.

출처: https://rightchune.tistory.com/3 [에디터 센딕:티스토리]