Re: 환자혁명 - 칼슘의 다양한 기능(당뇨, 암, 고혈압 등)

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미량원소 치유의학의 세계

beyond reason

칼슘은 축구팀의 에이스 같은 존재, 실력은 출중한데 팀워크를 깨는 ..

칼슘은 결핍이 쉽지 않은데 결핍이 많음.

골다공증은 칼슘부족이 원인이 아님. 칼슘만 먹어서는 골다공증 개선이 되지 않음. 

칼슘의 흡수와 활용이 문제임. 

칼슘의 기능

세포와 세포사이에서 신호를 전달하는 역할

세포외 이온화 칼슘이 세포내 칼슘보다 1만배 많음. 뼈에 99% 존재함.

세포내 칼슘이 많다는 것은 동맥경화, 고혈압, 신장결석, 요로결석, 담석 등

칼슘과 비타민 D - 당뇨에 중요한 역할

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Abstract

Context

Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes (t2DM).

Evidence Acquisition and Analyses

MEDLINE review through January 2007 for observational studies and clinical trials in adults with outcomes related to glucose homeostasis. When data was available to combine, meta-analyses were performed and summary odds ratios (OR) are presented.

Evidence Synthesis

Observational studies show a relatively consistent association between low vitamin D status, calcium or dairy intake and preval‎ent t2DM or metabolic syndrome (OR [95% CI]: t2DM preval‎ence, 0.36 [0.16 – 0.80] among non-blacks for highest vs. lowest 25-OHD; metabolic syndrome preval‎ence, 0.71 [0.57 – 0.89] for highest vs. lowest dairy intake). There are also inverse associations with incident t2DM or metabolic syndrome (OR [95% CI]: t2DM incidence, 0.82 [0.72 – 0.93] for highest vs. lowest combined vitamin D and calcium intake; 0.86 [0.79 – 0.93] for highest vs. lowest dairy intake). Evidence from trials with vitamin D and/or calcium supplementation suggests that combined vitamin D and calcium supplementation may have a role in the prevention of t2DM only in populations at high risk (i.e. glucose intolerance). The available evidence is limited because most observational studies are cross-sectional and did not adjust for important confounders while intervention studies were short in duration, included few subjects, used a variety of formulations of vitamin D and calcium or did post-hoc analyses.

Conclusions

The Role of Vitamin D and Calcium in type 2 diabetes. A systematic Review and Meta-Analysis^*

ANASTASSIOS G. PITTAS, MD, MSc,¹ JOSEPH LAU, MD,² FRANK HU, MD,³ and BESS DAWSON-HUGHES, MD^1,4

Author information Copyright and License information Disclaimer

Abstract

Context

Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes (t2DM).

Evidence Acquisition and Analyses

MEDLINE review through January 2007 for observational studies and clinical trials in adults with outcomes related to glucose homeostasis. When data was available to combine, meta-analyses were performed and summary odds ratios (OR) are presented.

Evidence Synthesis

Observational studies show a relatively consistent association between low vitamin D status, calcium or dairy intake and preval‎ent t2DM or metabolic syndrome (OR [95% CI]: t2DM preval‎ence, 0.36 [0.16 – 0.80] among non-blacks for highest vs. lowest 25-OHD; metabolic syndrome preval‎ence, 0.71 [0.57 – 0.89] for highest vs. lowest dairy intake). There are also inverse associations with incident t2DM or metabolic syndrome (OR [95% CI]: t2DM incidence, 0.82 [0.72 – 0.93] for highest vs. lowest combined vitamin D and calcium intake; 0.86 [0.79 – 0.93] for highest vs. lowest dairy intake). Evidence from trials with vitamin D and/or calcium supplementation suggests that combined vitamin D and calcium supplementation may have a role in the prevention of t2DM only in populations at high risk (i.e. glucose intolerance). The available evidence is limited because most observational studies are cross-sectional and did not adjust for important confounders while intervention studies were short in duration, included few subjects, used a variety of formulations of vitamin D and calcium or did post-hoc analyses.

Conclusions

Vitamin D and calcium insufficiency may negatively influence glycemia while combined supplementation with both nutrients may be beneficial in optimizing glucose metabolism.

칼슘, 비타민 D - 암,  apoptosis에 칼슘이 관여

Anticancer Res. 2009 Sep;29(9):3687-98.

Calcium, vitamin D and cancer.

Peterlik M1, Grant WB, Cross HS.

Author information

1

Department of Pathophysiology, Medical University Vienna, A-1090 Vienna, Austria. meinrad.peterlik@meduniwien.ac.at

Abstract

A low vitamin D status and inadequate calcium intake are important risk factors for various types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D3 photoproduction in the skin found a highly significant inverse association between UV-B and mortality in fifteen types of cancer. Of these, colon, rectal, breast, gastric, endometrial, renal and ovarian cancer exhibit a significant inverse relationship between incidence and oral intake of calcium. In addition, lung and endometrial cancer as well as multiple myeloma are considered calcium and vitamin D sensitive. Studies on tissue-specific expression‎ of the CYP27B1-encoded 25-hdroxyvitamin D-1alpha-hydroxylase and of the extracellular calcium-sensing receptor (CaR) have led to an understanding how locally produced 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. 

Thus, impairment of antimitogenic, proapoptotic and prodifferentiating signaling from the 1,25(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency has been implicated in the pathogenesis of the aforementioned types of cancer. 1,25(OH)2D3 and calcium interact in modulating cell growth in different ways: (i) Signaling pathways from the VDR and the CaR converge on the same downstream elements, e.g. of the canonical Wnt pathway; (ii) high extracellular calcium modulates extrarenal vitamin D metabolism in favor of higher local steady-state concentrations of 1,25(OH)2D3; (iii) 1,25(OH)2D3 may up-regulate expression‎ of the CaR and thus augment CaR-mediated antiproliferative responses to high extracellular Ca2+. This can explain why combined supplementation is required for optimal chemoprevention of cancer by calcium and vitamin D.

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Abstract

The intracellular calcium ions (Ca²⁺) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca²⁺homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca²⁺ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca²⁺ channels, transporters and Ca²⁺-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward eval‎uation of the blockers, inhibitors or regulators for Ca²⁺ channels/transporters or Ca²⁺-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research into the understanding of cellular mechanisms underlying the regulation of Ca²⁺ signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca²⁺ 

Acta Pharm Sin B. 2017 Jan; 7(1): 3–17.

Published online 2016 Dec 13. doi: 10.1016/j.apsb.2016.11.001

PMCID: PMC5237760

PMID: 28119804

Targeting calcium signaling in cancer therapy

Chaochu Cui,^a,b Robert Merritt,^b,c Liwu Fu,^a and Zui Pan^b,c,d,⁎

Author information Article notes Copyright and License information Disclaimer

Abstract

The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward eval‎uation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research into the understanding of cellular mechanisms underlying the regulation of Ca2+ signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca2+ channels or transporters.

칼슘 - 결합조직, 연조직에 있다는 것은 ... calcific tendinitis. 요로결석, 담석

칼슘이 활용되지 못하면 문제가 됨

칼슘이 잘 이동, 활용하기 위해서 필요한 영양소

비타민 k, d, 비타민  C, E, 보론, 마그네슘 

Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health

Katarzyna Maresz, PhD

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Abstract

Inadequate calcium intake can lead to decreased bone mineral density, which can increase the risk of bone fractures. Supplemental calcium promotes bone mineral density and strength and can prevent osteoporosis. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. In contrast, vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls. Vitamin K, particularly as vitamin K2, is nearly nonexistent in junk food, with little being consumed even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could be a means of lowering calcium-associated health risks.

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Abstract

Inadequate calcium intake can lead to decreased bone mineral density, which can increase the risk of bone fractures. Supplemental calcium promotes bone mineral density and strength and can prevent osteoporosis. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. In contrast, vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls. Vitamin K, particularly as vitamin K2, is nearly nonexistent in junk food, with little being consumed even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 

비타민 d가 모자라면 칼슘 부족,

비타민 D는 스트레스에 의해서 발생하므로 꼭 해결해야

담즙부족 - 비타민 D 지용성비타민 흡수 장애를 일으킴. 지방을 소화하는 담즙이 잘 나와야

비타민 D 부족한 질환과 칼슘이 부족해서 발생하는 질병과 비슷함. 

체인 REACTION

비타민 K는 비타민 D와 함께 작용..

담석, 요로결석, 석회화 건염... 비타민 D, K를 복용하면 칼슘을 뼈로 이동시킴.

마그네슘도 칼슘이동에 중요한 역할

오메가 3 지방산은 칼슘을 피부로 옮겨줌.

칼슘 흡수를 방해함. 먹는시간을 달리

마그네슘 저녁에 복용

비타민 K, D, 칼슘은 점심식사와 함께

칼슘은 음식으로 섭취하는 것이 좋음.

탄산칼슘, 칼슘카보네이트는 광물질이므로 좋은 것이 아님. 시멘트를 먹는것과 같다.

음식 - 유기농 목초사육, 무항생제 치즈.. 연어, 정어리, 참께, 케일, 브로콜리 등