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Alutrat (No 1)
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Alutrat is an effective and safe astringent, without any
of the inconveniences of chlorydrates and other
inorganic salts of aluminium.
On the basis of the foregoing studies we have looked for a
substance and a non-toxic formulation that is in accordance with
the requested dermatologic and cosmetic needs.
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Aluminium salts come up to our expectations better. We have
excluded the most common inorganic salts, as chloride,
hydroxychloride and sulphate because they are highly
ionisable and consequently they form suddenly
complexes with the epidermal proteins. So these salts
are irritant for the skin and, above certain concentrations, they
induce hydroxyadenitic inflammation. Besides, it has been shown
some formulations precipitating proteins are not astringent. Other
Authors demonstrated that the transmission electron microscopy
of aluminium chloridrate (ACH)-treated sweat glands indicated that
just as the duct leaves the epidermis, and passes through the
stratum corneum to the skin surface, its lumen is completely filled
with an electron-dense, amorphous material. This material, the
counter part of the morin fluorescence with regard to relative
location, is believed to be the plug, consisting of ACH or one of its
reaction products, responsible for sweat gland inhibition. In
contrast, untreated glands were patent and devoid of comparable
material. Morin Fluorescence microscopy of those glands revealed
that aluminium was present within the duct, generally as a solid
mass at the level of the stratum corneum.
Occasionally, some aluminium fluorescence was also observed in
the duct at the level of the upper epidermis. Fluorescence was
never observed in control (untreated) glands. Last we have seen a
fabrics corrosion where they touched the formulation. In
particular cellulose fabrics, like rayon and cotton,
are exposed to this attack.
Our experience and others on antiperspirant formulations led to
the synthesis of an experimentally highly competing and openly
less toxic salt.
It is an organic salt, less absorbed by the skin but with a high
power in modifying sweat gland activity. It operates without the
typical "impact" action of equiactive inorganic formulations. We
refer to hydroxyaluminium citrate, Alutrat, that shows all
advantages of aluminium derivatives, but does not produce any
significant toxic effect, not even bland.
Employment possibilities
The hydroxyaluminium citrate (Alutrat) not aggressive
action is used for antiperspirant formulations (sprays,
podalic detergents, skin dusting powders) for face
astringent lotions (tonics, masks, after-shave
lotions), and for special hygiene detergents.
According to experimental and clinic researches we came to the
conclusion that hydroxyaluminium citrate shows a
meaningful astringent action after sufficiently
prolonged skin application, either from the
physiological point of view, or for its capability of
eliciting a dose-dependent effect.