Re: Cancer Stem Cell

[애슐]

applying the principles of stem-cell biologyto cancer.pdf

cancer stem cell premises, promises and challenges.pdf

over the last decade, the notion that tumors are maintained by their own stem cells, the so-called cancer stem cells, has created great excitement in the research community. This review attempts to summarize the underlying concepts of this notion, to distinguish hard facts from beliefs and to define the future challenges of the field.

Central to the cancer stem cell(CSC) concept is the observation that not all cells in tumors are equal.

A major attraction of the CSC concept rests in the explanations it provides for several poorly understood clinical phenomena.

CSCs are tacitly believed to have acquired the molecular armaments of normal stem cell:

CSCs can renew themselves, and they are built to last a life-time, to be resilient to electromagnetic and chemical insults, to be able to slumber for prolonged periods of time and to colonize other parts of body.

Rare CSCs may be able to survive these therapeutic regimens, thus explaining why local recurrence is the almost-inevitable outcome of effective treatment of solid tumors by radiation or chemotherapy. Quiescent CSCs that have drifted to distant sites may be responsible for metastases that can appear that can appear many years after curative surgical treatment of a primary tumor.

Lstly, the CSC hypothesis promises the development of more effective treatments, aimed not at reducing tumor bulk, but rather at targeting the 'beating heart' of the tumor, the CSC

 cancer stem cell-마음,감정-전이 재발...