[인체 생리학] Glomerular Filtration

<TABLE cellSpacing=0 cellPadding=15 width="100%" border=0> <TBODY> <TR vAlign=top> <TD class=text id=clix_content style="PADDING-BOTTOM: 8px" width="100%" bgColor=#ffffff> <TABLE cellSpacing=0 cellPadding=0 width=700 align=center border=0> <TBODY> <TR> <TD width=700 colSpan=4><B><FONT color=black>Glomerular Filtration</FONT></B></TD></TR> <TR> <TD width=20>  </TD> <TD width=680 colSpan=3> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>glomerular membrane에서 혈액 여과 </TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640>  </TD></TR> <TR> <TD width=20>  </TD> <TD width=680 colSpan=3>1. Glomerular membrane</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640>  </TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=660 colSpan=2>1) Three layer</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=660 colSpan=2>  </TD></TR></TBODY></TABLE> <TABLE cellSpacing=0 cellPadding=0 align=center border=0> <TBODY> <TR> <TD vAlign=top align=middle> <IMG style="CURSOR: hand" height=331 src="https://img1.daumcdn.net/relay/cafe/original/?fname=http%3A%2F%2Fwww.jakphysiology.co.kr%2Fphysiology%2Fclass%2Fclass_img%2Fweek_14%2Fweek_14_05.jpg" width=320 border=0 [안내]태그제한으로등록되지않습니다-xx[안내]태그제한으로등록되지않습니다-xxonclick="MM_openBrWindow('zoom/zoom.asp?idx=05&week=14','zoom','width=680,height=665,resizable=yes,scrollbars=yes')"></TD></TR> <TR> <TD vAlign=top align=middle>  </TD></TR> <TR> <TD vAlign=top align=middle>[그림 14-5] </TD></TR> <TR> <TD vAlign=top align=middle>  </TD></TR></TBODY></TABLE> <TABLE cellSpacing=0 cellPadding=0 width=700 align=center border=0> <TBODY> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>a fine molecular sieve & negatively charged surface proteins help repel negatively charged plasma proteins </TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2>  </TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=640 colSpan=2> ① The wall of the glomerular capillaries</TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=620> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>single layer of endothelial cell </TD></TR> <TR> <TD vAlign=top width=20>- </TD> <TD>fenestrated capillaries : many large pores, retains the blood cells but permits H<SUB>2</SUB>O and solutes of small molecular dimension to filter (신체 다른 부위의 capillary보다 100배 큰 투과도)</TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2>  </TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=640 colSpan=2> ② Basement membrane (an acellular gelatinous layer)</TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=620> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD vAlign=top width=20>- </TD> <TD>act like a coarse sieve </TD></TR> <TR> <TD vAlign=top width=20>- </TD> <TD>collagen : structural strength</TD></TR> <TR> <TD vAlign=top width=20>- </TD> <TD>glycoprotein : 강한 -(negative) charge를 가지고 있어서, pore를 통해 plasma protein (alumin-the smallest of plasma proteins & negatively charged)이 여과되는 것을 반발하여 막는다. (보통 Bowman's capsule로 빠져나가는 albumin은 1%미만)</TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620>  </TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2>③ Inner layer of Bowman's capsule</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD vAlign=top width=20>- </TD> <TD>consists of podocytes </TD></TR> <TR> <TD vAlign=top width=20>- </TD> <TD>근접한 podocyte의 foot processes가 서로 얽히어 있고 그 사이의 노출된 좁은 부분을 filtration slit이라고 하는데 이 slit이 fluid 통로이다.</TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620>  </TD></TR> <TR> <TD width=20>  </TD> <TD width=680 colSpan=4>2. Force involved in glomerular filtration</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620>  </TD></TR></TBODY></TABLE> <TABLE cellSpacing=0 cellPadding=0 align=center border=0> <TBODY> <TR> <TD vAlign=top align=middle> <IMG style="CURSOR: hand" height=407 src="https://img1.daumcdn.net/relay/cafe/original/?fname=http%3A%2F%2Fwww.jakphysiology.co.kr%2Fphysiology%2Fclass%2Fclass_img%2Fweek_14%2Fweek_14_06.jpg" width=301 border=0 [안내]태그제한으로등록되지않습니다-xx[안내]태그제한으로등록되지않습니다-xxonclick="MM_openBrWindow('zoom/zoom.asp?idx=06&week=14','zoom','width=680,height=665,resizable=yes,scrollbars=yes')"></TD></TR> <TR> <TD vAlign=top align=middle>  </TD></TR> <TR> <TD vAlign=top align=middle>[그림 14-6] </TD></TR> <TR> <TD vAlign=top align=middle>  </TD></TR></TBODY></TABLE> <TABLE cellSpacing=0 cellPadding=0 width=700 align=center border=0> <TBODY> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=660 colSpan=3>1) Three physical forces</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620>  </TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2>① Glomerular capillary blood pressure</TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=620> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>major force </TD></TR> <TR> <TD width=20>- </TD> <TD>favors filtration (+55mmHg)</TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2>  </TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=640 colSpan=2>② Plasma-colloid osmotic pressure</TD></TR> <TR> <TD width=20 height=18> </TD> <TD width=20 height=18> </TD> <TD width=20 height=18> </TD> <TD width=20 height=18> </TD> <TD width=620 height=18> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>opposes filtration (-30mmHg) </TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2>  </TD></TR> <TR> <TD width=20> </TD> <TD width=20> </TD> <TD width=20> </TD> <TD width=640 colSpan=2>③ Bowman's capsule hydrostatic pressure</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>opposes filtration (-15mmHg) </TD></TR></TBODY></TABLE></TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=620>  </TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=660 colSpan=3>2) Net filtration pressure</TD></TR> <TR> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=20>  </TD> <TD width=640 colSpan=2> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD width=20>- </TD> <TD>favors filtration = 55 - (30 + 15) = 10 </TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></TD> <TD style="PADDING-LEFT: 0px" vAlign=top noWrap align=right> <xSCRIPT language=xxjavascript> function popupMyAvatar() { mname = "%B8%B6%BF%EE%C6%BE"; rurl = "http://cafe.daum.net/reload.html"; url = "http://mall.avatar.daum.net/cgi-bin/MyAvatar?TYPE=POPUP&MNAME="+mname+"&URL="+rurl; window.open(url, '', 'toolbar=0,status=0,width=610,height=402,scrollbars=1'); } //친구 앨범 function popupAlbum() { mname = "%B8%B6%BF%EE%C6%BE"; rurl = "http://cafe.daum.net/reload.html"; url = "http://mall.avatar.daum.net/cgi-bin/ViewFriendAlbum?TYPE=POPUP&EUSERID=p9.U1TCiq5Q0&MNAME="+mname+"&URL="+rurl; window.open(url, '', 'toolbar=0,status=0,width=610,height=402,scrollbars=1'); } //찜목록 function popupZim() { url = "http://mall.avatar.daum.net/cgi-bin/ViewFriendWishList?TYPE=POPUP&EUSERID=p9.U1TCiq5Q0&MNAME=%B8%B6%BF%EE%C6%BE&URL=http://cafe.daum.net/reload.html" window.open(url, '', 'toolbar=0,status=0,width=610,height=402,scrollbars=1'); } </xSCRIPT> <BR style="FONT-SIZE: 3px; LINE-HEIGHT: 100%"></TD></TR></TBODY></TABLE> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY></TBODY></TABLE> <TABLE cellSpacing=0 cellPadding=0 width="100%" border=0> <TBODY> <TR> <TD height=8></TD></TR> <TR> <TD class=stext style="PADDING-RIGHT: 14px; PADDING-LEFT: 14px"></TD></TR></TBODY></TABLE> <P style="MARGIN: 15px 0px 0px">출처 : sajudosa님의 인체 해부생리학 통</P>