상처 치유를 촉진하는 병풍추출물(Centella asiatica)에 대한 논문

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상처치유를 촉진하기 위해서 우리는 무엇을 알아야 할까? 

일단 상처치유과정과 치유과정에서 필요한 영양소를 먼저 탐구(클릭클릭)

panic bird..

주름약침과 여드름에 추가할 한약재!!

1472-6882-12-103.pdf

Abstract

Background: The efficacy of Centella asiatica for incision and burn wounds are not fully understood. Here, we

report the wound healing activities of sequential hexane, ethyl acetate, methanol, and water extracts of Centella

asiatica in incision and partial-thickness burn wound models in rats.

Methods: Male Sprague–Dawley rats weighing 250–300 g were randomly divided into incision and burn wound

groups. Each group was stratified into seven subgroups: (1) untreated; (2) NSS-; (3) Tween 20W- (vehicle control); (4)

hexane extract-; (5) ethyl acetate extract-; (6) methanol extract-; and (7) aqueous extract-treated groups. The test

substances were applied topically once daily. The tensile strength of the incision wound was measured on the

seventh day after wound infliction. The general appearance and degree of wound healing of the burn wound were

assessed on Days 3, 7, 10 and 14 after burn injury and prior to histopathological eval‎uation.

Results: On the seventh day after wound infliction, the tensile strength of incision wound in all extract-treated

groups was significantly higher than that of the vehicle control (Tween 20W), but comparable to the NSS-treated

group. The degrees of healing in the burn wound with the four extracts were significantly higher than that of the

control on Days 3, 10 and 14. Histopathological findings on Day 14 after burn injury revealed prominent fibrinoid

necrosis and incomplete epithelialization in the control and untreated groups, whereas fully developed

epithelialization and keratinization were observed in all extract-treated groups. Analysis by thin layer

chromatography demonstrated that the phyto-constituents β-sitosterol, asiatic acid, and asiaticoside and

madecassocide were present in the hexane, ethyl acetate and methanol extracts, respectively.

Conclusions: All extracts of Centella asiatica facilitate the wound healing process in both incision and burn

wounds. Asiatic acid in the ethyl acetate extract seemed to be the most active component for healing the wound.