Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hespe

beyond reason  <div class="figure-file" data-ke-type="file" data-file-src="https://t1.daumcdn.net/cafeattach/z4ZG/6ed8f651260591850ca5d094c1b8d2ffd90263f4?download" data-file-name="Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin.pdf" data-file-size="205054" data-mimetype="application/pdf" data-ke-align="alignCenter"><a href='javascript:fileFilterViewer("https://t1.daumcdn.net/cafeattach/z4ZG/6ed8f651260591850ca5d094c1b8d2ffd90263f4?download", "/cafeattach/z4ZG/6ed8f651260591850ca5d094c1b8d2ffd90263f4", "Antioxidant and Anti&amp;#8208;Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin.pdf", "grpid%3Dz4ZG%26fldid%3DS5zw%26dataid%3D160%26fileid%3D1%26regdt%3D20201108150312&url=https%3A%2F%2Ft1.daumcdn.net%2Fcafeattach%2Fz4ZG%2F6ed8f651260591850ca5d094c1b8d2ffd90263f4")'><div class="image"></div><div class="desc"><div class="filename">Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin.pdf</div><div class="size">200.25KB</div></div></a></div>  ReviewAntioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models  <a href="https://onlinelibrary.wiley.com/action/doSearch?ContribAuthorStored=Parhiz%2C+Hamideh" target="_top" class="ke-link">Hamideh Parhiz</a>  <a href="https://onlinelibrary.wiley.com/action/doSearch?ContribAuthorStored=Roohbakhsh%2C+Ali" target="_top" class="ke-link">Ali Roohbakhsh</a>  <a href="https://onlinelibrary.wiley.com/action/doSearch?ContribAuthorStored=Soltani%2C+Fatemeh" target="_top" class="ke-link">Fatemeh Soltani</a>  <a href="https://onlinelibrary.wiley.com/action/doSearch?ContribAuthorStored=Rezaee%2C+Ramin" target="_top" class="ke-link">Ramin Rezaee</a>  <a href="https://onlinelibrary.wiley.com/action/doSearch?ContribAuthorStored=Iranshahi%2C+Mehrdad" target="_top" class="ke-link">Mehrdad Iranshahi</a>First published: 13 November 2014 <a href="https://doi.org/10.1002/ptr.5256" target="_top" class="ke-link">https://doi.org/10.1002/ptr.5256</a>Citations: <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5256#citedby-section" target="_top" class="ke-link">271</a><a href="https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.5256" target="_top" class="ke-link">Read the full text</a><a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5256#" target="_top" class="ke-link"></a> <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5256#" target="_top" class="ke-link">SHARE</a> AbstractInflammation and oxidative stress are two major causes of various life‐threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have numerous biological properties, particularly antioxidant and anti‐inflammatory. New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well. Various in vitro and in vivo studies have been conducted to eval‎uate Hsd, its metabolites, or its synthetic derivatives at reducing inflammatory targets including NF‐κB, iNOS, and COX‐2, and the markers of chronic inflammation. In this review, new findings regarding the molecular targets of Hsd and Hst in the reduction of oxidative stress are discussed. Also, in the anti‐inflammatory section, we provide a summary of significant investigations concerning the mechanisms of action based on the studied inflammation models. Copyright © 2014 John Wiley & Sons, Ltd.