Re:폐암의 식이요법 White tea & Green tea

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위 게시글 논문의 Discussion..

EGCG, the major constituent of tea catechins, which is found in higher concentrations in white tea then green tea, has been shown to inhibit benxo[a]pyerene-induced mutagenesis in the lung of rpsl transgenic mice (35). Santana-Rios et al reported that white tea exhibited greater antimutagenic activity in the Samonella assay than green tea (16). In additional studies, white tea inhibits 2-Amino-1-Methy-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-induced clonic aberrant crypt foci in male F344 rats by altering the expression‎ of carcinogen-metabolizing enzyme (14). White tea also suppressed intestinal polyp formation to a degree that was equivalent to that obtained with sulindac, a potent nonsteroidal anti-inflammatory drug (36). It is important to point out that the prevailing belief of white tea being more effective than green tea is primarily founded on the higher EGCG content in white tea. As such, this advantage over green tea may be lost when the tea extracts are standardized to contain the same amount of EGCG. However, in our study, we found that standardized WTE containing the same amount of total catechin and EGCG levels as GTE from the same vendor, were actually more potent in inducing apoptosis and augmenting 15-LOX-1, 15-LOX-2 and PPAR-γ mRNA expression‎. What substances in the WTE that may actually be responsible for this phenomenon is unclear. Conceivably, there may be micronutrient or substances that have not yet been characterized and may be a subject of interest for future investigation. Our observations further support the potential advantage of WTE over GTE. This is of particular interests in view of the recent concern over the emerging data showing limited bioavailability of EGCG with green tea studies in vivo (5). Our findings provide important rationales to further investigate the anti-carcinogenic property of WTE and its potential for lung cancer chemoprevention.

White tea의 주성분은 Green tea에도 있는 EGCG!!

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