산삼차 진세노사이드 Rg3의 항피로 효과~?

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진세노사이드 Rg3의 항피로 효과~?


2008년 발표된 논문으로 진세노사이드 Rg3가 항피로에 효과가 있다는 내용입니다..
즉 피로에 사용되는 마커인 SUN, LDH, SOD, MDA, LA이라는 것을 사용하여 살펴보았고, 자체 제품실험에서 홍삼 농축액이나 진액 제품이 이러한 효과가 있는 것으로 비트로시스 연구소에서도 동일한 결과가 나왔다.

The Anti-fatigue Effect of 20(R)-Ginsenoside Rg3 in Mice by Intranasally Administration Wenyan TANG,# Yi ZHANG,# Jing GAO, Xueying DING, and Shen GAO* Department of Pharmaceutics, School of Pharmacy, Second Military Medical University; 325 Guohe Road, Shanghai 20043, P. R. China. Received March 13, 2008; accepted August 2, 2008 20(R)-ginsenoside Rg3 (20(R)-Rg3) has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment.

However, 20(R)-Rg3 has a low bioavailability after oral administration in human due to the first-pass effect.

Recently, nasal route has gained increasing interest as it can avoid first-pass effect for its lower enzymatic activity compared with the gastrointestinal tract and liver. Inorder to provide an animal experimental evidence of 20(R)-Rg3 intranasal administrated preparation, the antifatigue effect of 20(R)-Rg3 after intranasal administration was investigated.

Two weeks after 20(R)-ginsenoside Rg3 was administrated intranasally to mice at three different doses, the anti-fatigue effect of 20(R)-Rg3 was eval‎uated by the weight-loaded swimming test and biochemical parameters related to fatigue, such as serum urea nitrogen (SUN), lactic dehydrogenase (LDH), superoxide dismutase (SOD), malondialdehyde (MDA), blood lactic acid (LA) and hepatic glycogen.

The results showed that compared with the negative control group, the intermediate- dose and the high-dose groups significantly prolonged the weight-loaded swimming time (p0.05; p0.01), and also increased the hepatic glycogen levels (p0.05); SUN levels were decreased considerably in three 20(R)-Rg3-treated groups (p0.01).

In addition, the low-dose group obviously decreased the content of blood LA (p0.05). However, the levels of LDH, SOD and MDA did not show a significant change. Our results predicted a benefit of 20(R)-Rg3 as an anti-fatigue treatment by intranasal administration. The mechanism was related to the increase of the storage of hepatic glycogen, and the decrease of the accumulation of metabolite such as lactic acid and serum urea nitrogen.

Key words 20(R)-ginsenoside Rg3; intranasal administration; anti-fatigue