ER stress문제 해결 보충제 - 이노시톨(레시틴) 기전, 복용법, 용량

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beyond reason

Inositol, phosphatidylinositol and some of their mono- and polyphosphates function as secondary messengers in a number of intracellular signal transduction pathways. They are involved in a number of biological processes, including:

• Insulin signal transduction^[11]
• Cytoskeleton assembly
• Nerve guidance (epsin)
• Intracellular calcium (Ca²⁺) concentration control^[12]
• Cell membrane potential maintenance^[13]
• Breakdown of fats^[14]
• Gene expression‎^[15][16]

이노시톨 - 탄수화물(과일, 콩, 곡물)에 많은 성분

1) 탄수화물 금지식사를 할때

2) ER stress response

3) 우울증, 공황장애, 신경기능이 떨어질때

클릭클릭(유튜브 동영상)

researchers have found that some people with depression, anxiety and compulsive disorders have lower levels of inositol in their brain

이노시톨 복용량

• For mental health conditions: 12–18 grams of MYO once daily for 4–6 weeks (8Trusted Source, 9Trusted Source, 10Trusted Source, 13Trusted Source).
• For polycystic ovary syndrome: 1.2 grams of DCI once daily, or 2 grams of MYO and 200 mcg of folic acid twice daily for 6 months (17Trusted Source, 20Trusted Source).
• For metabolic syndrome: 2 grams of MYO twice daily for one year (23Trusted Source).
• For blood sugar control in gestational diabetes: 2 grams of MYO and 400 mcg of folic acid twice daily during pregnancy (29Trusted Source, 30Trusted Source, 31Trusted Source).
• For blood sugar control in type 2 diabetes: 1 gram of DCI and 400 mcg folic acid once daily for 6 months (34Trusted Source).

Inositol, phosphatidylinositol and some of their mono- and polyphosphates function as secondary messengers in a number of intracellular signal transduction pathways. They are involved in a number of biological processes, including:

• Insulin signal transduction^[11]
• Cytoskeleton assembly
• Nerve guidance (epsin)
• Intracellular calcium (Ca²⁺) concentration control^[12]
• Cell membrane potential maintenance^[13]
• Breakdown of fats^[14]
• Gene expression‎^[15][16]

In one important family of pathways, phosphatidylinositol 4,5-bisphosphate (PIP₂) is stored in cellular membranes until it is released by any of a number of signalling proteins and transformed into various secondary messengers, for example diacylglycerol and inositol triphosphate.^[17]

참고) 레시틴과 이노시톨

근육검사 : 레시틴에는 이노시톨이 함유되어 있으므로 레시틴을 충분히 복용하면 이노시톨 효과를 낼 수 있다 yes

Lecithins are mixtures of glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid.

Inositol: Benefits, Side Effects and Dosage

Inositol, sometimes referred to as vitamin B8, naturally occurs in foods such as fruits, beans, grains and nuts (1Trusted Source). Your body can also produce inositol from the carbohydrates you eat.

However, research suggests that additional inositol in the form of supplements may have numerous health benefits.

This article takes a detailed look at the benefits, recommended dosages and potential side effects of inositol supplements.

What Is Inositol?

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Though often referred to as vitamin B8, inositol is not a vitamin at all but rather a type of sugar with several important functions.

Inositol plays a structural role in your body as a major component of cell membranes (2Trusted Source).

It also influences the action of insulin, a hormone essential for blood sugar control. In addition, it affects chemical messengers in your brain, such as serotonin and dopamine (3Trusted Source, 4Trusted Source).

It has been estimated that a typical diet in the US contains around 1 gram of inositol per day. Rich sources include grains, beans, nuts and fresh fruits and vegetables (1Trusted Source).

However, supplemental doses of inositol are often higher. Researchers have studied the benefits of doses up to 18 grams per day — with promising results and few side effects.

SUMMARYInositol is a type of sugar that helps provide structure to your cells. It also affects the hormone insulin and the function of chemical messengers in your brain.

May Have Mental Health Benefits

Inositol may help balance important chemicals in your brain, including those believed to affect your mood, such as serotonin and dopamine (4Trusted Source).

Interestingly, researchers have found that some people with depression, anxiety and compulsive disorders have lower levels of inositol in their brain (5Trusted Source, 6Trusted Source).

Though more research is needed, several studies suggest that inositol has the potential to be an alternative treatment for mental health conditions. It also seems to have fewer side effects than traditional medications (4Trusted Source).

Panic Disorder

While research is still limited, inositol supplements may be helpful for treating panic disorder, a severe form of anxiety.

Those with panic disorder experience frequent panic attacks, which are sudden feelings of intense fear. Symptoms include rapid heartbeat, shortness of breath, dizziness, sweating and a tingling or numb sensation in the hands (7).

In one study, 20 individuals with panic disorder took either an 18-gram inositol supplement or a common anxiety medication every day for 1 month. Those taking inositol had fewer panic attacks per week, compared to people taking the anxiety medication (8Trusted Source).

Similarly, in a 4-week study, individuals experienced fewer and less severe panic attacks when taking 12 grams of inositol per day (9Trusted Source).

Depression

Inositol may improve symptoms of depression, but research has had mixed results.

For example, an early study demonstrated that taking a 12-gram inositol supplement every day for 4 weeks improved symptoms in people with depression (10Trusted Source).

In contrast, subsequent studies were unable to show any significant benefits (11Trusted Source).

Overall, there is not enough evidence yet to say whether inositol has a true effect on depression.

Bipolar Disorder

As with the other mental health conditions, research on the effects of inositol and bipolar disorder is limited. However, the results of preliminary studies seem promising (12Trusted Source, 13Trusted Source).

For example, a small study in children with bipolar spectrum disorders showed reduced symptoms of mania and depression when a combination of 3 grams of omega-3 fatty acids and up to 2 grams of inositol were taken daily for 12 weeks (12Trusted Source).

In addition, studies suggest that 3–6 grams of inositol taken daily may help reduce symptoms of psoriasis caused by lithium, a common medication used to treat bipolar disorder (14Trusted Source, 15Trusted Source).

SUMMARYThough more research is needed, inositol shows potential as an alternative treatment option for mental health conditions, including panic disorder, depression and bipolar disorder.

카페회원들의 안전을 위해 iframe 태그를 제한 하였습니다. 관련공지보기▶

May Improve Symptoms of Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a condition that causes hormone imbalances in women, which may lead to irregular periods and infertility. Weight gain, high blood sugar and undesirable cholesterol and triglyceride levels are also concerns with PCOS (16).

Inositol supplements may improve PCOS symptoms, particularly when combined with folic acid.

For instance, clinical studies suggest that daily doses of inositol and folic acid may help reduce levels of triglycerides in the blood. They may also improve insulin function and slightly lower blood pressure in those with PCOS (17Trusted Source, 18Trusted Source, 19Trusted Source).

What’s more, preliminary research found that the combination of inositol and folic acid may promote ovulation in women with fertility issues from PCOS (20Trusted Source, 21).

In one study, 4 grams of inositol and 400 mcg of folic acid taken daily for 3 months induced ovulation in 62% of treated women (20Trusted Source).

SUMMARYInositol may help reduce blood triglyceride levels, improve insulin function, lower blood pressure and promote ovulation in women with polycystic ovary syndrome (PCOS).

May Help Control Metabolic Syndrome Risk Factors

Clinical studies suggest inositol supplements may be beneficial for those with metabolic syndrome (21Trusted Source, 22Trusted Source).

Metabolic syndrome is a group of conditions that raise your risk of chronic disease, including heart disease and type 2 diabetes.

Specifically, five conditions are associated with metabolic syndrome (23Trusted Source):

• Excess fat in the stomach area
• High levels of triglycerides in the blood
• Low “good” HDL cholesterol levels
• High blood pressure
• High blood sugar

In a year-long clinical study in 80 women with metabolic syndrome, 2 grams of inositol taken twice daily reduced blood triglyceride levels by an average 34% and total cholesterol by 22%. Improvements in blood pressure and blood sugar were also seen (24Trusted Source).

Amazingly, 20% of the women taking inositol supplements no longer met the criteria for metabolic syndrome by the end of the study (24Trusted Source).

SUMMARYInositol may help control metabolic risk factors by helping lower blood triglyceride levels, blood pressure and blood sugar. It may also improve cholesterol levels.

May Prevent Diabetes During Pregnancy

Some women experience high blood sugar during pregnancy. This condition is called gestational diabetes (GDM) and complicates up to 10% of pregnancies in the US every year (25, 26Trusted Source).

In animal studies, inositol has been directly related to the function of insulin, a hormone that regulates blood sugar levels (27Trusted Source, 28Trusted Source).

Only a limited number of studies are available on the supplement and GDM in humans. However, some suggest that a combination of 4 grams of myo-inositol and 400 mcg of folic acid may be helpful in preventing GDM when taken daily throughout pregnancy (29Trusted Source, 30Trusted Source, 31Trusted Source).

However, more research is needed, as other studies have not shown the same effects (32Trusted Source).

SUMMARYInositol may help prevent high blood sugar levels during pregnancy when taken in combination with folic acid, but more studies are needed to confirm‎ this effect.

Other Potential Benefits

Inositol has been studied as a potential treatment option for many conditions.

Besides those already mentioned, research suggests inositol may be helpful in the following conditions:

• Respiratory distress syndrome: In preterm infants, inositol appears to be helpful for treating breathing issues from underdeveloped lungs (33Trusted Source).
• Type 2 diabetes: A preliminary study suggests that inositol and folic acid taken daily for 6 months may aid blood sugar control in people with type 2 diabetes (34Trusted Source).
• Obsessive-compulsive disorder (OCD): A small study suggests that 18 grams of inositol taken daily for 6 weeks may reduce symptoms of OCD (35Trusted Source).

SUMMARYInositol is a potential treatment option for preterm infants with respiratory distress syndrome. It may also aid blood sugar control in people with type 2 diabetes and may reduce symptoms of obsessive-compulsive disorder.

Side Effects and Interactions

Inositol supplements seem to be well-tolerated by most people.

However, mild side effects have been reported with doses of 12 grams per day or higher. These include nausea, gas, difficulty sleeping, headache, dizziness and tiredness (36Trusted Source).

Up to 4 grams of inositol daily has been taken by pregnant women in studies without adverse effects, though more research is needed in this population (37Trusted Source, 38Trusted Source).

There are also not enough studies to determine the safety of the supplements while breastfeeding. However, breast milk seems to be naturally rich in inositol (39Trusted Source).

In addition, it’s unclear whether inositol supplements are safe for long-term use. In most studies, inositol supplements were only taken for a year or less.

As with any supplement, talk to your doctor before taking inositol.

SUMMARYInositol supplements are associated with very few and only mild adverse effects. More research is needed to determine its safety in pregnant and breastfeeding women as well as in long-term use.

Recommended Dosages

There are two main forms of inositol used in supplements, namely myo-inositol (MYO) and D-chiro-inositol (DCI).

Though there is no official consensus on the most effective type and dosage, the following have appeared to be effective in research studies:

• For mental health conditions: 12–18 grams of MYO once daily for 4–6 weeks (8Trusted Source, 9Trusted Source, 10Trusted Source, 13Trusted Source).
• For polycystic ovary syndrome: 1.2 grams of DCI once daily, or 2 grams of MYO and 200 mcg of folic acid twice daily for 6 months (17Trusted Source, 20Trusted Source).
• For metabolic syndrome: 2 grams of MYO twice daily for one year (23Trusted Source).
• For blood sugar control in gestational diabetes: 2 grams of MYO and 400 mcg of folic acid twice daily during pregnancy (29Trusted Source, 30Trusted Source, 31Trusted Source).
• For blood sugar control in type 2 diabetes: 1 gram of DCI and 400 mcg folic acid once daily for 6 months (34Trusted Source).

While these inositol doses appear to be helpful for certain conditions in the short-term, more research is needed to determine if they’re safe and effective over longer periods.

SUMMARYThere is no official consensus for recommended doses of inositol. Dosage and type of inositol supplement vary depending on the condition.

The Bottom Line

Research suggests that inositol may aid people with mental health and metabolic conditions, such as panic disorder, depression, bipolar disorder, polycystic ovary syndrome, metabolic syndrome and diabetes.

It appears to be safe for most people and cause only mild if any side effects in daily doses up to 18 grams.

While your diet likely contains small amounts of inositol, taking a supplement may prove beneficial for some.

Always discuss the use of supplements with your healthcare provider first.