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Sanofi

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Sanofi S.A.

Type	Société Anonyme
Traded as	Euronext: SAN NYSE: SNY CAC 40 Component
Industry	Pharmaceuticals
Founded	20 August 2004 (by acquisition) as Sanofi Aventis 6 May 2011 as Sanofi
Headquarters	54, Rue La Boétie, 75008 Paris, France
Area served	Worldwide
Key people	Serge Weinberg (Chairman), Olivier Brandicourt (CEO), Jean-François Dehecq (Original Founder)
Products	Prescription and over-the-counter drugs for thrombosis, cardiovascular disease, diabetes, central nervous system disorders, oncology and internal medicine, vaccines (list...)
Revenue	€33.821 billion (2016)[1]
Operating income	€6.534 billion (2016)[1]
Profit	€4.8 billion (2016)[1]
Total assets	€104.672 billion (2016)[1]
Total equity	€57.724 billion (2016)[1]
Number of employees	110,000 (2016)[2]
Subsidiaries	Sanofi Pasteur Genzyme Shantha Biotechnics Chattem Zentiva Medley Nichi-Iko
Website	www.sanofi.com

Sanofi S.A. is a French multinational pharmaceutical company headquartered in Gentilly, France, as of 2013 the world's fifth-largest by prescription sales.^[3] The company was formed as Sanofi-Aventis in 2004 by the merger of Aventis and Sanofi-Synthélabo, which were each the product of several previous mergers. It changed its name to Sanofi in May 2011. The company is a component of the Euro Stoxx 50 stock market index.^[4]

Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical drugs principally in the prescription market, but the firm also develops over-the-counter medication. The company covers seven major therapeutic areas: cardiovascular, central nervous system, diabetes, internal medicine, oncology, thrombosis and vaccines (it is the world's largest producer of the latter through its subsidiary Sanofi Pasteur).^[5]

Contents

  [hide] 

• 1History
  • 1.1Sanofi-Synthélabo
  • 1.2Aventis
    • 1.2.1Sanofi-Aventis merger
• 2Post-merger activities
  • 2.1Acquisition history
• 3Rename to Sanofi and beyond
• 4Products
  • 4.1Prescription medications
    • 4.1.1Autoimmune
    • 4.1.2Cardiovascular
    • 4.1.3Infectious disease
    • 4.1.4Metabolic
    • 4.1.5Neurology
    • 4.1.6Oncology
    • 4.1.7Pain
    • 4.1.8Diabetes
    • 4.1.9Over the counter
  • 4.2Pipeline
  • 4.3Management
  • 4.4Stockholders
• 5Head office
• 6Collaborative research
• 7Sanofi Pasteur
  • 7.1BCG supply shortage 2012-
• 8Associations
• 9Aventis Foundation
• 10See also
• 11Notes
• 12References
• 13External links

History[edit]

Sanofi-Synthélabo[edit]

Sanofi was founded in 1973^[6] as a subsidiary of Elf Aquitaine (a French oil company subsequently acquired by Total), when Elf Aquitaine took control of the Labaz group, a pharmaceutical company. In 1993 Sanofi made a move into the Eastern Europe market by acquiring a controlling interest in Chinoin, a Hungarian drug company that had about US$104 million in sales in 1992.^[7][8] In that same year, Sanofi's made its first significant venture into the U.S., and strengthened its presence in Eastern Europe, by first partnering with Sterling Winthrop and then acquiring the prescription pharmaceuticals business in 1994.^[7][9] Sanofi was incorporated under the laws of France in 1994 as a société anonyme, a form of limited liability company.^[10]:18

Synthélabo was founded in 1970 through the merger of two French pharmaceutical laboratories, Laboratoires Dausse (founded in 1834) and Laboratoires Robert & Carrière (founded in 1899). In 1973, the French cosmetics group L’Oréal acquired the majority of its share capital.^[10]:19 In 1991, Synthelabo acquired Laboratories Delalande^[11] and Laboratoires Delagrange, and through this deal picked up the product metoclopramide.^[12][13]

Sanofi-Synthélabo was formed in 1999 when Sanofi merged with Synthélabo; at the time of the merger Sanofi was the second largest pharmaceutical group in France in terms of sales and Synthélabo was the third largest. The merged company was based in Paris, France.^{[10]:18–19[14]}

The merged companies focused on pharmaceuticals, divesting several businesses soon after the merger, including beauty, diagnostics, animal health and nutrition, custom chemicals, and two medical equipment businesses.^[10]:19

Aventis[edit]

Aventis was formed in 1999 when French company Rhône-Poulenc S.A. merged with the German corporation Hoechst Marion Roussel, which itself was formed from the 1995 merger of Hoechst AG with Cassella, Roussel Uclaf and Marion Merrell Dow. The merged company was based in Schiltigheim, near Strasbourg, France.^{[15]:13[16]:9–11[17]:40–41}

At the time of the merger, Rhône-Poulenc's business included the pharmaceutical businesses Rorer, Centeon (blood products), and Pasteur Merieux (vaccines), the plant and animal health businesses Rhône-Poulenc Agro, Rhône-Poulenc Animal Nutrition, and Merial, and a 67 percent share in Rhodia, a speciality chemicals company.^[16]:10 Hoechst had seven primary businesses: Hoechst Marion Roussel (pharmaceuticals), AgrEvo (a joint venture with Schering in crop protection agents and pest control products), HR Vet (veterinary products), Dade Behring (diagnostics), Centeon, Celanese (chemicals), and Messer (chemicals).^[16]:9 Merieux has been in the business of selling blood products, and In the 1980s during the AIDS epidemic, Merieux and other companies were involved in scandals related to HIV-contaminated haemophilia blood products that were sold to developing nations.^[18]

In mid 2000 Aventis and Millennium Pharmaceuticals, a US biotechnology company formed to discover new drugs based on the then-new science of genomics, announced that Aventis would make a $250M investment in Millennium and would pay $200M to Millennium in research fees over five years, one of the largest such deals between a big pharmaceutical company and a biotech company at the time.^[19]

In late 2000, in the midst of the recall of Starlink, its genetically modified maize product, Aventis announced that it had determined to sell off Aventis Cropscience, the seed and pesticide business unit it had created from the agriculture businesses of its predecessors.^[20] In October 2001, Bayer and Aventis announced that Bayer would acquire the unit for about $6.6 billion, with the unit becoming Bayer CropScience and making Bayer the world's second-largest agrochemical company behind Syngenta.^[21]

In 2003 Aventis entered into a collaboration with Regeneron, a New York biotechnology company, to develop Regeneron's VEGF-inhibiting drug, aflibercept, in the field of cancer, which was then in Phase I clinical trials. Aventis invested $45 million in Regeneron and made an upfront payment of $80 million in cash.^[22] Regeneron partnered the drug with Bayer Healthcare in the field of proliferative eye diseases, and under the name Eylea it was approved by the FDA in 2011;^[23] after several setbacks in clinical trials,^[24] Regeneron and Sanofi got the drug approved in metastatic colorectal cancer in combination with other agents, under the brand name ZALTRAP in 2012.^[25]

Sanofi-Aventis merger[edit]

Sanofi-Aventis was formed in 2004 when Sanofi-Synthélabo acquired Aventis. In early 2004, Sanofi-Synthélabo made a hostile takeover bid worth €47.8 billion for Aventis. Initially, Aventis rejected the bid because it felt that the bid offered inferior value based on the company's share value, and the board of Aventis went so far as to enact poison pill provisions and to invite Novartis to enter merger negotiations.^[26] The three-month takeover battle concluded when Sanofi-Synthélabo launched a friendly bid of €54.5 billion in place of the previously rejected hostile bid. The French government played a strong role, desiring what it called a "local solution", by putting heavy pressure on Sanofi-Synthélabo to raise its bid for Aventis and for Aventis to accept the offer^[27] and by rejecting Aventis' poison pill proposal.^[28] One of the largest risks in the deal for both sides, was the fate of the patents protecting Clopidogrel (Plavix) which was one of the top-selling drugs in the world at the time and the major source of Sanofi's revenue.^[29]

Post-merger activities[edit]

In 2006, Iraqis infected with HIV sued Sanofi and Baxter due to HIV-contaminated haemophilia blood products sold by Merieux in the 1980s.^[30] In 2006 the US patents on clopidogrel (Plavix) were challenged when a Canadian generics company, Apotex, filed an Abbreviated New Drug Application under the Hatch-Waxman Act, received FDA approval, and started marketing a generic clopidogrel. While Sanofi-Aventis and its partner on the drug, Bristol Myers Squibb (BMS), were able to get an injunction to stop Apotex from selling the drug,^[31] the case became complicated when settlement negotiations fell apart twice - the second time due to an oral agreement made by BMS CEO Peter Dolan that BMS failed to disclose to the Federal Trade Commission during the review of the settlement agreement to ensure that it did not violate antitrust law. When Apotex disclosed the oral agreement to the FTC, the FTC launched an investigation that led to Dolan being fired by BMS.^[32] Apotex finally lost on the patent litigation issues after its third appeal was decided in favor of BMS/Sanofi in November 2011; Apotex had to pay ~$442 million in damages and ~$108 million in interest for infringing the patent,^[33] which it paid in full by February 2012.^[34] Apotex also sued BMS and Sanofi for $3.4 billion for allegedly breaching the settlement agreement, and Apotex lost a jury trial in March 2013.^[35]

In 2007 Sanofi-Aventis expanded on Aventis' prior relationship with Regeneron; in the new deal Sanofi-Aventis agreed to pay Regeneron $100 million each year for five years, under which Regeneron would use its monoclonal antibody discovery platform to create new biopharmaceuticals, which Sanofi-Aventis gained the exclusive right to co-develop.^[36] In 2009 the companies expanded the deal to $160 million per year and extended it through 2017.^[36][37] As of 2009 the collaboration had four antibodies in clinical development and had filed an IND for a fifth. Two were against undisclosed targets, one targeted the interleukin-6 receptor as a treatment for rheumatoid arthritis, another targeted nerve growth factor for the treatment of pain, and another targeted delta-like ligand 4 as a treatment of cancer.^[37]

Between 2008, when Chris Viebacher was hired as CEO, and 2010, the company spent more than $17 billion in mergers and acquisitions to strengthen its consumer healthcare and generics platforms especially in emerging markets, in the face of looming patent cliffs and the growth of the consumer healthcare segment.^[38][39][40] In September, for about Zentiva was acquired for €1.8 billion, expanding the groups eastern European markets presence ^[41]

In 2009, Medley Farma, the third largest pharmaceutical company in Brazil and a leading generics company in that country was acquired for about $635 million^[42] Sanofi outbid Teva Pharmaceuticals.^[43] The deal was approved by Brazil's antitrust authorities in May 2010.^[42] Later in the same year Indian vaccine manufacturer Shantha Biotechnics was acquired for $784 million^[44] In October Sanofi-Aventis announced that it would lay off about 1,700 US employees (about 25% of its US workforce) due to restructuring triggered by growing generic competition and other factors, and that the company would focus its US operations on diabetes, atrial fibrillation and oncology.^[45]

In 2010 U.S. consumer healthcare company Chattem, Inc. was acquired for around $1.9 billion.^[40] In the same year, Nepentes Pharma was acquired for $130 million and BMP Sunstone Corporation for $520.6 million.^[46]

In 2011, for around $20.1 billion, Genzyme Corporation, a biotechnology company headquartered in Cambridge, Massachusetts and specialized in the treatment of orphan diseases, renal diseases, endocrinology, oncology and biosurgery.^[47]

In 2014, 66% stake in Globalpharma, Dubai-based generics manufacture.^[48]

In June 2016, the company announced it had struck an asset-swap deal with Boehringer Ingelheim, Sanofi would sell its Merial animal health division (valuing it at €11.4 billion), whilst acquiring Boehringers consumer health division (valuing it at €6.7 billion) and €4.7 billion in cash. The deal means Sanofi is now one of the global consumer healthcare leaders by market share.^[49]

In July 2017, the company announced its intention to acquire Protein Sciences, a privately held, Connecticut-based vaccines biotechnology company, for $650 million and with up to $100 million in milestone achievements.^[50]

Historical financial data (in billions of euro)^{[51][52][53][1]}

Year	2001	2002	2003	2004	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016
Revenue	6.069	7.448	8.048	14.87	27.31	28.37	28.05	27.57	29.31	30.38	33.39	34.95	30.97	31.69	34.54	33,82
Net Income	1.098	1.640	1.865	-3.665	2.202	4.006	5.263	3.851	5.265	5.467	5.646	4.888	3.716	4.390	4.287	4.800
Assets	18.23	17.36	17.42	82.85	86.24	77.76	71.91	71.99	80.25	85.26	100.7	100.4	96.06	97.39	102.3	104.7
Equity	12.75	12.60	12.74	41.63	46.40	45.60	44.54	44.87	48.32	53.10	56.19	57.35	56.9	56.12	58.05	57.72

Note. In 2001—2004 — Sanofi-Synthélabo, in 2004—2011 — Sanofi-Aventis.

Acquisition history[edit]

The following is an illustration of the company's major mergers, acquisitions and historical predecessors:

Sanofi

Sanofi–Aventis

Aventis
(Merged 2004)

Rhône-Poulenc
(Merged 1999)

	Rorer
	Centeon
	Pasteur Merieux
	Rhône-Poulenc Agro
	Rhône-Poulenc Animal Nutrition
	Merial
	Rhodia

Hoechst Marion Roussel

	Hoechst Marion Roussel
	AgrEvo
	HR Vet
	Dade Behring
	Centeon
	Celanese
	Messer

	Aventis Cropscience (Spun off 2000)

Sanofi-Synthélabo
(Merged 1999)

Sanofi

	Sanofi (Founded 1973 as subsidiary of Elf Aquitaine)

Sterling Winthrop
(Acq 1994)

Synthélabo

	Laboratoires Dausse (Founded 1834, merged 1970)
	Robert & Carrière (Founded 1899, merged 1970)

Zentiva
(Acq 2008)

Sicomed SA Bucharest
(Acq 2005)

	Leciva Slovakofarma (Acq 2003)

	Medley Farma (Acq 2009)

	Shantha Biotechnics (Acq 2009)

	Chattem (Acq 2010)

	Nepentes Pharma (Acq 2010)

	BMP Sunstone Corporation (Acq 2010)

Genzyme Corporation (Acq 2011)

Whatman Biochemicals Ltd
(Acq 1981)

Koch-Light Laboratories
(Acq 1982)

Integrated Genetics
(Acq 1989, IPO 1991)

Genecore International
(Diagnostic enzyme div, Acq 1991)

Medix Biotech, Inc.
(Acq 1992)

Enzymatix Ltd
(Acq 1992)

Vivigen
(Acq 1992)

Virotech
(Acq 1993)

Omni Res srl
(Acq 1993)

Sygena Ltd
(Acq 1994)

BioSurface Technology Inc.
(Acq 1994)

TSI Inc.
(Acq 1994)

PharmaGenics, Inc.
(Acq 1997)

Biomatrix
(Acq 2000)

SangStat Medical Corp.
(Acq 2003)

Ilex Oncology Inc.
(Acq 2004)

Bone Care International Inc
(Acq 2005)

AnorMED Inc.
(Acq 2006)

	Bioenvision (Acq 2007)

	Merial (Asset swap with Boehringer Ingelheim for their Consumer Healthcare div, 2016)
	Boehringer Ingelheim (Consumer Healthcare div, 2016)

	Protein Sciences (Acq 2017)

Rename to Sanofi and beyond[edit]

The company dropped the -Aventis suffix of its name on 6 May 2011 after receiving approval at its annual general meeting. The reason given by the company for the change was to make its name easier to pronounce in countries such as China.^[54]

In January 2012, Sanofi co-invested in the $125 million Series A financing of Warp Drive Bio. Sanofi sought support for its internal cancer research program and also took on an obligation to acquire Warp Drive if certain milestones were met.^[55]

In January 2014, Genzyme and Alnylam Pharmaceuticals, a US biotechnology company developing RNAi therapeutics, announced that Genyzme would invest $700 million in Alnylam. Under the deal, Genzyme obtained further rights to patisiran, an RNAi treatment for transthyretin-mediated amyloidosis - a condition that can result in familial amyloidotic polyneuropathy and familial amyloidotic cardiomyopathy,^[56] and obtained rights to other compounds in Alnylam's pipeline.^[57]

In March 2014 Sanofi joined the bidding for Merck & Co.’s over-the-counter health-products unit, the maker of Coppertone sunblock and Claritin allergy medicine; bids were expected to range between $10 billion and $12 billion.^[58]

In October 2014, Sanofi's directors fired US-resident chief executive Chris Viehbacher, blaming his alleged lack of communication with the board and poor execution of his strategy.^[59] Board chairperson Serge Weinberg took over as interim CEO until 2 April 2015 when Bayer Healthcare board chairperson Olivier Brandicourt (appointed by Sanofi on 19 February 2015^[60]) took over. Before Brandicourt even started his new job, French government ministers Stéphane Le Foll and Ségolène Royal attacked the $4.5 million golden handshake he was getting from Sanofi - and his pay of about $4.7 million a year.^[61]

In July 2015, Genzyme announced it would acquire the rare cancer drug Caprelsa (vandetanib) from AstraZeneca for up to $300 million.^[62] In the same month In July 2015, the company announced a new global collaboration with Regeneron to discover, develop, and commercialise new immuno-oncology drugs, which could generate more than $2 billion for Regeneron,^[63] with $640 million upfront, $750 million for proof of concept data and $650 million from the development of REGN2810.^[64]

Products[edit]

Prescription medications[edit]

Autoimmune[edit]

• Epinephrine autoinjector (Auvi-Q in the US and Allerject in Canada), licensed from Intelliject^[65] and approved by the FDA in 2012 for emergency treatment of life-threatening allergic reactions.^[66]
• Teriflunomide (Aubagio), small molecule for multiple sclerosis. Approved by the FDA in September 2012.^[67]

Product Recall and Effects: The Epinephrine auto-injection devices made by Sanofi SA currently on the market in the U.S. and Canada were voluntarily recalled on October 28, 2015.^[68][69] The reason stated by Sanofi was that the products have been found to potentially have inaccurate dosage delivery, which may include failure to deliver drug.^[70][71]

Sanofi US also added the following warning: If a patient experiencing a serious allergic reaction (i.e., anaphylaxis) did not receive the intended dose, there could be significant health consequences, including death because anaphylaxis is a potentially life‑threatening condition.^[70]

In its news Release on October 28, 2015, Sanofi Canada stated that it was "actively working with suppliers of alternative epinephrine auto-injectors to have a full stock available in Canada as soon as possible. Canadian customers were asked to immediately return the Allerject product to their local pharmacy to obtain an alternate epinephrine auto-injector."^[72]

The U.S. Food and Drug Administration also filed a news release^[71] confirm‎ing that the recall involves all Auvi-Q currently on the market in the U.S. The FDA release went on to provide information for consumers re: exchanging the device for another brand of product, also provided on the Auivi-Q web site. Sanofi US will provide reimbursement for out of pocket costs incurred for the purchase of new, alternate epinephrine auto-injectors with proof of purchase.

The alternate products expected to most commonly replace the recalled Sanofi devices are the EpiPens made by Mylan in the US and by Pfizer—under license from Mylan—in Canada.^[73] Mylan already had an 85% market share of the auto-injectors in the US^[74] in the first half of 2015. Maylan is expected to benefit from the recall by its competitor Sanofi, according to a report published in the Fierce Pharma newsletter of November 2, 2015: ".... it is very hard to see Auvi-Q returning to the market, as it will need to be redesigned and face uphill battle to recapture patient trust after the recall," Bernstein analyst Ronny Gal wrote in a note to clients on Monday.^[75] Gal also believes that the company will eventually have 95% of the Epinephrine auto-injector market, according to another Fierce Pharma report on November 3, 2015.^[76]

Cardiovascular[edit]

• Clopidogrel (Plavix, Iscover) for atherothrombosis
• Enoxaparin (Lovenox, Clexane) for thrombosis (its biggest seller in 2008)^[77]
• Mipomersen (Kynamro), an antisense drug invented by Isis Pharmaceuticals and acquired by Genzyme in 2008 (pre-Sanofi)^[78] and approved by the FDA in 2013 for the orphan disease homozygous familial hypercholesterolemia.^[79]
• Irbesartan (Aprovel, Avapro, Karvea) and Ramipril (Delix, Triatec, Tritace) for hypertension
• Alirocumab (Praluent) for heterozygous familial hypercholesterolemia and clinical atherosclerotic cardiovascular disease
• dupilumab (Dupixent) for heart disease

Infectious disease[edit]

• Antibiotics:
  • Cefotaxime (Claforan)
  • Rifapentine (Priftin)
  • Levofloxacin (Tavanic)
  • Amoxicillin/clavulanic acid (Amoklavin)
• Vaccines:
  • Bacterial diseases:
    • Cholera
    • Diphtheria
    • Haemophilus influenzae type b
    • Meningococcal infections (Menactra)
    • Pertussis
    • Pneumococcal infections
    • Tetanus
    • Tuberculosis
    • Typhoid Fever
  • Viral diseases:
    • Hepatitis A
    • Hepatitis B
    • Influenza
    • Japanese Encephalitis (Ixiaro)
    • Measles
    • Mumps
    • Poliomyelitis
    • Rabies
    • Rubella
    • Varicella
    • Yellow Fever
    • Smallpox - eradicated in 1980 (vaccine produced as a measure in response to the threat of bioterrorism)

Metabolic[edit]

• Glimepiride (Amaryl) for type 2 diabetes mellitus
• Human Insulin (Insuman) for type 1 and type 2 diabetes mellitus
• Insulin glulisine (Apidra) and Insulin glargine (Lantus) for diabetes
• Risedronic acid (Actonel) for osteoporosis and Paget’s disease
• Sevelamer hydrochloride (Renagel and Renvela) for end stage renal disease
• carmustine implants (Gliadel) for cancer

Neurology[edit]

• Sodium hyaluronate (Hyalgan) for Blood Tests
• Valproic acid (Depakine) and Valproate semisodium (Depakote) for epilepsy
• Zolpidem (Ambien, Ambien CR, Myslee, Stilnoct, Stilnox, Zolfresh, Zolt) for insomnia

Oncology[edit]

• Alfuzosin (Xatral/Uroxatral) for benign prostatic hyperplasia
• Cabazitaxel (Jevtana) for prostate cancer
• Plerixafor (Mozobil) macrocycle approved by the FDA for peripheral blood stem cell mobilizer for non-Hodgkins lymphoma and multiple myeloma in December 2008.^[80]
• Aflibercept (ZALTRAP) recombinant fusion protein, approved in metastatic colorectal cancer in combination with other agents in 2012.^[25]
• Clomifene (Clomid) for Female infertility
• Docetaxel (Taxotere) for breast, lung and prostate cancer
• Oxaliplatin (Eloxatin) for colorectal cancer
• Sarilumab (Kevzara) for Blood Tests, lung and prostate cancer
• vandetanib (Caprelsa) for breast, colorectal cancer and Female infertility

Pain[edit]

• Codeine (Solpadol) for Chronic pain
• Ketoprofen (Bi-profined) for pain

Diabetes[edit]

• Toujeo (insulin glargine) for type 1 and type 2 diabetes mellitus
• Lantus (insulin glargine) for type 1 and type 2 diabetes mellitus

Over the counter[edit]

• Fexofenadine (Allegra, Telfast) and Triamcinolone (Nasacort) for allergic rhinitis
• Paracetamol (Novaldol)
• Calcium carbonate (Maalox, an antacid)

The company also produces a broad range of over-the-counter products, among them Allegra, IcyHot for muscle pain, Gold Bond for skin irritation, and Selsun Blue dandruff shampoo (these brands were acquired in 2010 when Sanofi-Aventis purchased Chattem).

Pipeline[edit]

As of the summer of 2013, Sanofi was in a race with Amgen and Pfizer to win approval for a drug that inhibits PCSK9, a protein that slows the clearance of low-density lipoprotein (LDL) cholesterol - the form of cholesterol that leads to heart attacks.^[81] Sanofi's drug was discovered by Regeneron and is called alirocumab.^[82] An FDA warning in March 2014 about possible cognitive adverse effects of PCSK9 inhibition threw the competition into disarray, as the FDA asked companies to include neurocognitive testing into their Phase III clinical trials.^[83]

In fall 2013 Sanofi announced that another candidate from its collaboration with Regeneron, the monoclonal antibody against the interleukin 6 receptor, sarilumab, had better efficacy than placebo in its first Phase III trial for rheumatoid arthritis.^[84]

Management[edit]

• Olivier Brandicourt, Chairman, Chief executive officer^[85]
• Jean-François Dehecq was the General Manager of Sanofi from its creation in 1973 until 2007.

Stockholders[edit]

As of 31 December 2013:^[86]:185

• Breakdown of share ownership: 8.93% by L'Oréal, 0.27% treasury shares and 1.31% employees. The remaining 89.49% were publicly traded.^[A]

Head office[edit]

Head office 54 rue de la Boétie, Paris 8th around.

Former head office 174 avenue de France, Paris 13th around.

In January 2012, Sanofi moved its head office location to 54, Rue La Boétie in the 8th arrondissement of Paris. This former mansion designed by architect René-Patouillard had previously been the head office of Alcatel-Lucent.

Sanofi's previous head office was located in the 13th arrondissement of Paris, 174 Avenue de France. The architecture of the head office is of the predominant style of the area surrounding the François Mitterrand Library. After Sanofi and Aventis merged, the employees at the former Aventis head office in Schiltigheim, Alsace moved to Paris.^[88] In June 2015, the headquarters were moved to Gentilly, just south of Paris.

Collaborative research[edit]

In addition to internal research and development activities Sanofi is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical safety assessment is the InnoMed PredTox project^[89][90] The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.^[91]

In June 2010, Sanofi and the Charite University of Berlin signed a cooperation agreement for the research and development of medicines and therapies.^[92]

On 25 October 2012, Sanofi said its earnings for the third quarter slumped as generic competitors ate into profits of its Eloxatin cancer treatment.^[93]

Sanofi Pasteur[edit]

Main article: Sanofi Pasteur

In 2005 Sanofi Pasteur, vaccines division of Sanofi Group, was awarded a $97 Million HHS contract in 2005.^[94]

BCG supply shortage 2012-[edit]

In the fall of 2011 the Sanofi Pasteur plant flooded causing problems with mold.^[95] The facility, located in Toronto, Ontario, Canada, produced BCG vaccine products, made with the Glaxo 1077 strain,^[96] such as a tuberculosis vaccine ImmuCYST, a BCG Immunotherapeutic -a bladder cancer drug. By April 2012 the FDA had found dozens of documented problems with sterility at the plant including mold, nesting birds and rusted electrical conduits.^[95] The resulting closure of the plant for over two years resulting in shortages of bladder cancer and tuberculosis vaccines.^[97] The Toronto Sanofi plant^[98] On October 29, 2014 Health Canada gave the permission for Sanofi to resume production of BCG.^[99]

Associations[edit]

Sanofi is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA),^[100] Biotechnology Industry Organization (BIO),^[101] and Pharmaceutical Research and Manufacturers of America (PhRMA).^[102]

Sanofi's vaccine subsidiary, Sanofi Pasteur, is a member of EuropaBio.^[103]

Aventis Foundation[edit]

The Aventis Foundation,^[104] a German charitable trust, was established in 1996 as the Hoechst Foundation with an endowment of €50 million. In 2000, the foundation was renamed the Aventis Foundation. Its aim is to promote music, theater, art, literature, higher education and healthcare research.^{[citation needed]}

See also[edit]

• Aventis Pharma
• Sanofi Biogenius Canada

• Paris portal
 
• Companies portal

Notes[edit]

1. Jump up^ Total reduced its stake to less than 5% in 2011.^[87]

References[edit]

1. ^ Jump up to:^{a b c d e f} "Annual Report 2016". Sanofi S.A. 2017-02-08. Retrieved 2017-02-25.
2. Jump up^ "Sanofi 2016 Factsheet" (PDF). Sanofi S.A. Retrieved 25 February 2017.
3. Jump up^ Eric Palmer and Carly Helfand for FiercePharma. 4 March 2014 The top 10 pharma companies by 2013 revenue
4. Jump up^ "Börse Frankfurt (Frankfurt Stock Exchange): Stock market quotes, charts and news". www.boerse-frankfurt.de. Retrieved 23 May 2017.
5. Jump up^ "Sanofi-Aventis to sign deal to build flu vaccine plant in China - source". AFX News. Forbes. 23 November 2007. Retrieved 2009-04-19.
6. Jump up^ "Le fondateur de Sanofi est mort". lexpress.fr. Retrieved 4 June 2015.
7. ^ Jump up to:^a b Staff, The Pharma Letter. Sept 20, 1993 Sanofi Extends Holding in Chinoin
8. Jump up^ Chinoin listing in at securities.com Page accessed Feb 5, 2016
9. Jump up^ Collins, Joseph C.; Gwilt, John R. (2000). "The Life Cycle of Sterling Drug, Inc" (PDF). Bull. Hist. Chem. 25 (1): 22–27.
10. ^ Jump up to:^a b c d Sanofi-Synthélabo Form 20F for the Fiscal Year ended 31 December 2002
11. Jump up^ Denis Cosnard for Les Echos. December 11, 1991. Synthélabo s'offre Delalande
12. Jump up^ Denis Conard for Les Echos. Oct 17, 1991 Synthélabo rachète les laboratoires Delagrange
13. Jump up^ Bibliothèque nationale de France Laboratoires Delagrange Page accessed Aug 24, 2016
14. Jump up^ Tom Meek for PMLiVE May 24, 2013 A look back at Sanofi's merger with Synthélabo
15. Jump up^ Aventis Form 20-F for the fiscal year ended 31 December 2002
16. ^ Jump up to:^a b c Arturo Bris and Christos Cabolis, Corporate Governance Convergence Through Cross-Border Mergers The Case of Aventis, Chapter 4 in Corporate Governance and Regulatory Impact on Mergers and Acquisitions: Research and Analysis on Activity Worldwide Since 1990. Eds Greg N. Gregoriou, Luc Renneboog. Academic Press, 26 July 2007
17. Jump up^ Lawton Robert Burns The Business of Healthcare Innovation Cambridge University Press, 26 July 2012
18. Jump up^ Meier, Barry (1996-06-11). "Blood, Money and AIDS: Haemophiliacs Are Split; Liability Cases Bogged Down in Disputes". The New York Times.
19. Jump up^ Andrew Pollack for the New York Times. 24 June 2000 Aventis Unit Sets Big Investment in Biotechnology Start-Up
20. Jump up^ New York Times, 16 November 2000 Aventis to Sell Agriculture Unit
21. Jump up^ CNN Money. 2 October 2001 Bayer buys CropScience
22. Jump up^ Candace Hoffmann for First Word Pharma. 8 September 2003 Aventis inks deal with Regeneron for collaboration on cancer therapy
23. Jump up^ Gever, John (19 November 2011). "FDA Approves Eylea for Macular Degeneration". MedpageToday.com. Retrieved 2013-10-16.
24. Jump up^ Ciombor KK et al. Aflibercept Clin Cancer Res. 15 Apr 2013; 19(8): 1920–1925. PMID 23444216
25. ^ Jump up to:^a b "Ziv-Aflibercept". FDA Drug Approvals Database. Food and Drug Administration. 3 August 2012. Retrieved 2013-10-16.
26. Jump up^ Heather Timmons for the New York Times. 3 April 2004 Aventis Invites Novartis To Counter Sanofi's Bid
27. Jump up^ Heather Timmons for the New York Times. 27 April 2004 France Helped Broker the Aventis-Sanofi Deal
28. Jump up^ New York Times 24 April 2004 Aventis Plan Is Rejected
29. Jump up^ Kimberly S Cleaves and Ann M Thayer Warning, merge with care: Sanofi-AventisModern Drug Discovery, August 2004:21-26
30. Jump up^ Paul von Zielbauer for the New York Times. 4 September 2006 Iraqis Infected by H.I.V.-Tainted Blood Try New Tool: A Lawsuit
31. Jump up^ BMS Press Release. 8 December 2006 Preliminary Injunction Against Apotex Upheld on Appeal
32. Jump up^ Aaron Smith for CNNMoney.com 26 October 2006 Bristol CEO Dolan gets fired: Company says it heeded request of a federal monitor
33. Jump up^ Donald Zuhn for Patent Docs. 9 November 2011 Sanofi-Aventis v. Apotex Inc. (Fed. Cir. 2011)
34. Jump up^ Linda a. Johnson for Associated Press 8 February 2012 Apotex pays Bristol, Sanofi damages over Plavix
35. Jump up^ Carolina Bolado for Law360 14 March 2013. Bristol-Myers Escapes $3.4B Apotex Suit Over Plavix Deal
36. ^ Jump up to:^a b Ron Winslow for the Wall Street Journal. 10 Nov. 2009 Sanofi Expands Regeneron Deal
37. ^ Jump up to:^a b Genetic Engineering and Biotechnology News. 11 Nov 2009 Sanofi-Aventis Commits Over $2.8B to Regeneron in mAb Discovery Alliance
38. Jump up^ FierceBiotech. Sanofi-Aventis: A timeline of biopharma deals
39. Jump up^ Andy Tisman for IMS Health 2010 The Rising Tide of OTC in Europe
40. ^ Jump up to:^a b Reuters, 21 December 2009 Drug Maker Sanofi-Aventis Buys Chattem for $1.9 Billion
41. Jump up^ New York Times. 22 September 2008 Sanofi-Aventis to buy Czech generic drug maker
42. ^ Jump up to:^a b Leigh Kamping-Carder for Law360. 20 May 2010 Brazil Clears Sanofi's $635M Medley Pharma Buy
43. Jump up^ Gareth Macdonald for PharmaTechnologist, 15 April 2009 Sanofi beats Teva in Medley melee
44. Jump up^ "Sanofi snaps up India's Shantha for $784M". FierceBiotech.
45. Jump up^ Thomas Gryta and Mimosa Specer for the Wall Street Journal. Updated 9 Oct. 2010 Sanofi Cuts Jobs, Counters Genzyme
46. Jump up^ Phil Serafino for Bloomberg News. 28 October 2010 Sanofi-Aventis to Buy BMP Sunstone to Expand in China
47. Jump up^ Chris V. Nicholson for the New York Times' Dealbook. 16 February 2011 Sanofi Agrees to Buy Genzyme for $20.1 Billion
48. Jump up^ Eric Palmer (2014-06-26). "Sanofi buys Dubai's Globalpharma to produce generics in the Middle East". Questex LLC. Retrieved 2017-02-24.
49. Jump up^ "Aiming for top dog status, Sanofi and Boehringer swap animal and consumer health units - FiercePharma".
50. Jump up^ http://mediaroom.sanofi.com/sanofi-to-acquire-protein-sciences/
51. Jump up^ "Annual Report 2005 on SEC Filing Form 20-F". Sanofi. 2006-03-31. Retrieved 2017-02-22.
52. Jump up^ "Annual Report 2010 on SEC Filing Form 20-F". Sanofi. 2011-03-01. Retrieved 2017-02-22.
53. Jump up^ "Annual Report 2015 on SEC Filing Form 20-F". Sanofi. 2016-03-04. Retrieved 2017-02-22.
54. Jump up^ Mennella, Noelle (6 May 2011). "Sanofi changes name, pace of acquisitions to slow". Reuters. Retrieved 7 May 2011.
55. Jump up^ Arlene Weintraub for Xconomy. 10 January 2012 Warp Drive Bio Launches With $125M from Third Rock, Greylock, Sanofi
56. Jump up^ Alnylam, TTR Amyloidosis (FAP)
57. Jump up^ Chad Bray for the New York Times' Dealbook. 13 January 2014 Sanofi Unit to Buy $700 Million Stake in Rare Disease Company
58. Jump up^ Bloomberg News [1] 24 March 2014
59. Jump up^ French drugmaker Sanofi sacks CEO, shares drop, Natalie Huet and Noëlle Mennella, Reuters news agency, New York 29 October 2014.Retrieved: 6 July 2015.
60. Jump up^ Sanofi : Sanofi Appoints Olivier Brandicourt as Chief Executive Officer, Sanofi corporate website, 19 February 2015.Retrieved: 6 July 2015.
61. Jump up^ French Government Slams Sanofi Over Brandicourt Pay Package, The Wall Street Journal, 24 February 2015].Retrieved: 6 July 2015.
62. Jump up^ "Genzyme to Buy Caprelsa from AstraZeneca for Up to $300M - GEN News Highlights - GEN".
63. Jump up^ "Regeneron, Sanofi Launch $2B+ Immuno-Oncology Collaboration - GEN News Highlights - GEN".
64. Jump up^ "UPDATED: Struggling Sanofi paying $1.8B to partner with Regeneron on immuno-oncology - FierceBiotech".
65. Jump up^ http://www.kaleopharma.com/intelliject-inc-receives-fda-approval-for-auvi-qtm-epinephrine-injection-usp/
66. Jump up^ Katie Thomas for the New York Times. 1 February 2013 Brothers Develop New Device to Halt Allergy Attacks
67. Jump up^ "FDA approves new multiple sclerosis treatment Aubagio" (Press release). US FDA. Retrieved 2012-09-14.
68. Jump up^ "All Allerject epinephrine auto-injectors recalled".
69. Jump up^ http://www.allerject.ca/Common/docs/en/Sanofi-Canada-Issues-Voluntary-Recall-of-Allerject.pdf
70. ^ Jump up to:^a b "Auvi-Q® (epinephrine injection, USP)".
71. ^ Jump up to:^a b Commissioner, Office of Regulatory Affairs, Office of the. "Recalls, Market Withdrawals, & Safety Alerts - UPDATED: Sanofi US Issues Voluntary Nationwide Recall of All Auvi-Q® Due to Potential Inaccurate Dosage Delivery". www.fda.gov. Retrieved 23 May 2017.
72. Jump up^ "Sanofi Canada Issues Voluntary Nationwide Recall of Allerject® Due to Potential Inaccurate Dosage".
73. Jump up^ "Welcome to EpiPen® 101".
74. Jump up^ Reprints, Cynthia Koons CynthiaLKoons Robert Langreth RobertLangreth. "How Marketing Turned the EpiPen Into a Billion-Dollar Business".
75. Jump up^ "Sanofi's Auvi-Q recall puts Mylan's rival EpiPen in full control of blockbuster market - FiercePharma".
76. Jump up^ "It's open season for Mylan's EpiPen as Sanofi, Teva stumble - FiercePharma".
77. Jump up^ "Annual Review 2008" (PDF). Sanofi-Aventis. Retrieved 2009-04-19.
78. Jump up^ Lisa M. Jarvis for Chemical and Engineering News. 14 January 2008 Isis, Genzyme In Heart Drug Deal
79. Jump up^ Andrew Pollack for the New York Times. 29 January 2013 F.D.A. Approves Genetic Drug to Treat Rare Disease
80. Jump up^ "Mozobil approved for non-Hodgkin's lymphoma and multiple myeloma" (Press release). Monthly Prescribing Reference. 18 December 2008. Retrieved 3 January 2009.
81. Jump up^ Gina Kolata for the New York Times. 9 July 2013 Rare Mutation Ignites Race for Cholesterol Drug
82. Jump up^ Alirocumab on Regeneron's website Archived 16 April 2012 at the Wayback Machine.
83. Jump up^ John Carroll for FierceBiotech 7 March 2014 UPDATED: Regeneron, Sanofi and Amgen shares suffer on FDA's frets about PCSK9 class
84. Jump up^ John Carroll for FierceBiotech 22 November 2013 Regeneron, Sanofi hit a trio of goals in first PhIII test of rheumatoid arthritis drug
85. Jump up^ Noemie Bisserbe for the Wall Street Journal. 20 Feb. 2015 Sanofi Names Olivier Brandicourt CEO
86. Jump up^ "Annual Report 2013" (PDF). Sanofi-Aventis. Retrieved 13 April 2014.
87. Jump up^ MarketWatch 29 April 2011 Total CFO says firm cut Sanofi stake to under 5%
88. Jump up^ "Sanofi-Aventis : regroupement à Paris." Le Journal du Net. Retrieved on 28 September 2010.
89. Jump up^ Mattes, William B. (2008). "Public Consortium Efforts in Toxicogenomics". In Mendrick, Donna L.; Mattes, William B. Essential Concepts in Toxicogenomics. Methods in Molecular Biology. 460. pp. 221–238. doi:10.1007/978-1-60327-048-9_11. ISBN 978-1-58829-638-2. PMID 18449490.
90. Jump up^ "InnoMed PredTox Member Organizations". Archived from the original on 26 September 2008. Retrieved 2008-08-25.
91. Jump up^ Innovative Medicines Initiative. "IMI Call Topics 2008". IMI-GB-018v2-24042008-CallTopics.pdf. European Commission. Retrieved 2008-08-25.^{[dead link]}
92. Jump up^ Sanofi-aventis, Charite University Sign Cooperation Agreement News article from InfoGrok.
93. Jump up^ "Sanofi Earns Slump in Q3 as Competition Heats Up". The New York Times. 25 October 2012.
94. Jump up^ "Sanofi pasteur Awarded $97 Million HHS Contract to Accelerate Cell-Culture Pandemic Influenza Vaccine Development". 4 January 2005. Retrieved 12 June 2013.
95. ^ Jump up to:^a b "April 2012 Inspectional Observations (form 483)", U.S. Food and Drug Administration, Vaccines, Blood & Biologics, 12 April 2012, retrieved 29 January 2016
96. Jump up^ Fine, P.E.M (2004). Issues relating to the use of BCG in immunization programmes: A discussion document, WHO/V&B/99.23 (PDF). Geneva: WHO.
97. Jump up^ Palmer, Eric (10 September 2014), "Merck again shipping BCG cancer treatment but Sanofi still is not: Shortages of bladder cancer and tuberculosis treatment have persisted for two years", FiercePharma
98. Jump up^ Palmer, Eric (12 July 2012), "Merck again shipping BCG cancer treatment but Sanofi still is not: Shortages of bladder cancer and tuberculosis treatment have persisted for two years", FiercePharma
99. Jump up^ Palmer, Eric (31 March 2015), "Sanofi Canada vax plant again producing ImmuCyst bladder cancer drug", FiercePharma, retrieved 29 January 2016
100. Jump up^ "The Pharmaceutical Industry in Figures - 2008 Edition". European Federation of Pharmaceutical Industries and Associations (EFPIA). p. 49. Archived from the originalon 16 September 2008. Retrieved 25 August 2008.
101. Jump up^ BIO member list Accessed 19 April 2014
102. Jump up^ PhRMA member list Accessed 19 April 2014
103. Jump up^ EuropaBio member list Accessed 19 April 2014
104. Jump up^ Home. Aventis Foundation (2013-11-27). Retrieved on 2013-12-23.

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