<p><span role="menubar"><a title="Cancer research." role="menuitem" aria-expanded="false" aria-haspopup="true" href="http://www.ncbi.nlm.nih.gov/pubmed/?term=diet+mammart+gland++part+12-lipoxygenass+pathway#" abstractlink="yes" alsec="jour" alterm="Cancer Res."><font color="#0066cc">Cancer Res</font></a></span> 2016 Jan 1;76(1):24-9. doi: 10.1158/0008-5472.CAN-14-3432.</p><p><br></p><p><strong>A Sucrose-Enriched <span class="highlight">Diet</span> Promotes Tumorigenesis in <span class="highlight">Mammary Gland</span> in <span class="highlight">Part</span> through <br>the 12-Lipoxygenase <span class="highlight">Pathway</span></strong>.</p><p><br></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Jiang%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Jiang Y</font></a><sup><font size="2">1</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Pan%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Pan Y</font></a><sup><font size="2">1</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Rhea%20PR%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Rhea PR</font></a><sup><font size="2">1</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Tan%20L%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Tan L</font></a><sup><font size="2">1</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Gagea%20M%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Gagea M</font></a><sup><font size="2">2</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Cohen%20L%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Cohen L</font></a><sup><font size="2">1</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Fischer%20SM%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Fischer SM</font></a><sup><font size="2">3</font></sup>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20P%5BAuthor%5D&cauthor=true&cauthor_uid=26729790"><font color="#0066cc">Yang P</font></a><sup><font size="2">4</font></sup>.</p><p><br></p><div class="abstr"><h3>Abstract</h3><div><p><abstracttext>Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. <br>One proposed mechanism for how sugar impacts cancer development involves inflammation. <br>In the current study, we investigated the impact of dietary sugar on <span class="highlight">mammary gland</span> tumor development in multiple <br>mouse models, along with mechanisms that may be involved. <br>We found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and <br>metastasis, when compared with a nonsugar starch <span class="highlight">diet</span>. <br>This effect was ascribed in <span class="highlight">part</span> to increased expression‎ of 12-lipoxygenase (12-LOX) and its arachidonate metabolite <br>12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE). <br>We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE <br>production in breast tumors. <br>Overall, our data suggested that dietary sugar induces 12-LOX signaling to increase risks of breast cancer development <br>and metastasis.</abstracttext></p></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMID: 26729790</dt><dt><br></dt><dt><br></dt><dt><strong>Cancer Research</strong>는 본원 구독 전자저널은 아닙니다.</dt><dt>원내에서 PDF가 바로 열리지는 않지만, <strong><span style="color: rgb(9, 0, 255);">당일 인쇄형태로 무료 제공 가능</span></strong>합니다.</dt></dl></div><p><br></p><p>당일 인쇄형태 무료 제공 가능한 저널 목록 확인 <br>☞ <a href="http://www.fric.kr/user/centerMainView.do?centerId=total">http://www.fric.kr/user/centerMainView.do?centerId=total</a></p><p><br></p><p>본 원 이용자에게는 무료로 제공이 가능하나 다른 기관들의 경우 기관에 따라 요금이 차등 부과될 수 있습니다.</p><p><br></p><p>또한 제공 목록에 있는 저널이라도 논문에 따라 제공이 불가능할 수도 있습니다.<br></p></div><p><br></p>
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