Re: 글루타치온의 치매치료 효과

[문형철]

Review

J Alzheimers Dis

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. 2019;68(2):531-535.

 doi: 10.3233/JAD-181054.

Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward

Pravat K Mandal 1 2, Deepika Shukla 1, Manjari Tripathi 3, Lars Ersland 4 5 6

Affiliations expand

• PMID: 30776003
• DOI: 10.3233/JAD-181054

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be important player in AD pathology. Glutathione (GSH) is a major antioxidant, and it is already known that GSH is depleted significantly in the hippocampal regions in mild cognitive impairment (MCI) and AD patients compared to healthy old subjects. Hence there is a serious discussion to improve the brain GSH level by supplementation. This editorial highlights the need for GSH supplementation for the cognitive enhancement in MCI and AD.

알츠하이머병(AD)은 전 세계 수백만 명의 사람들에게 영향을 미치는 치명적인 신경 퇴행성 질환입니다. 알츠하이머병의 실제 원인은 아직 밝혀지지 않았습니다. 산화 스트레스는 알츠하이머병 병리에서 중요한 역할을 하는 것으로 알려져 있습니다. 글루타치온(GSH)은 주요 항산화 물질로, 건강한 노인에 비해 경도인지장애(MCI) 및 알츠하이머병 환자의 해마 부위에서 GSH가 현저히 고갈되어 있는 것으로 이미 알려져 있습니다. 따라서 보충제를 통해 뇌 GSH 수치를 개선하기 위한 논의가 활발히 진행되고 있습니다. 이 사설은 경도인지장애와 알츠하이머병의 인지력 향상을 위해 GSH 보충제의 필요성을 강조합니다.

Review

J Alzheimers Dis

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. 2014;40(3):519-29.

 doi: 10.3233/JAD-132483.

The emerging role of glutathione in Alzheimer's disease

Sumiti Saharan 1, Pravat K Mandal 2

Affiliations expand

• PMID: 24496077
• DOI: 10.3233/JAD-132483

Abstract

With millions of older individuals presently suffering from Alzheimer's disease (AD) worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected individuals and their families. One of the emerging causative factors associated with AD pathology is oxidative stress. This AD-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (GSH). In this article, we review the role of GSH in AD from a pathological as well as a diagnostic point of view. We recapitulate the literature that has assessed the role of GSH in AD onset and progression. We discuss the various methodologies through which alterations in GSH levels might be monitored, and highlight the yet uncharted potential of assaying GSH levels in vivo with magnetic resonance spectroscopy in AD therapeutics and prognostics. Finally, the present manuscript integrates findings from various studies to elucidate the possible molecular mechanisms through which disruptions in GSH homeostasis may contribute to AD pathology.

현재 전 세계적으로 수백만 명의 노인이 알츠하이머병(AD)을 앓고 있는 가운데, 알츠하이머병은 지나치게 흔한 형태의 치매로 환자와 그 가족에게 막대한 피해를 입히고 있습니다. AD 병리와 관련된 새로운 원인 요인 중 하나는 산화 스트레스입니다. 알츠하이머병과 관련된 산화 스트레스의 증가는 뇌 항산화제인 글루타치온(GSH)의 수치 감소에 기인합니다. 이 글에서는 알츠하이머병에서 GSH의 역할을 병리학적 관점과 진단적 관점에서 검토합니다. 알츠하이머병 발병과 진행에서 GSH의 역할을 평가한 문헌을 요약합니다. 또한 GSH 수치의 변화를 모니터링할 수 있는 다양한 방법론에 대해 논의하고, AD 치료 및 예후 예측에서 자기공명분광법으로 생체 내 GSH 수치를 분석할 수 있는 아직 알려지지 않은 잠재력에 대해 강조합니다. 마지막으로, 본 논문은 다양한 연구 결과를 통합하여 GSH 항상성 장애가 AD 병리에 기여할 수 있는 가능한 분자 메커니즘을 설명합니다.