Publications

[tbkang]

2021

Down-regulation of pro-necroptotic molecules blunts necroptosis during myogenesis.

Biochemical and Biophysical Research Communications 557 (2021) 33-39.

Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation.

Int J Mol Sci. 2021 Mar 24;22(7):3318. doi: 10.3390/ijms22073318. 

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics.

Int J Mol Sci. 2021 Mar 8;22(5):2719. doi: 10.3390/ijms22052719. 

Immunostimulatory activity of polysaccharides extracted from Celosia cristata flowers.

Chem Biodivers. 2021 Mar 14. doi: 10.1002/cbdv.202100031. 

2020

Molecular Targeting of VEGF with a Suramin Fragment-DOCA Conjugate by Mimicking the Action of Low Molecular Weight Heparins.

Biomolecules. 2020 Dec 31;11(1):46. doi: 10.3390/biom11010046.

Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1.

Int J Mol Sci. 2020 Sep 13;21(18):6706. doi: 10.3390/ijms21186706.

Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation.

J Ethnopharmacol. 2020 Apr 6;251:112564. doi: 10.1016/j.jep.2020.112564. Epub 2020 Jan 10.

2019

The Molecular Links between Cell Death and Inflammasome.

Cells. 2019 Sep 10;8(9):1057. doi: 10.3390/cells8091057.

Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation.

J Ethnopharmacol. 2019 Jul 15;239:111917. doi: 10.1016/j.jep.2019.111917. Epub 2019 Apr 25.

Novel Small Molecule Inhibitors of Programmed Cell Death (PD)-1, and its Ligand, PD-L1 in Cancer Immunotherapy: A Review Update of Patent Literature.

Recent Pat Anticancer Drug Discov. 2019;14(2):100-112. doi: 10.2174/1574892813666181029142812.

2018

Programmed Cell Death in Immune Defense: Knowledge and Presumptions.

Immunity. 2018. 49(1):19-32. doi: 10.1016/j.immuni.2018.06.019.

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.

Cell Death Differ. 2018. 25(6):1107-1117. doi: 10.1038/s41418-018-0104-9. 

Identification and Characterization of NTB451 as a Potential Inhibitor of Necroptosis.

Molecules. 2018 Nov 5;23(11):2884. doi: 10.3390/molecules23112884.

Fermentation-Mediated Enhancement of Ginseng's Anti-Allergic Activity against IgE-Mediated Passive Cutaneous Anaphylaxis In Vivo and In Vitro.

J Microbiol Biotechnol. 2018 Oct 28;28(10):1626-1634. doi: 10.4014/jmb.1807.07057.

Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation.

Mediators Inflamm. 2018 Mar 4;2018:6054069. doi: 10.1155/2018/6054069. eCollection 2018.

Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation.

Evid Based Complement Alternat Med. 2018 Jan 18;2018:6346734. doi: 10.1155/2018/6346734. eCollection 2018.

Eucalyptus globulus Inhibits Inflammasome-Activated Pro-Inflammatory Responses and Ameliorate Monosodium Urate-Induced Peritonitis in Murine Experimental Model.

Am J Chin Med. 2018;46(2):423-433. doi: 10.1142/S0192415X18500210. Epub 2018 Feb 12.

Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination.

J Ethnopharmacol. 2018 Mar 1;213:159-165. doi: 10.1016/j.jep.2017.11.023. Epub 2017 Nov 21.

NLRP3 Inflammasome Activation Inhibitors in Inflammation-Associated Cancer Immunotherapy: An Update on the Recent Patents.

Recent Pat Anticancer Drug Discov. 2018;13(1):106-117. doi: 10.2174/1574892812666171027102627.

2017

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.

Sci Rep. 2017 Nov 8;7(1):15020. doi: 10.1038/s41598-017-15314-8.

Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models.

J Ethnopharmacol. 2017 Jun 9;205:173-177. doi: 10.1016/j.jep.2017.03.043. Epub 2017 Mar 24.

2016

Programmed necrosis in inflammation: Toward identification of the effector molecules.

Science. 2016 Apr 1;352(6281):aaf2154. doi: 10.1126/science.aaf2154.

Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.

Expert Opin Ther Pat. 2016 Nov;26(11):1239-1256. doi: 10.1080/13543776.2016.1230201. Epub 2016 Sep

Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation.

J Ethnopharmacol. 2016 Aug 22;190:91-9. doi: 10.1016/j.jep.2016.05.059. Epub 2016 May 31.

Development of an interleukin (IL)-33 sandwich ELISA kit specific for mature IL-33.

J Immunoassay Immunochem. 2016;37(6):585-96. doi: 10.1080/15321819.2016.1179645.

Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1.

Cytokine. 2016 Jul;83:33-40. doi: 10.1016/j.cyto.2016.03.013. Epub 2016 Mar 28.

Cichorium intybus Linn. Extract Prevents Type 2 Diabetes Through Inhibition of NLRP3 Inflammasome Activation.

J Med Food. 2016 Mar;19(3):310-7. doi: 10.1089/jmf.2015.3556.

2015

Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3 inflammasome activation.

Ethnopharmacol. 2015 Dec 24;176:424-8. doi: 10.1016/j.jep.2015.11.022. Epub 2015 Nov 10.

Anti-Inflammatory Action of an Antimicrobial Model Peptide That Suppresses the TRIF-Dependent Signaling Pathway via Inhibition of Toll-Like Receptor 4 Endocytosis in Lipopolysaccharide-Stimulated Macrophages.

PLoS One. 2015 May 27;10(5):e0126871. doi: 10.1371/journal.pone.0126871. eCollection 2015.

Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models.

Ethnopharmacol. 2015 Jul 21;170:81-7. doi: 10.1016/j.jep.2015.05.001. Epub 2015 May 11.

Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation.

Int J Mol Sci. 2015 Apr 10;16(4):8102-9. doi: 10.3390/ijms16048102.

Anti-inflammatory effect of Streptochlorin via TRIF-dependent signaling pathways in cellular and mouse models.

Int J Mol Sci. 2015 Mar 26;16(4):6902-10. doi: 10.3390/ijms16046902.

Syneilesis palmata (Thunb.) Maxim. extract attenuates inflammatory responses via the regulation of TRIF-dependent signaling and inflammasome activation.

J Ethnopharmacol. 2015 May 26;166:1-4. doi: 10.1016/j.jep.2015.02.056. Epub 2015 Mar 6.

A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):227-35. doi: 10.1016/j.taap.2015.02.006. Epub 2015 Feb 14.PMID: 25689174

2014

Concepts of tissue injury and cell death in inflammation: a historical perspective.

Nat Rev Immunol. 2014 Jan;14(1):51-9. doi: 10.1038/nri3561. 

Activation of the NLRP3 inflammasome by proteins that signal for necroptosis.

Methods Enzymol. 2014;545:67-81. doi: 10.1016/B978-0-12-801430-1.00003-2.

The in vivo significance of necroptosis: lessons from exploration of caspase-8 function.

Cytokine Growth Factor Rev. 2014 Apr;25(2):157-65. doi: 10.1016/j.cytogfr.2013.12.001. Epub 2013 Dec 24.

Concepts of tissue injury and cell death in inflammation: a historical perspective.

Nat Rev Immunol. 2014 Jan;14(1):51-9. doi: 10.1038/nri3561. Epub 2013 Dec 13.

Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-α secretion through protein kinase C and IκB kinase 2 signaling.

Eur J Pharmacol. 2014 Jan 15;723:501-6. doi: 10.1016/j.ejphar.2013.09.066. 

2013

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

Immunity. 2013 Jan 24;38(1):27-40. doi: 10.1016/j.immuni.2012.09.015. Epub 2012 Dec 20.

Lysimachia clethroides Duby extract attenuates inflammatory response in Raw 264.7 macrophages stimulated with lipopolysaccharide and in acute lung injury mouse model.

J Ethnopharmacol. 2013 Dec 12;150(3):1007-15. doi: 10.1016/j.jep.2013.09.056. Epub 2013 Oct 18.

Streptochlorin suppresses allergic dermatitis and mast cell activation via regulation of Lyn/Fyn and Syk signaling pathways in cellular and mouse models.

PLoS One. 2013 Sep 27;8(9):e74194. doi: 10.1371/journal.pone.0074194. eCollection 2013.

Carpesium macrocephalum attenuates lipopolysaccharide-induced inflammation in macrophages by regulating the NF-κB/IκB-α, Akt, and STAT signaling pathways.

Am J Chin Med. 2013;41(4):927-43. doi: 10.1142/S0192415X13500626.

Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages.

Food Chem Toxicol. 2013 Jul;57:256-61. doi: 10.1016/j.fct.2013.03.040. Epub 2013 Apr 15.

Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

Int Immunopharmacol. 2013 Apr;15(4):666-70. doi: 10.1016/j.intimp.2013.03.015. Epub 2013 Mar 25.