1st Definition: One who makes mistakes regularly; a failure. (Usually written as 'screw-up' when used as a noun.)
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Example: 1) Be careful when you're dealing with Charlie -- he's a real screw-up.
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2nd Definition: To make a major mistake.
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Example: 1) Tom screwed up the whole project, and now we're four weeks behind schedule.
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Etymology: This phrase comes from World War II US Army slang.
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