Re:Re: 스트레스와 cortisol, FDG micro PET neuroimaging

FDG micro PET neuroimaging으로 원광대 광주한방병원 교수님이 어마어마한 논문을 썼다. 세상에는 놀랄만한 일들이 참 많다. 한의사가 이런 논문을 쓸 수 있다는게 참으로 놀랍기만 하다.   panic bird....   <a href='javascript:fileFilterViewer("http://cfile248.uf.daum.net/attach/15752E1C49ABA3A8128A12", "/cfile248/15/752E1C49ABA3A8128A12", "neural responses in rat brain during acute immobilization s.pdf", "grpid%3Dz4ZG%26fldid%3DHCsV%26dataid%3D202%26fileid%3D1%26regdt%3D20090302181557&url=http%3A%2F%2Fcfile248.uf.daum.net%2Fattach%2F15752E1C49ABA3A8128A12")'><img src="https://t1.daumcdn.net/daumtop_deco/icon/icon.hanmail.net/editor/p_pdf_s.gif" border="0" alt="첨부파일" class="vam"/> neural responses in rat brain during acute immobilization s.pdf</a>     1: <A href="xxjavascript:AL_get(this, 'jour', 'Neuroimage.');">Neuroimage.</A> 2009 Feb 1;44(3):1074-80. Epub 2008 Oct 8.<A href="http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3048&itool=AbstractPlus-def&uid=18952183&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S1053-8119(08)01031-8" target=_blank> <IMG id=linkout-icon-def-PubMedLink alt="Click here to read" src="https://img1.daumcdn.net/relay/cafe/original/?fname=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcorehtml%2Fquery%2Fegifs%2Fhttp%3A--linkinghub.elsevier.com-ihub-images-PubMedLink.gif" border=0></A> <xSCRIPT language=xxJavaScript1.2></xSCRIPT> <A class=dblinks [안내]태그제한으로등록되지않습니다-xxonmouseout=PopUpMenu2_Hide(); href="xxjavascript:PopUpMenu2_Set(Menu18952183);" target=_self>Links</A>   Neural responses in rat brain during acute immobilization stress: a [F-18]FDG micro PET imaging study.   <DD class=abstract> <DIV class=authors><A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Sung%20KK%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Sung KK</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Jang%20DP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Jang DP</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lee%20S%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Lee S</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Kim%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Kim M</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lee%20SY%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Lee SY</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Kim%20YB%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Kim YB</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Park%20CW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Park CW</A>, <A href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Cho%20ZH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">Cho ZH</A>.</DIV> Department of Neuroscience and Oriental Medicine, Wonkwang University, Iksan, South Korea.</DD> <DD class=abstract>   We used the [F-18]FDG micro PET neuroimaging technique to investigate changes in brain activity induced by acute stress in rats. Animals were given immobilization stress for 1 or 2 h, or 1-h stress followed by 1-h recovery, after which their brains were scanned. Plasma corticosterone levels measured at various time points in separate groups of rats showed a rapid increase during stress and slower decrease after termination of the stress. </DD> <DD class=abstract>  </DD> <DD class=abstract> Immobilization stress given for an hour activated the hypothalamus, entorhinal and insular/piriform cortices, and raphe pallidus nucleus. </DD> <DD class=abstract>  </DD> <DD class=abstract> At the same time, the dorsal hippocampus, thalamus, other cortical areas (motor, somatosensory and barrel field), striatum, superior colliculus and cerebellum were deactivated. With 2-h immobilization stress, the activity of the hypothalamus, various cortical areas and dorsal hippocampus habituated during the second hour while that of the thalamus and cerebellum did not. During 1-h recovery, the hypothalamic activation and widespread cortical deactivation disappeared, but the dorsal hippocampus, thalamus and cerebellum still remained significantly deactivated. Additional brain areas such as the septum and prelimbic cortex now showed deactivation during recovery. </DD> <DD class=abstract>  </DD> <DD class=abstract> Changes in glucose metabolism in the dorsal hippocampus and hypothalamus exhibited a highly significant negative correlation, supporting the view that the hippocampus is involved in regulating the stress response of the hypothalamo-pituitary-adrenal axis. The advantages and limitations of the [F-18]FDG micro PET used in this study are discussed.</DD>