Re: electrostatic repulsive force를 유지하는 chondroitin sulfate 손실이 유발하는 osteoarthritis 논문

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chondroitin sulfate

프로테오글리칸의 화학적 구조와 물리적 상호작용은 ECM의 특성에 영향을 미친다. CS와 KS 사슬에서 가까이 위치해 있는 황산화와 카르복실기 전하를 띈 집단은 생리적인 pH상태에서 용액에 해리되어 고정된 음전하를 집중시킴으로써 분자내와 분자간의 전하간 강한 반발력이 작용하게 된다. 이러한 힘의 합산은 돈난 삼투압에 대응하게 된다. 이러한 전하대 전하의 반발력은 PG 거대분자를 주변의 교원질 망에 의해 형성된 섬유간 공간내에서 확장되고 강해지게 한다. 이러한 전하 반발력은 중력의 7백만배(?) 더 크다고 한다. 

논문 1.

Ann Rheum Dis. 2008 Jun;67(6):735-40. Epub 2007 Jul 20.

Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues.

Monfort J, Pelletier JP, Garcia-Giralt N, Martel-Pelletier J.

Source

Hospital del Mar, Passeig del Mar, Barcelona, Spain.

Abstract

Osteoarthritis is a chronic disease characterised by irreversible damage to joint structures, including loss of articular cartilage, osteophyte formation, alterations in the subchondral bone and synovial inflammation. Pain, functional disability and impairment of health-related quality of life are major complaints in patients with osteoarthritis. Several compounds have been investigated for their positive effects on the relief of clinical symptoms and improvement of structural changes in osteoarthritis. It has been shown that chondroitin sulphate interferes with the progression of structural changes in joint tissues and is used in the management of patients with osteoarthritis. This review summarises data from relevant reports describing the mechanisms of action of chondroitin sulphate involved in the beneficial effects of the drug.

논문 2.

osteoarthritis and cartilage.pdf

Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review

• J. Martel-Pelletier
, 
• S. Kwan Tat
, 
• J.-P. Pelletier

Received 7 October 2009; accepted 17 January 2010. published online 20 April 2010.

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Summary 

Objective

Osteoarthritis is a chronic disease characterized by irreversible damage to joint structures, including loss of articular cartilage, inflammation of the synovial membrane, and alterations in the subchondral bone. Symptomatic slow-acting drugs for osteoarthritis have been proposed as treatment because of their excellent safety profile. This review summarizes some data relating to the mechanisms of action of chondroitin sulfate in the pathophysiology of osteoarthritic joint tissues.

Methods

Peer-reviewed articles obtained using pre-defined search criteria and published in the PubMed database are summarized. In addition, a relevant in press paper is included.

Results

Chondroitin sulfate belongs to the group of glycosaminoglycans and is a major component of articular cartilage. The effect of chondroitin sulfate in patients with osteoarthritis is possibly the result of the stimulation of the synthesis of proteoglycans and the decrease in catabolic activity of chondrocytes by inhibiting the synthesis of proteolytic enzymes and other factors that contribute to cartilage matrix damage and cause the death of these cells. Chondroitin sulfate was also shown to exert anti-inflammatory activity. In addition, it acts on osteoarthritic subchondral bone osteoblasts by modulating the osteoprotegerin/receptor activator of NF-κB ligand ratio in favor of reduced bone resorption. It is noteworthy to mention that a head-to-head comparison of the effects of chondroitin sulfate of different origins and levels of purity on human osteoarthritic cartilage revealed the existence of a disparity in effects.

Conclusion

The positive effects of chondroitin sulfate on the pathophysiology of osteoarthritis are possibly due to its contribution to a proper balance between anabolism/catabolism in the articular tissues.

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