Re: 비만치료를 위한 침치료 논문

[문형철]

비만세포의 생노병사를 공부한 뒤

비만치료의 침치료에 대한 논문 몇편을 읽어야 겠다

panic bird......

Electroacupuncture in the Treatment of Obesity.pdf

결론

Evidence obtained from the rat experiment indicated that EA at body points for 30 min produced a significant
reduction of both food intake and the body weigh, with 2 Hz more effective than 100 Hz. EA could also produce a
reduction of plasma level of total cholesterol and triglyceride, with 100 Hz more effective than 2 Hz. The appetite
suppressive effect of 2 Hz EA is an immediate response, lasting no more than 24 h in the rat. 2 Hz EA stimulation
produced an increased expression‎ of the anorxigenic peptides aMSH and CART, and a decreased expression‎ of the
orexigenic peptide NPY in the arcuate nucleus of the hypothalamus (ARH) of the rat, which may account, at least in part, the decrease in appetite. EA seems not affecting the energy expenditure by AMPK–UCP3 pathway. An open trial in 16 over-weighted persons showed that 2 Hz transcutaneous electrical acupoint stimulation 3 times a week for 4 weeks produced a steady and significant decrease of body weight. EA resumed after a 4 week break remains effective.

1: Int J Obes (Lond). 2009 Feb;33(2):183-96. Epub 2009 Jan 13. Links

Acupuncture for obesity: a systematic review and meta-analysis.

Cho SH, Lee JS, Thabane L, Lee J.

Hospital of Korean Medicine, Kyung Hee University Medical Center, Seoul, Korea.

BACKGROUND AND OBJECTIVE: Acupuncture is widely used in complementary and alternative medicine to reduce body weight. However, a systematic review and meta-analysis to assess an effect of acupuncture has not yet been performed. Aim of this study is to critically assess evidence for reduction of body weight and to eval‎uate adverse events of acupuncture therapy based on the results of randomized controlled trials (RCTs) that eval‎uate the effect of various types of acupuncture therapies. DATA SOURCES: A total of 19 electronic databases, including English, Korean, Japanese and Chinese databases, were systematically searched for RCTs of acupuncture for reduction of body weight or improvement in obesity up to March 2008 with no language restrictions. METHODS: RCTs for acupuncture compared either with placebo controlled or with comparator intervention were considered. Studies' methodological qualities were assessed using the Jadad scale. If no evidence of heterogeneity existed across study results, statistical pooling of data was performed using a fixed effects model; otherwise, a random effects model was used. Publication bias was assessed using funnel plots. Subgroup analyses were performed according to types of acupuncture. RESULTS: A total of 31 studies, which comprised a total of 3013 individual cases, were systematically reviewed. Owing to insufficient data in 2 RCTs, 29 RCTs were used for meta-analysis. About two-thirds of the trials (20 out of 31) showed the lowest score of the Jadad. Compared to control of lifestyle, acupuncture was associated with a significant reduction of average body weight (95% confidence interval, CI) of 1.72 kg (0.50-2.93 kg) and associated with an improvement in obesity (relative risk=2.57; 95% CI, 1.98-3.34). Acupuncture significantly reduced a body weight of 1.56 kg (0.74-2.38 kg), on average, compared to placebo or sham treatments. Acupuncture also showed more improved outcomes for body weight (mean difference=1.90 kg; 1.66-2.13 kg), as well as for obesity (relative risk=1.13; 1.04-1.22), than conventional medication. Only four RCTs reported acupuncture-related adverse events, which were mostly minimal. CONCLUSIONS: Our review suggests that acupuncture is an effective treatment for obesity. However, the amount of evidence is not fully convincing because of the poor methodological quality of trials reviewed. In conclusion, there is an urgent need for well-planned, long-term studies to address the effectiveness of acupuncture for treating obesity.

1: Neurochem Res. 2008 Oct;33(10):2023-7. Epub 2008 Aug 22. Links

Electroacupuncture in the treatment of obesity.

Wang F, Tian DR, Han JS.

Neuroscience Research Institute, Peking University, Beijing 100083, People's Republic of China. wuling51@263.net

Obesity is becoming one of the most common health problems in the world. Many other disorders, such as hypertension and diabetes are considered as the consequences of obesity. Since effective remedies are rare (only two drugs, Orlistat and Sibutramine, were officially approved by the US Food and Drug Administration for long-term obesity treatment so far), researchers are trying to discover new therapies for obesity, and acupuncture is among the most popular alternative approaches. To facilitate weight reduction, one can use manual acupuncture, electroacupuncture (EA) or transcutaneous electrical acupoint stimulation (TEAS). As the parameters of the EA or TEAS can be precisely characterized and the results are more or less reproducible, this review will focus on EA as a treatment modality for obesity. Results obtained in this laboratory in recent five years will be summarized in some detail.

1: Zhen Ci Yan Jiu. 2007 Aug;32(4):264-7. Links

[Effect of electroacupuncture on leptin and adiponectin in simple obesity patients]

[Article in Chinese]

Luo HL, Li RH.

College of Chinese Medicine, Chongqing Medical University, Chongqing 400050, China. ally88@21cn.com

OBJECTIVE: To probe into the underlying mechanism of electroacupuncture (EA) for simple obesity patients. METHODS: Sixty simple obesity patients were randomly divided into control, manual acupuncture (MA) and EA groups with 20 cases in each group. Acupoint groups (1) Liangqiu (ST 34), Xuehai (SP 10), etc.; (2) Gongsun (SP 4), Neiting (ST 44), etc. were punctured respectively for MA groups (once every other day, 27 times altogether), and in combination with EA (2-5 mA, 0.8-3 Hz, 30 min) of bilateral Tianshu (ST 25), Fujie (SP 14), etc. for EA group. Serum leptin (Lep) and adiponectin (Adi) were measured by enzyme linked immunosorbent assay (ELISA). RESULTS: After the treatment, of the 20 cases in control, MA and EA groups, 0 (0%), 0(0%) and 4 (20. 0%) were cured; 0 (0%), 10 (50.0%) and 14 (70.0%) were improved remarkably; 1 (5.0%), 7 (35.0%) and 1 (5.0%) were effective; 19 (95.0%), 3 (15.0%) and 1 (5.0%) failed, with the effective rates being 5.0%, 85.0% and 95.0% separately. The therapeutic effects of both MA and EA groups were significantly higher than that of control group (P < 0.01). After the treatment, serum Lep levels in both MA and EA groups decreased significantly, and serum Adi contents of these two groups increased considerably compared with their own basic values of pre-treatment (P < 0.05, 0.01), and the effects of EA were markedly better than those of MA and control groups (P < 0.05). No significant changes were found in Lep and Adi levels in control group (P > 0.05). CONCLUSION: Both EA and manual acupuncture can effectively lower blood Lep content and raise blood Adi in simple obesity patients, which may contribute to its effect in reducing body. weight. The effect of EA is significantly superior t o that of manual acupuncture in the treatment of simple obesity.

1: Am J Chin Med. 2008;36(6):1029-39. Links

The efficacy of electroacupuncture therapy for weight loss changes plasma lipoprotein A, apolipoprotein A and apolipoprotein B levels in obese women.

Cabioglu MT, Gündogan N, Ergene N.

Department of Physiology, Medical Faculty, Başkent University, Ankara, Turkey. tugcab@yahoo.com

In the present study, we aimed to investigate the effects of electroacupuncture treatment on lipoprotein A, apolipoprotein A and apolipoprotein B levels in obese subjects. Fifty-eight women were studied in 3 groups as follows: 1) Placebo acupuncture (n = 15; mean age = 41.47 +/- 4.61, and mean body mass index {BMI} = 33.43 +/- 3.10); 2) Electroacupuncture (EA) (n = 20; mean age = 40.55 +/- 5.30, and BMI = 35.65 +/- 3.84) and 3) Diet restriction groups (n = 23; mean age = 42.91 +/- 4.02, and BMI = 34.78 +/- 3.29). EA was performed using the ear points, Hungry, Shen Men and Stomach the body points, Hegu (LI 4), Quchi (LI 11), Tianshu (St 25), Zusanli (St 36), Neiting (St 44) and Taichong (Liv 3) for 20 days. Intragroup comparisons were made by using paired samples t-test whereas intergroup differences were investigated by the two-way variation analysis and LSD test. There was a 4.7% (p < 0.001) weight reduction in patients with electroacupuncture application, whereas patients in diet restriction had a 2.9% (p < 0.001) weight reduction. There were significant decreases in lipoprotein A (p < 0.05) and apolipoprotein B (p < 0.05) levels in the EA compared to the control group and no changes in apolipoprotein A levels was observed in EA, diet and placebo acupuncture groups. EA therapy may be a useful approach for the treatment of obesity for both losing weight and lowing the risk factors for cardiovascular disease associated with obesity, since this application may decrease the plasma lipoprotein A and apolipoprotein B levels.