대창90년사:박사,장광호(3)

[장병창]

  Tiletamine/zolazepam 마취견에서 전침자극이 순환기계에 미치는 영향(Tiletamine/zolazepam 痲醉犬에서 전침刺戟이 循環기계에 미치는 影響 =Effects of Electroacupuncture at Some Acupoints on the Cardiovascular System in Dogs Anesthetized with Tiletamine/zolazepam) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(강한샘 장환수 이문학 엄기동)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2003년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.20 No.2 224-228쪽(5쪽 分量)에 수록되어 있다. 제어번호 40037822, KDC 528이다. [초록] : This study was performed to eval‎uate the effect of electroacupuncture at some acupoint combinations on the cardiovascular system, especially on blood pressure. Electroacupuncture at acupoint combinations of GV20(＋)/GV-16(－), 4(＋)/GV-16(－), KI1(＋)/GV20(-), and HT9(＋)/GV16(－) did not changed heart rates and blood pressure, but stimulation of HT1(＋)/HT7(－) increased ystolic, diastolic and mean arterial blood pressure significantly in dogs anesthetized with tiletamine/zolazepam.(keris 2006)

  랫드에서 고농도의 Carboxymethyl Chitosan이 복벽 유착 예방에 미치는 영향(랫드에서 高濃度의 Carboxymethyl Chitosan이 腹壁 癒着 豫防에 미치는 影響 =Effect of high concentrations of carboxymethyl chitosan on preventing formation of peritoneal adhesion in rats) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(권영삼 장환수 정재훈 배재성 이정우 강한샘 양정훈 이문학)의 논문으로, 대한수의학회(URL  http://www.ksvs.or.kr/)에서 2003년에 발행한 <대한수의학회지(大韓獸醫學會誌)> Vol.43 No.1 151-156쪽(6쪽 分量)에 수록되어 있다. 제어번호 30081706, KDC 528이다. [초록] : The objective of this study was to determine the effective concentration of carboxymethyl chitosan(CMC) solution on preventing intraperitoneal adhesions. In this study, 60 rats were divided into four groups : an untreated control group and three experimental groups that were treated with 3 ml of 3, 5, and 7% CMC solution. Adhesions were induced by suturing both the ideal serosa and peritoneum scarped until petechial bleeding occurred. CMC solutions were instilled intraperitoneally immediately before closure until petechial bleeding occurred. CMC solutions were instilled intraperitoneally immediately before closure of the peritoneomuscular layer. The tensile strength of formed adhesions was measured by using a computerized tensiometer. Histopathological changes of adhesions were eval‎uated by hematoxylin-eosin for light microscopic examination and Massons's trichrom staining for collagen fibers. All of CMC solutions reduced significantly the tensile strength of the adhesions. CMC inhibited the increase of inflammatory cell infiltration and damage of adhesion spot, and accelerated the collagen synthesis and neovascularization. No significant differences were observed among all of CMC concentration at inhibiting adhesion formation. Therefore, we could conclude that 3% CMC, the lowest concentration adopted in this study, was appropriate to prevent the formation of peritioneal adhesion.(keris 2006)

  개에서 비강내 종양 27 증례(개에서 鼻腔內 腫瘍 27 證例 =Intranasal tumor in 27 dogs) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(권영삼 장인호)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2002년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.19 No.3 383-386쪽(4쪽 分量)에 수록되어 있다. 제어번호 19743384, KDC 528이다. [초록] : Intranasal tumors were diagnosed in 27 dogs for 5 years. Sneezing, nasal discharge, nasal bleeding were the most common clinical signs. Diagnosis was perform by blood test, histological examination, radiography, and computed tomography, Among the 27 nasal tumors, adenocarcinomas, squamous cell carcinomas, and chondrosarcomas were relatively common. Breeds with nasal tumor were shetland sheepdog, mongrel, and shiba. The dogs were treated by surgical resection, radiotherapy, chemotherapy, cryosurgery, and radiofrequency ablation. Each therapy alone was not effective, but the combination of two or more therapies had good effects on progression of tumor and made the survival time extended.(keris 2006)

  개에서 방광내 이행세포암종의 초음파학적 진단(개에서 膀胱內 移行細胞癌腫의 超音波學的 診斷 =Ultrasonographic Findings of Transitional Cell Carcinoma in a Dog) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(엄기동 오태호 이영원 장동우 이기창 윤정희)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2002년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.19 No.2 268-271쪽(4쪽 分量)에 수록되어 있다. 제어번호 19743333, KDC 528이다. [초록] : Transitional cell carcinoma(TCC) was identified by cytological and ultrasonographic findings in an 11-year-old, intact female Yorkshire terrier with intermittent hematuria for three years. In color-doppler ultrasound images there was marked irregular wall thickness of the bladder surface and well-defined hyperechoic focal lesions within the mass. Active vascular response was observed in the surroundings of hyperechoic lesions.(keris 2006)

  개에서 Propofol 점적 투여율 변화가 심혈 관계에 미치는 영향(개에서 Propofol 점적 投與率 變化가 心血 關係에 미치는 影響 =Cardiovascular Effects of Propofol Infused for Maintenance of Anesthesia in Dogs) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(권영삼 장환수 박현정 임재현 엄기동 장인호 오태호)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2002년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.19 No.2 199-203쪽(5쪽 分量)에 수록되어 있다. 제어번호 19743297, KDC 528이다. [초록] : Cardiovascular effects of propofol, were assessed after premedication with xylazine(1.0 ㎎/㎏, IM) under oxygen supply(200 ml/㎏/min) via a endotracheal tube. Twelve adult mixed-breed dogs were divided into four groups; 0.2(Group 1), 0.4(Group 2), 0.6(Group 3) and 0.8 ㎎/㎏/min(Group 4) of propofol respectively. Arterial blood pressure and electrocardiogram were monitored with a physiograph after an arterial catheter was inserted into the femoral artery. pH, arterial carbon dioxide tension(PaCO_2) and arterial oxygen tension(PaO_2) were eval‎uated with arterial blood collected through the inserted catheter. Diastolic arterial pressure, systolic arterial pressure and mean arterial pressure were decreased slightly in Group Ⅰ, Ⅱ and Ⅲ, but decreased significantly in Group Ⅳ. They were increased rapidly after stopping propofol infusion in Group Ⅳ pH was maintained in normal range in Group Ⅰ, Ⅱ and Ⅲ, but was decreased in proportion to time passing in Group Ⅳ PaCO_2 was increased significantly only in Group Ⅳ, but PaO_2 was maintained in normal range in all groups. Although heart rate was recorded in normal range for 90 minutes, arrythmia was noted after stopping propofol infusion in all groups. It was concluded that propofol depressed the cardiovascular system in proportion to infusion dosage, and 0.8 ㎎/㎏/min of propofol infusion rate was not appropriated in canine anesthesia with xylazine premedication.(keris 2006)

  Yohimbine과 Atipamezole이 Xylazine-Ketamine 병용 마취견의 뇌파에 미치는 영향(Yohimbine과 Atipamezole이 Xylazine-Ketamine 倂用 痲醉犬의 腦波에 미치는 影響 =Effects of Yohimbine and Atipamezole in Dogs Anesthetized with Xylazine-Ketamine Combination on EEG) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(장인호 장환수 이만기)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2002년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.19 No.2 174-185쪽(12쪽 分量)에 수록되어 있다. 제어번호 19743288, KDC 528이다. [초록] : We investigated the effects of yohimbine and atipamezole in dogs anesthetized with xylazine-ketamine combination on electroencephalography(EEG). Experiment groups were divided into three according to antagonists. Saline (1 ml) was used as an antagonist in group C, yohimbine (0.1 ㎎/㎏) in group Y and atipamezole (50 ug/㎏) in group A. Each group consisted of 5 dogs. Glycopyrrolate was injected 15 minutes prior to xylazine injection. Xylazine (1.1 ㎎/㎏, IM) and ketamime (10 ㎎/㎏, Ⅳ) were injected with the interval of 10 minutes. After 15 minutes, antagonists were administered intravenously. For EEG measurements, a recording electrode was positioned at Cz, which was applied to International 10-20 system. Heart rates, body temperature, respiratory rates, arterial blood pressure, PaO_2, PaCO_2, electrolytes analysis(Na, K, CI), and behavioral changes were also measured. Results were recorded at every 4 stages(S1: before xylazine injection, S2: 10 minutes after xylazine injection, S3: 15 minutes after ketamine injection, S4: prior to the dog showing head-up movement after antagonist injection). All results were compared with those of S I. In the power bands(Bandl; 1-2.5 ㎐, Band2; 2.5-4.5 ㎐, Band3; 4-8 ㎐, Band4; 8-13 ㎐, Bands; 13-20 ㎐, Band6; 20-30 ㎐, Band7; 30-50 ㎐, Band8; 1-50 ㎐), the changes of band 1, 2, 3 and 4 were not significant in all groups. In group C, band 7 at S2, band 5, 6 and 7 at S3 and band 8 at S2 were significantly decreased(p < 0.05). In group Y, band 7 at S2 and 5, 6 and 7 at S3 were significantly decreased(p < 0.05). In group A, band 5, 6 and 7 at S2, S3 and S4, and band 8 at S4 were significantly decreased(p < 0.05). In group A, the band power of band 5, 6 and 7 at S4 were still significantly decreased state in spite of dogs showing head-up movement and this finding was different from those of group C and Y. Temperatures, heart rates and respiratory rates were gradually decreased after xylazine and ketamine administration. Temperatures were not antagonized in spite of antagonist injection in all groups. Heart rates were increased after antagonist injection in group Y and A. Respiratory rates were increased after antagonist injection in all groups. In group C, systolic arterial pressure(SAP), diastolic arterial pressure(DAP) and mean arterial pressure(MAP) at S3, and SAP and MAP at S4 were significantly decreased(p<0.05). In group Y, SAP at S3 and DAP and MAP at S4 were significantly decreased(p < 0.05). In group A, SAP, DAP and MAP at S2, SAP at S3 were significantly decreased(p < 0.05), but significant chages did not occur at S4. In blood gas analysis, only, PaCO_2 at S4 in group Y was significantly decreased(p<0.05). Changes of electrolytes were not significant, except value of Cl- at S3 in group A. Mean head-up time (the time dogs showing head-up movement after antagonist injection, minutes) was 38.23°ae6.46 in group C, 2.54 0.93 in group Y and 2.12 1.32 in group A. Mean sternal recumbent time (the time dogs showing sternal recumbency after antagonist injection, minutes) was 45.93 10.27 in group C, 11.91 7.19 in group Y and 9.88 3.38 in group A. Mean walking time (minutes) was 53.49 9.21 in group C, 22.10 11.10 in group Y and 18.48 4.39 in group A. In group Y, all dogs showed excitation and muscle rigidity in emergence. In group A, two dogs were also showed excitation and muscle rigidity, but were weaker than those of group Y.(keris 2006)

  개의 골신연술에서 키토산과 황화칼슘합제가 조기 골경화에 미치는 영향(개의 골신연술에서 키토산과 황화칼슘 合劑가 早期 骨硬化에 미치는 影響 =Effect of Chitosan-Calcium Sulfate Mixture on Early Bony Consolidation in Osteodistracted Dogs) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(강원모 장인호)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2002년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.19 No.2 165-173쪽(9쪽 分量)에 수록되어 있다. 제어번호 19743286, KDC 528이다. [초록] : The purpose of this study was to eval‎uate the effect of chitosan-calcium sulfate mixture on early bony consolidation in osteodistracted dogs. The experimental group was divided into 3 groups: saline group(Control), chitosan group(Group CH) and chitosan-calcium sulfate mixture group(Group CH+CS). Four dogs were allocated to each group and classified into 3 week observation subgroups and 5 week observation subgroups, respectively. Two dogs were allocated to each subgroup. The lateral surface of the left mandibular body was exposed in the subperiosteal plane and vertical osteotomy was carried out on the mandibular body. An external distraction device was applied to the mandibular body. Mandibular distraction was started 5 days after the osteotomy at a rate of 1 mm per day for a total of 10 mm distraction for 10 days. After completion of distraction, chitosan, chitosan-calcium sulfate and saline were injected into the distracted zone of the group CH, group CH+CS and control. The external device was left in place for 3 or 5 weeks to allow for bony consolidation. Serial radiographs were carried out every week. Two dogs of each group, six dogs in total, were sacrificed at 3 weeks, and the other six dogs at 5 week after distraction. Bone specimens of the distracted mandibles were taken for histologic examination. New bone was not noted in the distracted zone of 3 week observation subgroups in the control and group CH. However, new bone was developed in the group CH+CS with a narrow fibrous interzone in the area of the distracted zone. While osteogenesis was mild in the margin of the distracted zone of 5 week observation subgroup in the control, new bone was noted much in the group CH and group CH+CS. However, osteogenesis was noted more significantly in the group CH+CS than that of group CH. In conclusion, chitosan-calcium sulfate mixture was more effective on early bony consolidation in distraction osteogenesis(keris 2006)

  개에서 심방중격결손의 증례(개에서 심방중격 缺損의 證例 =Atrial Septal Defect in Dogs) [學術저널] : 호명면 담암리 담바우 출신인 장광호(張洸鎬, 大昌高 卒業, 慶北大 敎授) 등(엄기동 오태호 이영원 윤정희 정주현 장동우)의 논문으로, 한국임상수의학회(URL  http://www.ksvc.or.kr)에서 2002년에 발행한 <한국임상수의학회지(韓國臨床獸醫學會誌)> Vol.19 No.1 110-113쪽(4쪽 分量)에 수록되어 있다. [초록] : An atrial septal defect (ASD) is a congenital hole in the atrial septum that allows flow between the two atria. Small ASDs are usually well-tolerated defects and do not result in significant clinical abnormalities. In large ASDs or in the presence of other cardiac defects, clinically significancy is increased. Atrial septal defects in 2 Dogs with cardiac and respiratory signs were diagnosed at seoul animal medical center. In ascultation, systolic murmur and the splitting of second heart sound were heard at pulmonary or tricuspid valve region. In radiograph, right-sided cardiomegaly, pulmonary artery dilation, increased pulmonary vasculature makings, and pleural effusion or pulmonary edema signs were observed. In echocardiography, the region, location and size of septal defect was identified. Also, the direction and degree of shunt was measured. These dogs were treated with medicine for cardiac failure. One dog is well-tolerated, the other dog died.(keris 2006)