| The most popular JAMA articles published in 2025 |
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Original Investigation
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial
Christopher X. Wong, MBBS, MPH, PhD; Christopher C. Cheung, MD, MPH; Gabrielle Montenegro, BA; et al
Recommendation Statement
Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force
Special Communication
Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines
Ryan A. Metcalf, MD; Susan Nahirniak, MD; Gordon Guyatt, MD; et al
Review
Management of Staphylococcus aureus Bacteremia: A Review
Steven Y. C. Tong, MBBS, PhD; Vance G. Fowler Jr, MD, MHS; Lesley Skalla, PhD, MSLS; et al
Review
Iron Deficiency in Adults: A Review
Michael Auerbach, MD; Thomas G. DeLoughery, MD; Jennifer S. Tirnauer, MD
Original Investigation
A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease
COPDGene 2025 Diagnosis Working Group and CanCOLD Investigators
Review
Diagnosis and Treatment of Type 2 Diabetes in Adults: A Review
Rita R. Kalyani, MD, MHS; Joshua J. Neumiller, PharmD, CDCES; Nisa M. Maruthur, MD, MHS; et al
Original Investigation
Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial
Laura D. Baker, PhD; Mark A. Espeland, PhD; Rachel A. Whitmer, PhD; et al
Review
Osteoporosis: A Review
Suzanne N. Morin, MD, MSc; William D. Leslie, MD, MSc; John T. Schousboe, MD, PhD
Review
Prostate Cancer: A Review
Ruben Raychaudhuri, MD; Daniel W. Lin, MD; R. Bruce Montgomery, MD
Original Investigation
Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: The HOPE Randomized Clinical Trial
Ying Zhou, PhD; Yaode He, MD; Bruce C. V. Campbell, PhD; et al
Original Investigation
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial
The ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN)