심장병, 동맥경화, 중풍 가족력이 있는 사람에게 가장 중요한 검사 호모시스테인에 대하여

[문형철]

beyond reason

치유는 기쁨, 감사, 축복 540 치유의 에너지 장에서 일어난다.

어떤 사람에게는 좋은 음식이 어떤 사람에게는 독이 된다. 

기능의학에서 호모시스테인 수치를 7이하로 권장함.

호모시스테인 수치가 높으면 산화스트레스, 혈관 염증, 동맥경화, 심장병의 위험도가 높음. 

호모시스테인(Homocysteine)은 설파기를 포함한 아미노산으로 필수 아미노산인 Methionine (메티오닌)의 대사과정에서 생성

- 즉 탄수화물 금지식이를 하는 과정에서 육식을 많이 하면 호모시스테인이 높아질 가능성이 있음.

비타민 B6,9,12를 잘 복용하고 혈액검사로 점검해야!!

1) 호모시스테인은 혈액검사로 확인

2) 고호모시스테인의 결과는 동맥경화, 심장병, 산화스트레스

3) 호모시스테인의 대사

호모시스테인(Homocysteine)은 설파기를 포함한 아미노산으로 필수 아미노산인 Methionine (메티오닌)의 대사과정에서 생성된다. 호모시스테인은 재메틸화(remethylation)과정으로 Methionine synthase에 의해 메티오닌으로 재합성되며, 이 과정에서 비타민B12 (cobalamin) 가 보조인자로 작용한다. 

4) 고호모시스테인 혈증의 6가지 원인

# 메티오닌이 많은 동물성 단백을 과다 섭취하는 것도 호모시스테인의 증가를 가져올 수 있음

# 비타민 B6, 9, 12가 부족할때 고호모시스테인혈증이 발생할 수 있음. 

# 호모시스테인 대사와 관련된 유전적 결함(CBS, MTHFR, methione synthase결핍)

# 만성신부전, 크레아티닌의 증가, 갑상선기능저하, 악성빈혈, 유방암, 난소암, 췌장암, 백혈병 등

# methotrexate, sulfasalazine, phenytoin, theophylline, 경구피임약 등의 약물

# 흡연

Clin Chem Lab Med. 2011 Mar;49(3):479-83. doi: 10.1515/CCLM.2011.062. Epub 2010 Dec 14.

Effect of cigarette smoking on plasma homocysteine concentrations.

Haj Mouhamed D1, Ezzaher A, Neffati F, Douki W, Najjar MF.

Author information

1

Laboratory of Biochemistry-Toxicology, University Hospital of Monastir, Monastir, Tunisia. hajdhouha@yahoo.fr

Abstract

BACKGROUND: 

Cigarette smoking has been recognized as a major risk factor for cardiovascular disease, while the role of homocysteine is still not clear. This study investigated the effects of smoking on plasma homocysteine concentration and determined the correlation between this parameter and biological markers of tobacco use, such as plasma thiocyanate and urine cotinine.

METHODS: 

Folate, vitamin B12 and homocysteine were measured in 300 subjects: 138 non-smokers and 162 smokers using immunoassay methods. Cotinine was measured using an enzymatic colorimetric method and thiocyanate by a selective electrode.

RESULTS: 

In smokers, we found a significant increase in homocysteine and a decrease in folate and vitamin B12 levels compared to non-smokers. Homocysteine was strongly correlated with the duration of use and the number of cigarettes consumed. Folate and vitamin B12 were significantly reduced in subjects smoking for more than 20 years compared to those who smoked less than 5 years. Among smokers, we noted a positive correlation between homocysteine and both plasma thiocyanates and cotininuria, and a negative-correlation between cotininuria and plasma folate.

CONCLUSIONS: 

Cigarette smoking increases homocysteine, which is strongly correlated with cotininuria and plasma thiocyanates. Moreover, smokers had tendency to develop hypofolatemia and hypovitamin B12, particularly when the duration of consumption exceeded 20 years.

참고) 남자가 여자보다 혈중 호모시스테인 농도 25% 높음

       여성호르몬 치료는 호모시스테인 농도를 낮춤. 

5) 호모시스테인 검사정보

클릭클릭

참고) 알콜과 커피는 호모시스테인 수치를 올림

       운동은 호모시스테인 수치를 내려주고

클릭클릭 - 논문 읽어야

참고1) In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and the biological sciences.In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression‎, regulation of protein function, and RNA processing. In vitro methylation of tissue samples is also one method for reducing certain histological staining artifacts. The counterpart of methylation is called demethylation. 

참고2) Transmethylation is a biologically important organic chemical reaction in which a methyl group is transferred from one compound to another. An example of transmethylation is the recovery of methionine from homocysteine. In order to sustain sufficient reaction rates during metabolic stress, this reaction requires adequate levels of vitamin B₁₂ and folate. Methyl tetrahydrofolate delivers methyl groups to form the active methyl form of vitamin B₁₂ that is required for methylation of homocysteine. Deficiencies of vitamin B₁₂ or folate cause increased levels of circulating homocysteine. Elevated homocysteine is a risk factor for cardiovascular disease and is linked to the metabolic syndrome (insulin insensitivity).^[1]

Transmethylation is decreased sometimes in parents of children with autism.^[2]