Neuronal tracing. 말초신경의 소통과정

[문형철]

말초신경은 cell body와 axon terminal이 잘 소통해야 한다. 

인간사에서도 조직의 소통만큼 중요한 것이 없듯이, 말초신경의 소통은 중요하다. 

인간은 언어와 느낌으로 소통하는데, 말초신경은 어떤 원리에 의해 1m가 넘는  cell body와 axon terminal이 소통을 하는 것일까?

중요한 용어가 neuronal tracing, axonal transport이다. 

피부에 염증을 일으킨 헤르페스 virus가 retrograde transport 기전을 통해 cell body까지 도달하는데 걸리는 시간은 하루에 10-20cm씩 이동할 수 있다.

10일동안 1-2미터를 이동한다는 뜻. 

panic bird...

Neuronal tracing.pdf

ABSTRACT

The tracing of neural pathways continues to be an important concern for neuroanatomy. During the second half of the nineteenth century, at a time when the foundations of neuroanatomy were being established, tracing pathways often required laborious dissections by hand. Then, neuroanatomy experienced a methodological revolution in the beginning of the 1970s with the development of powerful techniques based on the axonal transport of tracers.

- 신경해부학을 위한 중요한 한가지는 tracing of neural pathways.

- ....

Axonal tracing of neuronal pathways using anterograde and retrograde transport is available. Axonal transport can be combined with immunohistochemistry for the neurochemical characterization of specific neuronal pathways. After tracing, tissue is collected following appropriate survival time for the tracer to be transported. Immunohistochemical methods, virus immunolabeling or autoradiography at the axon terminals are used for expressing the tracers. Retrograde axonal transport is used by certain viruses (e.g., herpes and pseudorabies virus) tob spread from one neuron to the next in a chain of neurons (transneuronal transfer). It is also the method whereby toxins (e.g., tetanus) are transported from the periphery into the central nervous system. This has led to the idea that viral tracing may be an important way as a possible gene delivery method for the gene therapy in nervous system diseases.

- anterograde 와 retrograde 이동

- 축삭이동은 ...

- 예를들어 피부에 염증을 일으킨 헤르페스 virus가 retrograde transport 기전을 통해 cell body까지 도달하는데 걸리는 시간은 하루에 10-20cm씩 이동할 수 있으니 계산해보면 안다.