Re: 건선 .. 6개월만에 완치한 케이스 논문..

[문형철]

https://www.youtube.com/watch?v=uLsCBxlnQK4

https://cafe.daum.net/panicbird/S3Cq/307

Re: 백반, 건선을 치료하는 고농도 비타민 D 3 치료법 - 논문 읽어야

Exp Ther Med. 2015 Sep; 10(3): 1071–1073.

Published online 2015 Jul 8. doi: 10.3892/etm.2015.2631

PMCID: PMC4533159

PMID: 26622441

Efficacy of nutritional treatment in patients with psoriasis: A case report

ANG PENG WONG,1 TATIANA KALINOVSKY,2 ALEKSANDRA NIEDZWIECKI,2 and MATTHIAS RATH2

Author information Article notes Copyright and License information PMC Disclaimer

This article has been corrected. See Exp Ther Med. 2020 February; 19(2): 1136.

Go to:

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by thickened, silvery-scaled patches. There is currently no cure and treatments only attempt to reduce the severity of symptoms. This study reports the case of a 36-year-old female who presented to the clinic with severe psoriasis and had been treated with topical steroid cream for the past 14 years. After adherence to prescribed dietary changes for 6 months, including abundant intake of vegetables, minimal consumption of meat, and avoidance of junk food and sugar in food or drinks, as well as nutritional supplementation with Vitacor Plus, ProLysinC, VitaCforte and LysinC Drink mix, the patient experienced complete resolution of psoriatic patches on her body.

건선은 

두꺼워진 은빛 비늘 모양의 패치가 특징인 

만성 염증성 피부 질환입니다. 

현재 완치법은 없으며 

증상의 심각성을 줄이기 위한 치료법만 시도되고 있습니다. 

이 연구는 

지난 14년 동안 

국소 스테로이드 크림으로 치료받던 36세 여성이 

중증 건선으로 병원을 찾은 사례를 보고합니다. 

6개월 동안 

채소를 충분히 섭취하고 

육류 섭취를 최소화하며 

정크푸드와 설탕이 함유된 음식이나 음료를 피하는 등 

처방된 식이 변화를 준수하고 V

itacor Plus, ProLysinC, VitaCforte 및 LysinC 음료 믹스로 영양 보충을 한 결과 

환자는 몸에 생긴 건선 패치가 완전히 해결되는 것을 경험했습니다.

Keywords: nutrients, psoriasis, case report

Go to:

Introduction

Psoriasis is a chronic inflammatory skin disease characterized by thickened, silvery-scaled patches. It has been associated with inflammatory and immune mechanisms probably associated with a genetic predisposition that can be triggered by stress (1,2). Psoriasis is one of the most common chronic inflammatory skin disorders, affecting ~2% of the general population (3). Psoriasis can substantially affect quality of life of patients. Numerous different treatments are available, which may allow short-term improvement and long-term control of the disease, but these measures do not cure psoriasis (4). Treatments include topical applications, systemic therapies and phototherapy; while they can be effective, a number of treatments are associated with significant adverse effects. Thus, there is a requirement for effective affordable therapies with fewer side effects that address the causes of the disorder.

Psoriasis is considered to be a T-cell-mediated inflammatory skin disease, which is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. While susceptibility to psoriasis is inherited, the disease is influenced by environmental factors, such as infections and stress (5). Diet has been suggested to be involved in the aetiology and pathogenesis of psoriasis (6,7). Fasting periods, low-energy diets and vegetarian diets have been shown to improve psoriasis symptoms in certain studies (6), and diets rich in polyunsaturated fatty acids from fish oil have also shown beneficial effects (7). These diets modify the polyunsaturated fatty acid metabolism and influence the eicosanoid profile, so that inflammatory processes are suppressed (6,7).

건선은 두꺼워진 은빛 비늘 모양의 패치가 특징인 만성 염증성 피부 질환입니다. 건선은 스트레스에 의해 유발될 수 있는 유전적 소인과 관련된 염증 및 면역 메커니즘과 관련이 있는 것으로 알려져 있습니다(1,2). 건선은 가장 흔한 만성 염증성 피부 질환 중 하나로, 일반 인구의 약 2%에 영향을 미칩니다(3). 건선은 환자의 삶의 질에 상당한 영향을 미칠 수 있습니다. 건선을 단기적으로 개선하고 장기적으로 관리할 수 있는 다양한 치료법이 있지만, 이러한 방법으로 건선을 완치할 수는 없습니다(4). 치료법에는 국소 도포, 전신 요법 및 광선 요법이 포함되며, 효과적일 수 있지만 많은 치료법이 심각한 부작용과 관련이 있습니다. 따라서 장애의 원인을 해결하면서 부작용이 적고 저렴한 비용으로 효과적인 치료법이 요구되고 있습니다.

건선은 

T세포 매개 염증성 피부 질환으로 

표피 각질 세포의 과증식 및 분화 불량으로 특징지어지는 질환으로 알려져 있습니다. 

건선에 대한 감수성은 유전되지만, 

건선은 감염 및 스트레스와 같은 환경적 요인에 의해 영향을 받습니다(5). 

식단은 

건선의 원인과 발병에 관여하는 것으로 알려져 있습니다(6,7). 

금식 기간, 

저에너지 식단 및 채식주의 식단은 

특정 연구에서 건선 증상을 개선하는 것으로 나타났으며(6), 

피쉬 오일의 고도 불포화 지방산이 풍부한 식단도 

유익한 효과가 있는 것으로 나타났습니다(7). 

이러한 식단은 

고도 불포화 지방산 대사를 수정하고 에

이코사노이드 프로필에 영향을 미쳐 염증 과정을 억제합니다(6,7).

Go to:

Case report

Written informed consent was obtained from the patient. A 36-year old female presented to the clinic with psoriasis since the age of 22. She stated that her outbreak of psoriasis originated on the scalp and slowly descended downward towards her feet. Eventually the psoriatic lesions covered a large extent of her body, with the exception of her face (Fig. 1). She had been prescribed topical steroid cream for the past 14 years. Possible cause could be due to usage of anti-dandruff shampoo (which contains coal tar) since teenage years. The patient stopped using the anti-dandruff shampoo upon the first consultation. Stopping the shampoo would not alleviate psoriasis in the time limits of the present study, but may help hasten the recovery.

환자로부터 서면 동의서를 받았습니다. 36세 여성이 22세부터 건선이 발생하여 클리닉에 내원했습니다. 그녀는 건선이 두피에서 시작되어 발 쪽으로 천천히 내려왔다고 말했습니다. 결국 건선 병변은 얼굴을 제외한 몸의 대부분을 덮었습니다(그림 1). 

그녀는 지난 14년 동안 국소 스테로이드 크림을 처방받았습니다. 

10대 때부터 비듬 방지 샴푸(콜타르 함유)를 사용한 것이 원인일 수 있습니다. 

환자는 첫 상담 즉시 비듬 방지 샴푸 사용을 중단했습니다. 

샴푸를 중단한다고 해서 본 연구의 제한적인 기간 동안 건선이 완화되지는 않았지만 회복을 앞당기는 데 도움이 될 수 있습니다.

Figure 1.

Image of the patient's back prior to nutritional treatment.

At the start of treatment, the patient was advised to consume a healthy diet with abundant vegetables, minimal meat, no junk food, and to avoid taking any forms of sugar in food or drinks. The following supplements were prescribed: Vitacor Plus-1 tablet 3 times daily, ProLysinC-2 tablets 3 times daily, VitaCforte-2 tablet 3 times daily, and LysinC Drink mix-1 scoop 4 times daily. Table I shows the list of components in these supplements. The patient was advised to stop using the steroid cream immediately at the beginning of treatment. Return appointments were scheduled once per month.

치료를 시작할 때 환자는 

풍부한 채소, 

최소한의 육류, 

NO 정크 푸드

건강한 식단을 섭취하고

음식이나 음료에 어떤 형태의 설탕도 섭취하지 않도록 조언을 받았습니다.

다음과 같은 보충제가 처방되었습니다:

비타코어 플러스 1정 1일 3회,

프로라이신씨 2정 1일 3회,

비타씨포르테 2정 1일 3회, 라이신씨 드링크 믹스 1스쿱 1일 4회. 표 I에는 이러한 보충제의 성분 목록이 나와 있습니다.

환자는 치료 시작과 동시에

스테로이드 크림 사용을 즉시 중단하도록 권고받았습니다.

한 달에 한 번씩 재진 예약을 잡았습니다.

Table I.

Nutritional supplements.

Supplement regimen

Nutrient amount in each tablet/scoop

Vitacor Plus-1 tablet 3 times daily
Vitamin C obtained from:
Ascorbic acid	76.7 mg
Ascorbyl palmitate	56.7 mg
Calcium ascorbate	33.3 mg
Magnesium ascorbate	33.3 mg
Vitamin E (D-α-tocopherol)	29.1 mg
Vitamin A (β carotene)	158.4 µg RE
Vitamin B1	2.3 mg
Vitamin B2	2.3 mg
Vitamin B3	15.0 mg
Vitamin B5	13.3 mg
Vitamin B6	3.3 mg
Vitamin B12	6.7 µg
Vitamin D3	1.1 µg
Folic acid	30.0 µg
Biotin	21.7 µg
L-proline	36.7 mg
L-lysine	36.7 mg
L-carnitine	11.7 mg
L-arginine	13.3 mg
L-cysteine	11.7 mg
Calcium	18.3 mg
Magnesium	12.7 mg
Potassium	6.7 mg
Zinc	2.3 mg
Manganese	433.3 µg
Copper	110.0 µg
Selenium	6.7 µg
Chromium	3.3 µg
Molybdenum	1.3 µg
Inositol	11.7 mg
Coenzyme Q10	2.3 mg
Phosphorus	5.0 mg
Pycnogenol	2.3 mg
Citrus biofl avonoids	33.3 mg
Additional natural vitamin E (β-, γ- and Δ-tocopherol)	2.6 mg
Additional natural carotenoids (α-carotene, lutein, zeaxanthin and cryptoxanthin)	22.83 µg
ProLysinC-2 tablets 3 times daily
Vitamin C obtained from:
Ascorbic acid	300 mg
L-proline	150 mg
L-lysine	300 mg
VitaCforte-2 tablets 3 times daily
Vitamin C obtained from:
Ascorbic acid	150 mg
Calcium ascorbate	150 mg
Magnesium ascorbate	150 mg
Ascorbyl palmitate	67 mg
Citric bioflavonoids	150 mg
LysinC Drink mix-1 scoop 4 times daily
Vitamin C (ascorbic acid, calcium ascorbate, magnesium ascorbate)	1,000 mg
Calcium (calcium ascorbate)	48 mg
Magnesium (magnesium ascorbate)	34 mg
L-lysine (L-lysine HCl)	1,000 mg
Citric bioflavonoids	200 mg

Open in a separate window

RE, retinol equivalents.

During the first month the patient experienced flaring of the skin condition with shedding of the dead skin. From the second month onwards, the psoriasis patches appeared thinner. Patches on the upper part of body (neck, shoulder, upper arms) appeared to heal faster than the lower parts of the body. This healing process continued and the psoriatic patches on the legs were the last to heal. At the end of 6 months the patient's psoriasis had completely disappeared (Fig. 2). The patient reported aggravation of itching and soreness in the first month, followed by gradual improvement of these symptoms over the 6 months. The patient had no complaints/side effects associated with the nutritional regimen.

첫 달 동안 

환자는 

각질이 벗겨지면서 

피부 상태가 악화되는 것을 경험했습니다. 

두 번째 달부터는 

건선 패치가 더 얇아졌습니다. 

신체 상부(목, 어깨, 팔뚝)의 건선 패치는 

하부보다 더 빨리 치유되는 것처럼 보였습니다. 

이 치유 과정은 계속되었고 

다리의 건선 패치가 가장 마지막으로 치유되었습니다. 

6개월이 지난 후 

환자의 건선은 완전히 사라졌습니다(그림 2). 

환자는 

첫달에 가려움증과 통증이 악화되었다가 

6개월 동안 이러한 증상이 점진적으로 개선되었다고 보고했습니다. 

환자는 영양 요법과 관련된 불만이나 부작용이 없었습니다.

Figure 2.

Image of the patient's back 6 months post treatment.

Go to:

Discussion

As there is no cure for psoriasis, the multiple treatment options currently available only attempt to reduce the severity of symptoms. Therapeutic approaches include natural modalities, such as sunlight, diet and stress avoidance, and pharmacological treatments, either topically applied in the form of creams or lotions, orally ingested or injected. Standard topical treatments and their side effects are as follows: Anthralin, skin irritation; calcipotriol, elevation of serum calcium; corticosteroids, skin thinning, hair follicle infections, facial redness, rosacea, a worsening of diabetes mellitus, and reduced endogenous steroid production; topical retinoids, skin reddening and irritation; and non-steroidal immunomodulators, burning sensation (5). Epidemiological studies have shown that increased intake of fresh fruits and vegetables is associated with a decreased preval‎ence of psoriasis (8,9). In his review of the literature, Wolters cites evidence of a potential benefit of dietary factors in psoriasis (9); it was reported that fasting periods, low-energy diets, vegetarian diets, and diets rich in n-3 polyunsaturated fatty acids from fish, improved the symptoms of psoriasis, as these diets were able to suppress inflammatory processes. In an Italian case-control study of 316 patients with psoriasis and 366 controls, the risk of psoriasis was found to be significantly inversely associated with the intake of carrots, tomatoes and fresh fruit, as well as with the β-carotene intake (7). The consumption of vegetables and fruits may be beneficial in psoriasis due to their high content of various antioxidants, such as carotenoids, flavonoids and vitamin C. Frei (10) reports that increasing intake of antioxidants, such as vitamin C, vitamin E, β-carotene and selenium may aid in preventing an imbalance between oxidative stress and antioxidant defence in psoriasis.

The present case had presented with severe psoriasis showed complete clearing of patches after six months on the prescribed dietary and nutritional supplement treatment. In addition to the changes made to the diet, including increased vegetable and fruit intake, the added supplements also provided support against oxidative stress (with vitamins E, C, B2 and zinc and selenium), aided normal energy metabolism (with vitamins B1, B2, B3, B5, B6, B12 and biotin, magnesium and vitamin C), maintained normal function of the immune system (with folic acid, vitamins A, D, and C, and selenium and copper); and optimized collagen formation (with vitamin C, lysine and proline). In addition, the major components of the supplements, ascorbic acid, lysine and proline, have been shown to be important in collagen integrity (11,12). Optimal collagen structure depends upon adequate supplies of ascorbic acid and the amino acids lysine and proline (11,12). In addition, lysine contributes to extracellular matrix stability as a natural inhibitor of plasmin-induced proteolysis (11). Since the human body cannot synthesize vitamin C or the amino acid lysine, they are required in the diet.

In conclusion, the nutritional dietary change and supplementation with specific nutrients resolved the patient's psoriasis in six months. In contrast to the current treatments, which are associated with various side effects that only attempt to reduce the severity of symptoms, non-toxic nutritional dietary intervention was shown to be effective in resolving the patient's psoriasis, suggesting that this treatment should approach be considered for patients with psoriasis.

건선을 완치할 수 있는 치료법은 아직 없기 때문에 

현재 사용 가능한 여러 치료 옵션은 

증상의 심각성을 줄이는 데 그치고 있습니다. 

치료 방법에는 

햇빛, 식이요법, 스트레스 회피와 같은 자연 요법과 

크림이나 로션 형태의 국소 도포, 경구 섭취 또는 주사를 통한 약물 치료가 포함됩니다. 

표준 국소 치료법과 그 부작용은 다음과 같습니다: 안트라린, 피부 자극, 칼시포트리올, 혈청 칼슘 상승, 코르티코스테로이드, 피부 얇아짐, 모낭 감염, 안면 홍조, 주사비, 당뇨병 악화, 내인성 스테로이드 생산 감소, 국소 레티노이드, 피부 발적 및 자극, 비스테로이드 면역조절제, 작열감(5). 역학 연구에 따르면 신선한 과일과 채소의 섭취 증가는 건선 유병률 감소와 관련이 있는 것으로 나타났습니다(8,9). 볼터스는 건선에 대한 식이 요인의 잠재적 이점에 대한 문헌 검토에서 금식 기간, 저에너지 식단, 채식 식단, 생선의 n-3 고도 불포화 지방산이 풍부한 식단이 염증 과정을 억제할 수 있어 건선 증상이 개선된다는 증거를 인용했습니다(9). 

건선 환자 316명과 대조군 366명을 대상으로 한 

이탈리아의 사례 대조 연구에서 

건선 위험은 당근, 토마토, 신선한 과일 섭취량과 베타카로틴 섭취량과 

유의미한 반비례 관계가 있는 것으로 밝혀졌습니다(7). 

야채와 과일의 섭취는 카로티노이드, 플라보노이드 및 비타민 C와 같은 다양한 항산화 물질의 함량이 높기 때문에 건선에 도움이 될 수 있습니다. Frei (10)는 비타민 C, 비타민 E, β- 카로틴 및 셀레늄과 같은 항산화 물질의 섭취를 늘리면 건선의 산화 스트레스와 항산화 방어 사이의 불균형을 예방하는 데 도움이 될 수 있다고보고했습니다.

본 사례의 중증 건선 환자는 

처방된 식이 및 영양 보충제 치료를 6개월간 받은 후 

건선이 완전히 사라졌습니다. 

채소 및 과일 섭취량 증가를 포함한 식단 변화와 더불어 

추가 보충제는 

산화 스트레스에 대한 지원(비타민 E, C, B2 및 아연과 셀레늄), 

정상적인 에너지 대사 지원(비타민 B1, B2, B3, B5, B6, B12 및 비오틴, 마그네슘 및 비타민 C), 

면역 체계의 정상 기능 유지(엽산, 비타민 A, D, C, 셀레늄 및 구리), 

콜라겐 형성 최적화(비타민 C, 라이신 및 프롤린)를 제공했습니다. 

또한 보충제의 주요 성분인 

아스코르브산, 라이신, 프롤린은 

콜라겐 통합에 중요한 역할을 하는 것으로 밝혀졌습니다(11,12). 

최적의 콜라겐 구조는 

아스코르브산과 아미노산인 라이신과 프롤린의 적절한 공급에 달려 있습니다(11,12). 

또한 라이신은 플라스민에 의한 단백질 분해의 천연 억제제로서 

세포 외 기질 안정성에 기여합니다(11). 

인체는 

비타민 C나 아미노산 라이신을 합성할 수 없기 때문에 

식단을 통해 섭취해야 합니다.

결론적으로, 

식단을 바꾸고 

특정 영양소를 보충한 결과 6개월 만에 환자의 건선이 해결되었습니다. 

증상의 중증도를 낮추기 위해 다양한 부작용을 동반하는 현재의 치료법과 달리, 

무독성 영양 식이 중재는 환자의 건선을 해결하는 데 효과적인 것으로 나타나 

건선 환자에게 이러한 치료법을 고려해야 함을 시사합니다.

Go to:

Note added post-publication

We received an email from a concerned reader regarding the claims made in the above paper that a patient experienced resolution of psoriatic patches on her body after having received a cocktail of nutritional supplements, while adhering to a regimen that prescribed dietary changes for a period of 6 months. Although the findings, while preliminary in nature, were potentially encouraging, the Editor agrees with the reader that the study exhibited a number of limitations. A follow-up study was not conducted, and the possibility of disease recurrence was not investigated. A follow-up study of the patient examined would also have demonstrated the effectiveness of this therapy over a long-term period. Moreover, since the present study was a case report, the findings reflect the response of an isolated patient incident. Clinical studies with a larger sample size would offer clearer insights in the efficacy of this therapy, allowing the statistical determination of clinical outcomes and benefits. Finally, the Editor also noted that the study contained an undeclared potential conflict of interest, since the nutritional supplements Vitacor Plus, ProLysinC, VitaCforte and LysinC Drink mix are sold by a company owned by Stichting Administratiekantoor Dr. Rath Holding, to whose companies group the sponsor of the study also belongs, and therefore there are commercial and financial implications associated with this case report.

위 논문에서 

한 환자가 

6개월 동안 식이 요법을 준수하면서 영양 보충제를 칵테일로 섭취한 후 

몸에 생긴 건선 패치가 사라졌다는 주장에 대해 우려하는 독자로부터 

이메일을 받았습니다. 

이 연구 결과는 예비적인 성격이 있지만 잠재적으로 고무적이지만, 편집자는 이 연구가 여러 가지 한계를 가지고 있다는 데 동의합니다. 후속 연구가 수행되지 않았으며 질병 재발 가능성에 대한 조사가 이루어지지 않았습니다. 조사 대상 환자에 대한 후속 연구를 통해 장기간에 걸친 이 치료법의 효과를 입증할 수 있었을 것입니다. 

또한, 본 연구는 사례 보고이기 때문에 

연구 결과는 고립된 환자 사례의 반응을 반영합니다. 

표본 규모가 더 큰 임상 연구에서는 이 치료법의 효과에 대한 보다 명확한 통찰력을 제공하여 임상 결과와 이점을 통계적으로 결정할 수 있을 것입니다. 

마지막으로, 

편집자는 이 연구에 신고되지 않은 잠재적 이해 상충이 포함되어 있다는 점에 주목했습니다. 영양 보충제인 Vitacor Plus, ProLysinC, VitaCforte 및 LysinC 음료 믹스는 이 연구의 후원자가 속한 회사 그룹인 Stichting Administratiekantoor Dr. Rath Holding이 소유한 회사에서 판매하며, 따라서 이 사례 보고서와 관련된 상업 및 재정 관련 영향이 있기 때문입니다.

Go to:

Funding

This study was funded by the Dr. Rath Health Foundation (Santa Clara, CA, USA), a non-profit organization.

Go to:

Competing interests

Note that the nutritional supplements described in this case report were manufactured for Dr. Rath International, Inc., owned by Dr. Rath Holding. Dr Rath is one of the contributing authors.

Go to:

References

1. Feldman SR. A quantitative definition of severe psoriasis for use in clinical trials. J Dermatolog Treat. 2004;15:27–29. doi: 10.1080/09546630310019382. [PubMed] [CrossRef] [Google Scholar]

2. Zachariae R, Zachariae H, Blomqvist K, Davidsson S, Molin L, Mørk C, Sigurgeirsson B. Self-reported stress reactivity and psoriasis related stress of Nordic psoriasis sufferers. J Eur Acad Dermatol Venereol. 2004;18:27–36. doi: 10.1111/j.1468-3083.2004.00721.x. [PubMed] [CrossRef] [Google Scholar]

3. Christophers E. Psoriasis-epidemiology and clinical spectrum. Clin Exp Dermatol. 2001;26:314–20. doi: 10.1046/j.1365-2230.2001.00832.x. [PubMed] [CrossRef] [Google Scholar]

4. Naldi L, Svensson A, Diepgen T, Elsner P, Grob JJ, Coenraads PJ, Bavinck JN, Williams H. European Dermato-Epidemiology Network: Randomized clinical trials for psoriasis 1977–2000: The EDEN survey. J Invest Dermatol. 2003;120:738–41. doi: 10.1046/j.1523-1747.2003.12145.x. [PubMed] [CrossRef] [Google Scholar]

5. Brown AC, Hairfield M, Richards DG, McMillin DL, Mein EA, Nelson CD. Medical nutrition therapy as a potential complementary treatment for psoriasis - five case reports. Altern Med Rev. 2004;9:297–307. [PubMed] [Google Scholar]

6. Naldi L, Parazzini F, Peli L, Chatenoud L, Cainelli T. Dietary factors and the risk of psoriasis. Results of an Italian case-control study. Br J Dermatol. 1996;134:101–106. doi: 10.1046/j.1365-2133.1996.d01-734.x. [PubMed] [CrossRef] [Google Scholar]

7. Kragballe K, Fogh K. A low-fat diet supplemented with dietary fish oil (Max-EPA) results in improvement of psoriasis and in formation of leukotriene B5. Acta Derm Venereol. 1989;69:23–28. [PubMed] [Google Scholar]

8. Kavli G, Forde OH, Arnesen E, Stenvold SE. Psoriasis: familial predisposition and environmental factors. Br Med J (Clin Res Ed) 1985;291:999–1000. doi: 10.1136/bmj.291.6501.999. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

9. Wolters M. Diet and psoriasis: experimental data and clinical evidence. Br J Dermatol. 2005;153:706–714. doi: 10.1111/j.1365-2133.2005.06781.x. [PubMed] [CrossRef] [Google Scholar]

10. Frei B. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med. 1999;222:196–204. doi: 10.1046/j.1525-1373.1999.d01-136.x. [PubMed] [CrossRef] [Google Scholar]

11. Rath M, Pauling L. Plasmin-induced proteolysis and the role of apoprotein (a), lysine and synthetic analogs. Orthomolecular Med. 1992;7:17–23. [Google Scholar]

12. Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M. Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice. Int J Oncol. 2013;42:55–64. [PMC free article] [PubMed] [Google Scholar]