치료적 맞춤운동, 비타미네, 영성 연구소

<p><span style="font-size: 11pt;">beyond reason</span><br></p><p><span style="font-size: 11pt;"><br></span></p><div class="c-article-header" style="margin: 0px 0px 40px; padding: 0px; color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Oxygen-Sans, Ubuntu, Cantarell, "Helvetica Neue", sans-serif; font-size: 18px; background-color: rgb(255, 255, 255);"><header><ul class="c-article-identifiers" data-test="article-identifier" style="margin-top: 0px; margin-right: 0px; margin-bottom: 8px; list-style: none; font-size: 1.6rem; line-height: 1.3; display: flex; flex-wrap: wrap; color: rgb(111, 111, 111); padding: 0px;"><li class="c-article-identifiers__item" style="border-right: 1px solid rgb(111, 111, 111); margin-right: 8px; padding-right: 8px; list-style: none;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Review Article</span></li><li class="c-article-identifiers__item" style="border-right: 0px; margin-right: 0px; padding-right: 0px; list-style: none;"><a href="https://www.nature.com/articles/s41573-019-0052-1#article-info" data-track="click" data-track-action="publication date" data-track-category="article body" data-track-label="link" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Published:</span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span><time datetime="2020-01-06" itemprop="datePublished"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">06 January 2020</span></time></a></li></ul><h1 class="c-article-title u-h1" data-test="article-title" data-article-title="" itemprop="name headline" style="margin: 0px 0px 16px; font-size: 3rem; padding: 0px; font-family: Harding, Lora, Palatino, Times, "Times New Roman", serif; line-height: 1.4;"><span style="font-family: Batang, 바탕, serif; font-size: 14pt; font-weight: normal; color: rgb(255, 0, 0);">NK cells for cancer immunotherapy</span></h1><ul class="c-author-list js-list-authors js-etal-collapsed" data-etal="25" data-etal-small="3" data-test="authors-list" style="margin-top: 0px; margin-bottom: 0px; font-size: 1.6rem; list-style: none; padding: 0px; width: 602px;"><li class="c-author-list__item" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-category="article body" data-track-label="link" href="https://www.nature.com/articles/s41573-019-0052-1#auth-1" class="js-no-scroll" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Noriko Shimasaki</span></a></span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">,</span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span></li><li class="c-author-list__item" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-category="article body" data-track-label="link" href="https://www.nature.com/articles/s41573-019-0052-1#auth-2" class="js-no-scroll" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Amit Jain</span></a></span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">&</span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span></li><li class="c-author-list__item" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person" style="margin-left: 0px; display: inline; padding-right: 0px;"><span itemprop="name"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-category="article body" data-track-label="link" href="https://www.nature.com/articles/s41573-019-0052-1#auth-3" data-corresp-id="c1" class="js-no-scroll" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Dario Campana</span><svg width="16" height="16" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#global-icon-email"><svg id="global-icon-email" viewBox="0 0 18 18"><path d="M1.995 2h14.01A2 2 0 0118 4.006v9.988A2 2 0 0116.005 16H1.995A2 2 0 010 13.994V4.006A2 2 0 011.995 2zM1 13.994A1 1 0 001.995 15h14.01A1 1 0 0017 13.994V4.006A1 1 0 0016.005 3H1.995A1 1 0 001 4.006zM9 11L2 7V5.557l7 4 7-4V7z" fill-rule="evenodd"></path></svg></use></svg></a></span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span></li></ul><p class="c-article-info-details" data-container-section="info" style="margin-top: 16px; margin-bottom: 8px; font-size: 1.6rem;"><a data-test="journal-link" href="https://www.nature.com/nrd" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline;"><i data-test="journal-title"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Nature Reviews Drug Discovery</span></i></a><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">(</span><span data-test="article-publication-year" style="font-family: Batang, 바탕, serif; font-size: 11pt;">2020</span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">)</span><a href="https://www.nature.com/articles/s41573-019-0052-1#citeas" class="c-article-info-details__cite-as u-hide-print" data-track="click" data-track-action="cite this article" data-track-category="article body" data-track-label="link" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline; border-left: 1px solid rgb(111, 111, 111); margin-left: 8px; padding-left: 8px;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Cite this article</span></a></p><div class="c-article-metrics-bar__wrapper u-clear-both" style="margin: 0px; padding: 0px;"><ul class="c-article-metrics-bar u-list-inline" style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; list-style: none; padding: 0px; display: flex; flex-wrap: wrap; line-height: 1.3; font-size: 1.6rem;"><li class=" c-article-metrics-bar__item" style="-webkit-box-align: baseline; align-items: baseline; border-right: 1px solid rgb(111, 111, 111); margin-right: 8px; display: inline;"><p class="c-article-metrics-bar__count" style="font-weight: 700;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">4159</span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span><span class="c-article-metrics-bar__label" style="color: rgb(98, 98, 98); font-weight: 400; margin: 0px 10px 0px 5px; font-family: Batang, 바탕, serif; font-size: 11pt;">Accesses</span></p></li><li class="c-article-metrics-bar__item" style="-webkit-box-align: baseline; align-items: baseline; border-right: 1px solid rgb(111, 111, 111); margin-right: 8px; display: inline;"><p class="c-article-metrics-bar__count" style="font-weight: 700;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">103</span><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"> </span><span class="c-article-metrics-bar__label" style="color: rgb(98, 98, 98); font-weight: 400; margin: 0px 10px 0px 5px; font-family: Batang, 바탕, serif; font-size: 11pt;">Altmetric</span></p></li><li class="c-article-metrics-bar__item" style="-webkit-box-align: baseline; align-items: baseline; border-right: 0px; margin-right: 8px; display: inline;"><p class="c-article-metrics-bar__details"><a href="https://www.nature.com/articles/s41573-019-0052-1/metrics" data-track="click" data-track-action="view metrics" data-track-category="article body" data-track-label="link" rel="nofollow" style="background-color: transparent; color: rgb(0, 102, 153); vertical-align: baseline;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Metrics</span><span class="u-visually-hidden" style="border: 0px; clip: rect(0px, 0px, 0px, 0px); height: 1px; margin: -1000px; overflow: hidden; padding: 0px; width: 1px; position: absolute !important; font-family: Batang, 바탕, serif; font-size: 11pt;">details</span></a></p></li></ul></div></header></div><div data-article-body="true" data-track-component="article body" class="c-article-body" style="margin: 0px; padding: 0px; clear: both; color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Oxygen-Sans, Ubuntu, Cantarell, "Helvetica Neue", sans-serif; font-size: 18px; background-color: rgb(255, 255, 255);"><section aria-labelledby="Abs1" lang="en"><div class="c-article-section" id="Abs1-section" style="margin: 0px; padding: 0px; font-family: Lora, Palatino, Times, "Times New Roman", serif; clear: both;"><h2 class="c-article-section__title u-h2 js-section-title js-c-reading-companion-sections-item" id="Abs1" style="font-size: 2.4rem; margin: 0px 0px 8px; padding: 0px; font-family: Harding, Lora, Palatino, Times, "Times New Roman", serif; line-height: 1.4; border-bottom: 1px solid rgb(213, 213, 213);"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;">Abstract</span></h2><div class="c-article-section__content" id="Abs1-content" style="margin: 0px 0px 40px; padding: 0px;"><p style="margin-bottom: 28px; overflow-wrap: break-word;"><span style="font-family: Batang, 바탕, serif; font-size: 11pt;"><b><span style="color: rgb(255, 0, 0);">Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers associated with oncogenic transformation. This property, which is unique among immune cells, and their capacity to enhance antibody and T cell responses support a role for NK cells as anticancer agents.</span></b> Although tumours may develop several mechanisms to resist attacks from endogenous NK cells, ex vivo activation, expansion and genetic modification of NK cells can greatly increase their antitumour activity and equip them to overcome resistance. Some of these methods have been translated into clinical-grade platforms and support clinical trials of NK cell infusions in patients with haematological malignancies or solid tumours, which have yielded encouraging results so far. The next generation of NK cell products will be engineered to enhance activating signals and proliferation, suppress inhibitory signals and promote their homing to tumours. These modifications promise to significantly increase their clinical activity. Finally, there is emerging evidence of increased NK cell-mediated tumour cell killing in the context of molecularly targeted therapies. These observations, in addition to the capacity of NK cells to magnify immune responses, suggest that NK cells are poised to become key components of multipronged therapeutic strategies for cancer.</span></p></div></div></section></div><p><br></p>