<div><span class="nowrap" id="result_sel"></span><input name="EntrezSystem2.PEntrez.PubMed.Pubmed_ResultsPanel.Pubmed_ResultsController.ResultCount" id="resultcount" type="hidden" value="1" sid="1"><input name="EntrezSystem2.PEntrez.PubMed.Pubmed_ResultsPanel.Pubmed_ResultsController.RunLastQuery" type="hidden" sid="1"></div><div class="empty" id="messagearea"></div><div class="rprt_all"><div class="rprt abstract"><div class="cit"><span role="menubar"><a title="PloS one." role="menuitem" aria-expanded="false" aria-haspopup="true" href="https://www.ncbi.nlm.nih.gov/pubmed/28973012#" abstractlink="yes" alsec="jour" alterm="PLoS One."><u><span class="highlight"><font color="#0066cc">PLoS One</font></span><font color="#0066cc">.</font></u></a></span> 2017 Oct 3;12(10):e0185778. doi: 10.1371/journal.pone.0185778. eCollection 2017.</div><h1>The relationship between drinking alcohol and esophageal, <br>gastric or colorectal cancer: A nationwide population-based<br> cohort study of South Korea.</h1><div class="auths"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Choi%20YJ%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><span class="highlight"><font color="#0066cc">Choi</font></span><font color="#0066cc"> YJ</font></u></a><sup><font size="2">1</font></sup>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Lee%20DH%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Lee DH</font></u></a><font size="2"><sup>1,</sup><sup>2</sup></font>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Han%20KD%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Han KD</font></u></a><sup><font size="2">3</font></sup>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Kim%20HS%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Kim HS</font></u></a><sup><font size="2">1</font></sup>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yoon%20H%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Yoon H</font></u></a><sup><font size="2">1</font></sup>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Shin%20CM%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Shin CM</font></u></a><sup><font size="2">1</font></sup>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Park%20YS%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Park YS</font></u></a><font size="2"><sup>1,</sup><sup>2</sup></font>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Kim%20N%5BAuthor%5D&cauthor=true&cauthor_uid=28973012"><u><font color="#0066cc">Kim N</font></u></a><font size="2"><sup>1,</sup><sup>2</sup></font>.</div><div class="afflist" style="-ms-zoom: 1;"><h3 style="-ms-zoom: 1;"><a title="Open/close author information list" class="jig-ncbitoggler ui-widget ui-ncbitoggler" id="ui-ncbitoggler-2" role="button" aria-expanded="false" href="https://www.ncbi.nlm.nih.gov/pubmed/28973012#"><u><font color="#0066cc"><span class="ui-ncbitoggler-master-text">Author information</span><span class="ui-icon ui-icon-triangle-1-e"></span></font></u></a></h3><div class="ui-helper-reset" aria-live="assertive"><dl class="ui-ncbi-toggler-slave ui-ncbitoggler ui-ncbitoggler-slave" aria-hidden="true"><dt>1 Department of Internal Medicine and Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.</dt><dt>2 Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, <br> Seoul, South Korea.</dt><dt>3 Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.</dt></dl></div></div><div class="abstr"><h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext label="BACKGROUND" nlmcategory="BACKGROUND">Epidemiologic findings of low-volume alcohol consumption in relation to gastrointestinal cancers including gastric <br>cancer are inconsistent.</abstracttext></p><h4>METHODS: </h4><p><abstracttext label="METHODS" nlmcategory="METHODS">The association between alcohol intake and esophageal, gastric and colorectal cancer risk was examined in a <br>population-based prospective cohort of 23,323,730 adults in Korea who had undergone a biennial eval‎uation provided by <br>the National Health Insurance Corporation between the years 2009 and 2012. <br>After median 5.4 years of follow-up, 9,171 esophageal, 135,382 gastric and 154,970 colorectal cancer cases were identified. <br>Cox regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI).</abstracttext></p><h4>RESULTS: </h4><p><abstracttext label="RESULTS" nlmcategory="RESULTS">Light drinking as well as moderate to heavy alcohol consumption significantly increased the risks of the three gastrointestinal<br> cancers (HR 1.51; 95% CI, 1.43-1.60; HR 1.08; 95% CI, 1.06-1.09; HR 1.12; 95% CI, 1.11-1.14) compared with non-drinkers <br>after adjusting for age, sex, smoking, exercise, income, body mass index, and diabetes. <br>The synergistically increased cancer risk between excessive amount of alcohol consumption and currently smoking or <br>underweight individuals was observed only in the esophageal cancers.</abstracttext></p><h4>CONCLUSIONS: </h4><p><abstracttext label="CONCLUSIONS" nlmcategory="CONCLUSIONS">Light drinking including even one alcoholic drink a day is associated with increased risks of esophageal, gastric and <br>colorectal cancer.</abstracttext></p></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMID: 28973012</dt> <dt>DOI: <a href="https://doi.org/10.1371/journal.pone.0185778" ref="aid_type=doi"><u><font color="#0066cc">10.1371/journal.pone.0185778</font></u></a><div class="resc status"><span class="status_icon"></span><span class="status_icon"><hr style="border-width: 1px 0px 0px; 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The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South Korea.
