Re:Re:A systematic reconsideration on proteases

<p><span style="font-size: 14.6667px;">beyond reason</span></p><p><span style="font-size: 14.6667px;"><br></span></p><h1 id="screen-reader-main-title" class="Head u-font-serif u-h2 u-margin-s-ver" style="box-sizing: border-box; margin-right: 0px; margin-left: 0px; padding: 0px; color: rgb(80, 80, 80); word-break: break-word; margin-top: 16px !important; margin-bottom: 16px !important; font-size: 1.5rem !important; font-weight: 400 !important; line-height: 1.333 !important; font-family: NexusSerif, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif !important;"><div class="article-dochead" style="box-sizing: border-box; margin: 0px; padding: 0px; line-height: 22px; color: rgb(115, 115, 115); font-size: 13px;"><span style="box-sizing: border-box; margin: 0px; padding: 0px;">Review</span></div><span class="title-text" style="box-sizing: border-box; margin: 0px; padding: 0px;">A systematic reconsideration on proteases</span></h1><div class="Banner" id="banner" style="box-sizing: border-box; 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color: rgb(12, 125, 187); word-break: break-word;"><span class="content" style="box-sizing: border-box; margin: 0px; padding: 0px;"><span class="text given-name" style="box-sizing: border-box; margin: 0px; padding: 0px;">Poorani</span><span class="text surname" style="box-sizing: border-box; margin: 0px; padding: 0px;">Gurumallesh</span></span></a><a class="author size-m workspace-trigger" name="bau0010" href="https://www.sciencedirect.com/science/article/pii/S0141813018351997#!" style="box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; color: rgb(12, 125, 187); word-break: break-word;"><span class="content" style="box-sizing: border-box; margin: 0px; padding: 0px;"><span class="text given-name" style="box-sizing: border-box; margin: 0px; padding: 0px;">Kamalini</span><span class="text surname" style="box-sizing: border-box; margin: 0px; padding: 0px;">Alagu</span></span></a><a class="author size-m workspace-trigger" name="bau0015" href="https://www.sciencedirect.com/science/article/pii/S0141813018351997#!" style="box-sizing: border-box; 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margin: 0px; padding: 0px; font-family: NexusSerif, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif !important; font-size: 18px; line-height: 26px; color: rgb(46, 46, 46); font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"><div class="abstract author" id="ab0005" lang="en" style="box-sizing: border-box; margin: 0px 0px 8px; padding: 0px;"><h2 class="section-title u-h3 u-margin-l-top u-margin-xs-bottom" style="box-sizing: border-box; margin-top: 32px !important; margin-right: 0px; margin-bottom: 8px !important; margin-left: 0px; padding: 0px; font-weight: 400 !important; color: rgb(80, 80, 80); font-size: 1.2rem !important; line-height: 1.333 !important;">Abstract</h2><div id="as0005" style="box-sizing: border-box; margin: 0px; padding: 0px;"><p id="sp0075" style="box-sizing: border-box; margin: 0px 0px 16px; padding: 0px;"><span style="box-sizing: border-box; margin: 0px; padding: 0px;"><a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/protease" title="Learn more about Protease from ScienceDirect's AI-generated Topic Pages" style="box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(12, 125, 187); word-break: break-word;">Proteases</a><span style="box-sizing: border-box; margin: 0px; padding: 0px;"><span> </span>are a group of large complex enzyme molecules that perform highly focused<span> </span><a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/protein-catabolism" title="Learn more about Protein Catabolism from ScienceDirect's AI-generated Topic Pages" style="box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(12, 125, 187); word-break: break-word;">proteolysis</a><span> </span>functions. A vast quantity of the protease enzymes is predominantly sourced from microbial<span> </span></span></span><a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/fermentation" title="Learn more about Fermentation from ScienceDirect's AI-generated Topic Pages" style="box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(12, 125, 187); word-break: break-word;">fermentation</a><span style="box-sizing: border-box; margin: 0px; padding: 0px;"><span> </span>process, although proteases tend to natively present in plant, animals and humans. Proteases possess a pervasive importance in medical and pharmaceutical sector, because of its enriched specificity towards biomolecules. They are also actively encompassed in regulating certain physiological pathways. A distinct territory of human disorders is treated by substrate specific proteases. Enormous numbers of<span> </span><a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/enzymatic-activity" title="Learn more about Enzymatic Activity from ScienceDirect's AI-generated Topic Pages" style="box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; text-decoration: none; color: rgb(12, 125, 187); word-break: break-word;">catalytic activities</a><span> </span>in habitual metabolism process of a living organism are protease dependent. Pilot scale researches and product development in industrial biotechnology sectors are wholly based on any one of the protease enzymes. The applications of the protease enzymes and its economic benefits of being an eco-friendly material are far-reaching. This review presents a brief overview on the classification and sources of various types of proteases. We describe the essential evidences of role of protease in different sectors. The proteases could be a potential relieves to harmful synthetic chemicals in distinctive industrial processes and thus gains global perception.</span></p></div></div></div><p><br></p>