Location: Hades Palace Closest Portal: Hades Palace Noteable Loot: Access to almost all the loot in the game with his loot table
Hades is the final boss of the Titan Quest: Immortal Throne expansion pack and is one of the best bosses of the game to farm. Since Hades has just as good (if not better) of a loot table than Typhon and he is significantly easier to farm than Typhon most people prefer this boss instead.
You can find Hades inside of Hades Palace at the end of Act 4. The fastest way here is to take the Hades Palace Portal and then run through his entire palace; make sure you grab the Rebirth Shrine in the Prison of Souls as that is the closest one to Hades.
When farming Hades he has a chance of dropping The Overlord item which is use for opening the gate that leads to the Secret Passage area. For more information about this zone check out either my Secret Passage Farming Location or How to Access The Secret Passage. Both guides will have the information you're after.
Hades using his Death Vortex Ability during Phase 2.
As for the boss fight with Hades I have two pieces of information that will help you out. The first of which is - cap your Vitality Resistance at 80%. Hades overwhelmingly deals Vitality damage with his attacks as well as a small amount of Physical damage too. Having capped Vitality Resistance will help you out significantly.
My second big tip for fighting Hades is to learn what the animation for the Shadow Star ability looks like and avoid it at all costs. This ability can shotgun you can have every single projectile hit you at once which will definitely instantly kill you. Below is a list of all the abilities that you should expect Hades to use during this fight as well as a little bit of information about each one.
(Phase 1 and 3) Shadow Star: This is Hades most deadly ability and it comes with a very distinct animation. Hades will slowly lift his right hand and he will lob a red ball at you. When this ball makes contact with the ground it will split into 8 Shadow Bolt projectiles, all of which can damage your character. If this attack hits you then you will take full damage from ALL of the projectiles - which will one shot you. During Phase 3 this ability will change slightly and the Shadow Stars will fly in random directions instead of their original predictable trajectory.
(Phase 1 and 2) Sickle Sweep: Hades melee attack, he'll do a sweep with his Sickle that deals Physical and Vitality damage to anyone hit by it.
(All Phases) Shadow Bolt: Looks similar to Shadow Star but it flies through the air much faster and is smaller. There is also a different cast animation for this ability. Learn the difference between this ability and Shadow Star if you wish to survive.
(Phase 2) Shadow Balls: I'm bouncing off the walls again Woah-oh. Hades tosses a few Shadow Balls that bounce around the room erratically. Hard to avoid so Vitality Resistance helps to eat the damage.
(Phase 2) Death Vortex: Another one of Hades very deadly abilities. He will summon a vortex on the ground that resembles a small whirlpool and it will follow you around very slowly for 12 seconds. The vortex itself deals Vitality and Physical damage and a lot of it at that.
(Phase 3) Expanding Ring: A circle of Spirits will expand from Hades position; anyone hit by it will take Vitality and Physical damage.
(Phase 3) Uber Shadow Bolt: Like the Shadow Bolt ability from previous phases just much more powerful. It will deals "Reduction to Enemy's Health" damage as well as high Vitality damage.