<p> </p><p> </p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564526/#" target="_top" class="ke-link">Cells.</a> 2020 Sep; 9(9): 2073.</p><p><span>Published online 2020 Sep 10. </span><span>doi: <a href="https://doi.org/10.3390%2Fcells9092073" target="_blank" class="ke-link">10.3390/cells9092073</a></span></p><p> </p><p>Osteoblast-Osteoclast Communication and Bone Homeostasis</p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/3e07ca36cb32d034b9c618f86501b0f9b06369cf" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/3e07ca36cb32d034b9c618f86501b0f9b06369cf" data-origin-width="774" data-origin-height="705"></div><p> </p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/975c8cb3f110f9ddadab26614e22bb198f0227a9" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/975c8cb3f110f9ddadab26614e22bb198f0227a9" data-origin-width="787" data-origin-height="472"><div class="figcaption">Key mediators of osteoblast-osteoclast interaction. Osteoblast-osteoclast communications are essential for fine-tuning of bone remodeling during bone homeostasis. (1) Osteoblasts and osteoclasts have direct contacts through the interactions between EFNB2-EPHB4, FAS-FASL and NRP1-SEMA3A to regulate cell proliferation, differentiation, and survival. (2) Osteoclast-mediated bone resorption releases TGF-β and IGF-1 from bone matrix to induce osteoblast-mediated bone formation. (3) Osteoblasts secrete M-CSF, RANKL, WNT5A that promote osteoclast formation and development and OPG and WNT16 that inhibit osteoclast activity. Conversely, osteoclasts secrete S1P, CTHRC1 and C3 that promote osteoblast differentiation and SEMA4D that suppresses osteoblasts differentiation.</div></div><p> </p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/74f4723851639702bde6f161777f6175df1ebda2" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/74f4723851639702bde6f161777f6175df1ebda2" data-origin-width="1280" data-origin-height="880"><div class="figcaption">FIGURE 1.  Representation of bone structure. Two types of osseous tissue can be identified: compact bone and trabecular bone. Bone tissue is subjected to bone remodeling, a life-dominant process that plays an important role in bone mass balance and mineral homeostasis. During bone remodeling osteoclasts, derived from hematopoietic stem cells, resorb old, or damaged bone. Subsequently, osteoblasts, derived from mesenchymal stem cells, are recruited to the damaged area in order to replace bone removed by osteoclasts. Instead, osteocytes derived from osteoblasts suspend their activity when buried in the bone matrix.</div></div><p> </p><p> </p><ul style="list-style-type: disc;" data-ke-list-type="disc"><li>Review</li><li><span style="color: #cc4b14;">Open Access</span></li><li><a href="https://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0995-x#article-info" target="_top" class="ke-link">Published: 26 September 2018</a></li></ul><p>Osteogenesis and aging: lessons from mesenchymal stem cells</p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/9a7cb0dad283a712f0e2a7a3591492f0fdd92010" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/9a7cb0dad283a712f0e2a7a3591492f0fdd92010" data-origin-width="685" data-origin-height="460"></div><p> </p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/4e01b01aa566415203d9299bcd3f81b20dec80a1" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/4e01b01aa566415203d9299bcd3f81b20dec80a1" data-origin-width="685" data-origin-height="613"><div class="figcaption">Age-related alterations of a number of cell-intrinsic factors can shift MSC differentiation to adipogenesis. Cell-extrinsic factors such as young paracrine factors and ECM, rapamycin, and resveratrol have been proven to restore osteogenic potential of aged MSCs through modulation of these impaired cell-intrinsic factors</div></div><p> </p><p>The Role of Zinc in Bone Mesenchymal Stem Cell Differentiation</p><p> </p><p><span><span>Published Online:</span><span>4 Apr 2022</span></span></p><p> </p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/9bcaf1ead079448eee36d967bcd573467600fbea" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/9bcaf1ead079448eee36d967bcd573467600fbea" data-origin-width="1280" data-origin-height="464"></div><p> </p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/f92c01c2011fc1c20c0fc0469fd9bfcf7a1ddb79" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/f92c01c2011fc1c20c0fc0469fd9bfcf7a1ddb79" data-origin-width="1280" data-origin-height="884"></div><p> </p><p>Senescence of mesenchymal stem cells (Review)</p><ul style="list-style-type: disc;" data-ke-list-type="disc"><li><span>Authors:</span> <ul style="list-style-type: disc;" data-ke-list-type="disc"></ul></li><li><span>Published online on:</span> <span>March 9, 2017</span> </li></ul><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/309e22095e8a685702245d7fc72c55bea52483ce" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/309e22095e8a685702245d7fc72c55bea52483ce" data-origin-width="1280" data-origin-height="1303"></div><p> </p><p><a href="https://www.sciencedirect.com/journal/mechanisms-of-ageing-and-development/vol/198/suppl/C" target="_top" class="ke-link">Volume 198</a>, September 2021, 111539</p><p> </p><p><span>Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints</span></p><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/z4ZG/947b83cafa5c18b3bf495b58b42373edf1a0a6ac" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/z4ZG/947b83cafa5c18b3bf495b58b42373edf1a0a6ac" data-origin-width="1280" data-origin-height="1010"></div>
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