부천재활병원 당뇨약이 뇌졸중을 줄인다??? 뇌졸중의 원인인 당뇨는 조절되어야 합니다.

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class="se_textView"><p class="se_textarea"><span style="color: rgb(241, 47, 34);"><b>당뇨환자 전세계 </b></span><span style="color: rgb(241, 47, 34);"><b>4</b></span><span style="color: rgb(241, 47, 34);"><b>억명 </b></span><span style="color: black;">이라는 숫자는 우리들을 무척 놀라게 하는 수치입니다</span><span style="color: black;">. </span><span style="color: black;">우리나라도 당뇨환자가 급증하고 있어 앞으로 사회적 문제가 될 가능성이 높습니다</span><span style="color: black;">. </span><span style="color: black;">노년이 편안하여야 하지만 병마에 시달려 고통받는 시간이 많아지면 삶의 질의 저하가 불 보듯 뻔하기 때문입니다</span><span style="color: black;">. 2016</span><span style="color: black;">년의 당뇨병 통계를 참조해보면 </span><span style="color: black;">30</span><span style="color: black;">대 이상 성인 </span><span style="color: black;">13.7%</span><span style="color: black;">인 </span><span style="color: black;">470</span><span style="color: black;">만명이 당뇨병 환자이고 </span><span style="color: black;">65</span><span style="color: black;">세 이상 </span><span style="color: black;"></span><span style="color: rgb(241, 47, 34);"><b>노인분들의 </b></span><span style="color: rgb(241, 47, 34);"><b>1/3</b></span><span style="color: rgb(241, 47, 34);"><b>이 당뇨병</b></span><span style="color: black;">을 앓고 계신 것으로 집계되고 있습니다</span><span style="color: black;">. </span><span style="color: black;">한동안 당뇨 치료제 중</span><br><span style="color: black;">2007</span><span style="color: black;">년 </span><span style="color: black;">FDA</span><span style="color: black;">가 심근경색증</span><span style="color: black;">(MI) </span><span style="color: black;">위험 증가로 </span><span style="color: black;"></span><span style="color: rgb(0, 175, 239);"><b>로시글리타존(</b><span style="color: rgb(0, 175, 239);"><b>DPP-4 </b></span><span style="color: rgb(0, 175, 239);"><b>억제제)</b></span><b>의</b></span><span style="color: rgb(0, 175, 239);"><b> 사용 중지</b></span><span style="color: black;">를 권고한 </span><span style="color: black;">이후부터 당뇨약을 </span><span style="color: black;">뇌심혈관</span><span style="color: black;"> 영향 까지 고려해서 사용해야 되는 경향으로 바뀌게 되었습니다</span><span style="color: black;">. </span><span style="color: black;">당뇨병의 증가세가 뚜렷한 가운데 당뇨 치료제 중 </span><span style="color: black;"></span><span style="color: rgb(241, 47, 34);"><b>SGLT-2(sodium </b></span><span style="color: rgb(241, 47, 34);"><b>glucose </b></span><span style="color: rgb(241, 47, 34);"><b>contrasporter-2) </b></span><span style="color: rgb(241, 47, 34);"><b>억제제</b></span><span style="color: rgb(241, 47, 34);"><b> </b></span><span style="color: black;">라는 약물사용이 </span><span style="color: rgb(0, 175, 239);"><b>뇌와 심혈관 질환</b></span><span style="color: rgb(0, 175, 239);"><b>, </b></span><span style="color: rgb(0, 175, 239);"><b>신장보호효과</b></span><span style="color: rgb(0, 175, 239);"><b>, </b></span><span style="color: rgb(0, 175, 239);"><b>체중증가 감소에 상당한 도움</b></span><span style="color: black;">이 된다는 결과들을 잇따라 발표하고 있습니다</span><span style="color: black;">. </span><span style="color: black;">그리고 현재 </span><span style="color: black;">SGLT-2 </span><span style="color: black;">억제제를 미국에서도 적극 권장하는 추세여서 관심을 기울여 보는 것이 좋을 듯 합니다</span><span style="color: black;">. </span><span style="color: black;">SGLT-2 </span><span style="color: black;">억제제는 신장에서 포도당의 배출을 촉진함으로써 혈당을 강하시키는 남다른 기전이 있습니다</span><span style="color: black;">. </span><span style="color: black;">혈당이 </span><span style="color: black;">200mg/dL </span><span style="color: black;">이상이 되면 소변으로 당이 배출되는데 </span><span style="color: black;">SGLT-2 </span><span style="color: black;">억제제는 </span><span style="color: black;">180mg/dL</span><span style="color: black;">이하로 혈당을 저하시켜주고 소변으로 당을 내보내기 때문에 체중 감소 효과도 동시에 가지고 있습니다</span><span style="color: black;">. </span><span style="color: black;">가장 중요한 기전중의 하나는 혈당이 높을 때만 소변을 통해 당을 배출하기에 </span><span style="color: black;">저혈당의</span><span style="color: black;"> 위험이 낮습니다</span><span style="color: black;">. </span><span style="color: black;">여기에 더하여 소변량 증가로 인한 고혈압 강하 효과도 있습니다</span><span style="color: black;">. </span><span style="color: black;">이러한 이유들로 최근에 </span><span style="color: black;">뇌심혈관</span><span style="color: black;"> 질환 연구들이 진행되어 긍정적인 결과들을 발표하고 있고 임상적 적용도 이루어지고 있습니다</span><span style="color: black;">. </span><span style="color: black;">그 결과들을 간략하게 알아보고 정리해 보겠습니다</span><span style="color: black;">.</span><span style="color: black;"> <br></span><span style="color: black;"></span><br><span style="color: rgb(0, 175, 239);"><b>경구 혈당 </b></span><span style="color: rgb(0, 175, 239);"><b>강하제</b></span><span style="color: rgb(0, 175, 239);"><b> 종류는</b></span><span style="color: rgb(0, 175, 239);"><b>?</b></span><br><span style="color: black;">◈ </span><span style="color: black;">설폰요소제</span><span style="color: black;">(Sulfonylureas) </span><span style="color: black;">◈ </span><span style="color: black;">메글리티나이드계</span><span style="color: black;">(Meglitinides)</span><br><span style="color: black;">◈ </span><span style="color: black;">비구아나이드계</span><span style="color: black;">(Biguanides)</span><span style="color: black;"> ◈ </span><span style="color: black;">치아졸리딘디온계</span><span style="color: black;">(Thiazolidinediones=TZD)</span><br><span style="color: black;">◈ </span><span style="color: black;">알파글루코시다아제</span><span style="color: black;"> </span><span style="color: black;">억제제</span><span style="color: black;">(α-glucosidase inhibitors)</span><br><span style="color: black;">◈ </span><span style="color: black;">DPP-4 </span><span style="color: black;">억제제</span><span style="color: black;">(dipeptidyl-peptidase inhibitors)</span><span style="color: black;"> </span><br><span style="color: black;">◈ </span><span style="color: black;"></span><span style="color: red;"><b>SGLT-2 </b></span><span style="color: red;"><b>억제제</b></span><span style="color: red;"><b>(sodium-glucose cotransporter 2 inhibitors</b></span><span style="color: red;"><b>)</b></span><span style="color: black;"></span><span style="color: black;">: </span><span style="color: black;">국내에서 포시가</span><span style="color: black;">, </span><span style="color: black;">자디앙</span><span style="color: black;">, </span><span style="color: black;">슈디앙</span><span style="color: black;">, </span><span style="color: black;">자보카나</span><span style="color: black;"> 등이<span> </span>사용되고 있습니다</span><span style="color: black;">.<br></span> <span style="color: black;">◈ 복합제제<br></span><span style="color: black;"><span style="color: black;"><br></span><span style="color: black;">논문들 발표에서 사용되는 연구명은 대부분 대문자로 줄여서 쓰기 때문에 일반인들은 알기 쉽지 않습니다</span><span style="color: black;">. </span><span style="color: black;">연구들이 많고 혼란을 피하기 위해 사용하는 것이어서 아래에 사용할 단어들은 참고로 알고 계시면 될 것 같습니다</span><span style="color: black;">.</span><br><span style="color: black;">EMPA-REG OUTCOME </span><span style="color: black;">연구</span><span style="color: black;">,</span><span style="color: black;"> </span><span style="color: black;">CANVAS, </span><span style="color: black;">RCT(Randomized Clinical Trials)</span><span style="color: black;">연구인 </span><span style="color: black;">DECLARE </span><span style="color: black;">,</span><span style="color: black;"> CVD-REAL </span><span style="color: black;">1,</span><span style="color: black;"> CVD-REAL </span><span style="color: black;">2</span><br><span style="color: black;">이러한 연구들 에서 </span><span style="color: black;">SGLT-2 </span><span style="color: black;">효과는 제품마다 다 일치하지는 않았지만 전체적인 이득은 다음과 같습니다</span><span style="color: black;">. </span> <span style="color: black;">SGLT-2</span><span style="color: black;">억제제는 다른 경구용 혈당강하제 대비 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>1.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">제 </span><span style="color: black;">2</span><span style="color: black;">형 당뇨병 환자의 모든 원인에 의한 사망 위험을 </span><span style="color: black;">49%, </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>2.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">심부전으로 </span><span style="color: black;">인한 입원 위험을 </span><span style="color: black;">36%, </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>3.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">모든 </span><span style="color: black;">원인에 의한 사망 또는 심부전으로 인한 입원 위험을 </span><span style="color: black;">40%, </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>4.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">심근경색 </span><span style="color: black;">위험을 </span><span style="color: black;">19%, </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>5.</b></span></span></span><span style="color: black;"><span style="color: rgb(91, 155, 213);"></span><span style="color: black;">뇌졸중 </span><span style="color: black;">위험을 </span><span style="color: black;">32% </span><span style="color: black;">낮았습니다</span><span style="color: black;">.</span><span style="color: black;"> </span><br><span style="color: black;">분당서울대병원 내분비내과 임수 </span><span style="color: black;">교수는 부가적 설명에서 </span><span style="color: black;">SGLT-2 </span><span style="color: black;">억제제가 </span><span style="color: black;">임상적 </span><span style="color: black;">시사하는 것은 </span><br><span style="color: rgb(91, 155, 213);"></span></span><span style="color: black;"><span style="color: rgb(91, 155, 213);"><b>1.</b></span><span style="color: black;"></span></span><span style="color: black;"><span style="color: black;">삼투성</span><span style="color: black;"> </span><span style="color: black;">이뇨 작용으로 심부전에 혜택 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>2.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">체중 </span><span style="color: black;">감소 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>3.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">비알콜성</span><span style="color: black;"> </span><span style="color: black;">지방간 개선 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>4.</b></span></span></span><span style="color: black;"><span style="color: rgb(91, 155, 213);"></span><span style="color: black;">케톤체</span><span style="color: black;"> </span><span style="color: black;">생성 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>5.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">글루카곤</span><span style="color: black;"> </span><span style="color: black;">증가 </span><span style="color: rgb(91, 155, 213);">5.</span><span style="color: black;">트리글리세이드</span><span style="color: black;">(</span><span style="color: black;">콜레스테롤과 함께 동맥 경화 일으키는 혈중 지방 성분</span><span style="color: black;">) </span><span style="color: black;">수치 </span><span style="color: black;">감소 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>6.</b></span></span></span><span style="color: black;"><span style="color: rgb(91, 155, 213);"></span><span style="color: black;">혈압 </span><span style="color: black;">감소 </span><span style="color: rgb(91, 155, 213);"></span></span><span style="color: black;"><b>7.</b></span><span style="color: black;"><span style="color: rgb(91, 155, 213);"></span><span style="color: black;">단백뇨 </span><span style="color: black;">감소 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>8.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">요산 </span><span style="color: black;">감소 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>9.</b></span></span></span><span style="color: black;"><span style="color: rgb(91, 155, 213);"></span><span style="color: black;">항 </span><span style="color: black;">죽상경화증</span><span style="color: black;"> 효과 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>10.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">신장애</span><span style="color: black;"> </span><span style="color: black;">환자에서의 사용 가능 </span></span><span style="color: black;"><span style="color: black;"><span style="color: black;"></span><span style="color: rgb(91, 155, 213);"><b>11.</b></span><span style="color: black;"></span></span></span><span style="color: black;"><span style="color: black;">안전성 등이라고 언급했습니다</span><span style="color: black;">.</span><span style="color: black;"> </span> <span style="color: black;">하지만 모든 약물은 부작용이 있기 마련입니다</span><span style="color: black;">. </span><span style="color: black;">생식기 감염</span><span style="color: black;">, </span><span style="color: black;">급성 </span><span style="color: black;">신부전</span><span style="color: black;">(</span><span style="color: black;">카나글리플로진과</span><span style="color: black;"> </span><span style="color: black;">다파글리플로진</span><span style="color: black;">), </span><span style="color: black;">하지절단 위험</span><span style="color: black;">(</span><span style="color: black;">카나글리플로진</span><span style="color: black;">)</span><span style="color: black;"> </span><span style="color: black;">등 안전성 이슈가 제기된 바 </span><span style="color: black;">있습니다</span><span style="color: black;">. </span><span style="color: black;">카나글리플로진은</span><span style="color: black;"> </span><span style="color: black;">CANVAS </span><span style="color: black;">연구에서 </span><span style="color: black;">1.97</span><span style="color: black;">배 높은 하지절단 위험이 보고됐는데</span><span style="color: black;">, </span><span style="color: black;">이는 다른 </span><span style="color: black;">SGLT-2 </span><span style="color: black;">억제제에서는 확인되지 </span><span style="color: black;">않았고 계속 추적 연구 중 입니다</span><span style="color: black;">. </span><br><span style="color: black;">결론</span><span style="color: black;">: </span><span style="color: black;">SGLT-2 </span><span style="color: black;">억제제는 </span></span><span style="color: rgb(241, 47, 34);"><span style="color: black;"><span style="color: rgb(241, 47, 34);"><b>심근경색 </b></span><span style="color: rgb(241, 47, 34);"><b>19%, </b></span><span style="color: rgb(241, 47, 34);"><b>뇌졸중 </b></span><span style="color: rgb(241, 47, 34);"><b>32% </b></span><span style="color: rgb(241, 47, 34);"><b>정도의 위험을 감소 </b></span></span></span><span style="color: black;"><span style="color: black;">시켰습니다</span><span style="color: black;">.<span style="color: black;">SGLT-2 </span><span style="color: black;">억제제</span> </span><span style="color: black;">를 당뇨약으로</span><span style="color: black;"> </span><span style="color: black;">선택시</span><span style="color: black;"> </span></span><span style="color: rgb(241, 47, 34);"><span style="color: rgb(241, 47, 34);"><b>콩팥이 나빠도 사용할 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-khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" unselectable="on"><u><font color="#0066cc"><img width="256" height="256" style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 256px; height: 256px; display: block; position: absolute; z-index: 0; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fsimg.pstatic.net%2Fonetile%2Fget%2F202%2F0%2F0%2F12%2F3306%2F2937%2Fbl_vc_bg%2Fol_vc_an" unselectable="on"></font></u></div><div style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 42px; top: -235px; width: 256px; height: 256px; position: absolute; z-index: 0; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; transform: translateZ(0px); user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" unselectable="on"><u><font color="#0066cc"><img width="256" height="256" style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 256px; height: 256px; display: block; position: absolute; z-index: 0; min-height: 0px 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-khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" unselectable="on"><u><font color="#0066cc"><img width="256" height="256" style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 256px; height: 256px; display: block; position: absolute; z-index: 0; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fsimg.pstatic.net%2Fonetile%2Fget%2F202%2F0%2F0%2F12%2F3307%2F2938%2Fbl_vc_bg%2Fol_vc_an" unselectable="on"></font></u></div><div style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: -214px; top: 21px; width: 256px; height: 256px; position: absolute; z-index: 0; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; transform: translateZ(0px); user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" unselectable="on"><u><font color="#0066cc"><img width="256" height="256" style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 256px; height: 256px; display: block; position: absolute; z-index: 0; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fsimg.pstatic.net%2Fonetile%2Fget%2F202%2F0%2F0%2F12%2F3303%2F2938%2Fbl_vc_bg%2Fol_vc_an" unselectable="on"></font></u></div><div style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 810px; top: 277px; width: 256px; height: 256px; position: absolute; z-index: 0; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; transform: translateZ(0px); user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" unselectable="on"><u><font color="#0066cc"><img width="256" height="256" style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 256px; height: 256px; display: block; position: absolute; z-index: 0; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fsimg.pstatic.net%2Fonetile%2Fget%2F202%2F0%2F0%2F12%2F3307%2F2937%2Fbl_vc_bg%2Fol_vc_an" unselectable="on"></font></u></div><div style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: -214px; top: -235px; width: 256px; height: 256px; position: absolute; z-index: 0; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; transform: translateZ(0px); user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" unselectable="on"><u><font color="#0066cc"><img width="256" height="256" style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 256px; height: 256px; display: block; position: absolute; z-index: 0; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important; box-sizing: content-box !important; opacity: 1; -ms-user-select: none; user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fsimg.pstatic.net%2Fonetile%2Fget%2F202%2F0%2F0%2F12%2F3303%2F2939%2Fbl_vc_bg%2Fol_vc_an" unselectable="on"></font></u></div></div></div><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 0px; top: 0px; width: 100%; height: 0px; overflow: visible; display: block; position: absolute; z-index: 100;"><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 0px; top: 0px; width: 100%; height: 0px; overflow: visible; display: block; position: absolute; z-index: 101;"></div><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 0px; top: 0px; width: 100%; height: 0px; overflow: visible; display: block; position: absolute; z-index: 103;"><div title="" style="left: 336px; top: 128px; width: 22px; height: 35px; overflow: hidden; position: absolute; cursor: inherit; box-sizing: content-box !important;"><u><font color="#0066cc"><img style="margin: 0px; padding: 0px; border: 0px solid transparent; border-image: none; left: 0px; top: 0px; width: 22px; height: 35px; display: block; position: absolute; cursor: pointer; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important; box-sizing: content-box !important; -ms-user-select: none; user-select: none; -webkit-user-select: none; -moz-user-select: none; -webkit-touch-callout: none; -khtml-user-select: none; -webkit-user-drag: none; -khtml-user-drag: none; -moz-user-drag: none; -o-user-drag: none; user-drag: none;" draggable="false" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fssl.pstatic.net%2Fstatic%2Fmaps%2Fv3%2Fpin_default.png" unselectable="on"></font></u></div></div><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 0px; top: 0px; width: 100%; height: 0px; overflow: visible; display: block; position: absolute; z-index: 106;"></div></div></div><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 0px; top: 0px; width: 100%; height: 100%; overflow: visible; display: none; position: absolute; z-index: 10000; opacity: 0.5; background-color: rgb(255, 255, 255); -webkit-tap-highlight-color: rgba(0, 0, 0, 0);"></div></div></div><div style="margin: 0px; padding: 0px; right: 0px; bottom: 0px; position: absolute; z-index: 100; pointer-events: none;"><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; height: 21px; float: right; pointer-events: none;"><div style="margin: 0px 12px 7px 2px; width: 52px; height: 14px; overflow: hidden; position: relative; pointer-events: auto;"><span style='margin: 0px; padding: 0px 4px; text-align: center; line-height: 11px; font-family: Helvetica,AppleSDGothicNeo-Light,nanumgothic,NanumGothic,"나눔고딕",Dotum,"돋움",sans-serif; font-size: 10px; font-weight: bold; display: block; text-shadow: -1px 0px rgba(255,255,255,0.3), 0px 1px rgba(255,255,255,0.3), 1px 0px rgba(255,255,255,0.3), 0px -1px rgba(255,255,255,0.3);'>50m</span><img width="44" height="4" style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 4px; width: 44px; height: 4px; bottom: 0px; overflow: hidden; display: block; position: absolute; z-index: 2; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important;" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fssl.pstatic.net%2Fstatic%2Fmaps%2Fmantle%2F1x%2Fscale-normal-b.png"><img width="4" height="10" style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; left: 0px; width: 4px; height: 10px; bottom: 0px; overflow: hidden; display: block; position: absolute; z-index: 2; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important;" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fssl.pstatic.net%2Fstatic%2Fmaps%2Fmantle%2F1x%2Fscale-normal-l.png"><img width="4" height="10" style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; width: 4px; height: 10px; right: 0px; bottom: 0px; overflow: hidden; display: block; position: absolute; z-index: 2; min-height: 0px !important; max-height: none !important; min-width: 0px !important; max-width: none !important;" alt="" src="https://img1.daumcdn.net/relay/cafe/original/?fname=https%3A%2F%2Fssl.pstatic.net%2Fstatic%2Fmaps%2Fmantle%2F1x%2Fscale-normal-r.png"></div></div></div><div style="margin: 0px; padding: 0px; left: 0px; bottom: 0px; position: absolute; z-index: 100; pointer-events: none;"><div style="margin: 0px; padding: 0px; border: 0px currentColor; border-image: none; height: 21px; float: left; pointer-events: none;"><div class="map_copyright" style='margin: 0px; padding: 0px 0px 2px 10px; height: 19px; color: rgb(68, 68, 68); line-height: 19px; clear: both; font-family: Helvetica,AppleSDGothicNeo-Light,nanumgothic,NanumGothic,"나눔고딕",Dotum,"돋움",sans-serif; font-size: 11px; white-space: nowrap; pointer-events: none;'><div style="float: left;"><span style="color: rgb(68, 68, 68); white-space: pre;">© NAVER Corp.</span></div><a style='margin: 0px 0px 0px 5px; padding: 0px; color: rgb(68, 68, 68); line-height: 19px; font-family: Helvetica,AppleSDGothicNeo-Light,nanumgothic,NanumGothic,"나눔고딕",Dotum,"돋움",sans-serif; font-size: 11px; text-decoration: underline; float: left; display: none; pointer-events: auto;' href="https://blog.naver.com/PostView.nhn?blogId=bch1588&logNo=221299572762&categoryNo=10&parentCategoryNo=0&viewDate=&currentPage=1&postListTopCurrentPage=&from=postList&userTopListOpen=true&userTopListCount=30&userTopListManageOpen=false&userTopListCurrentPage=1#">더보기</a><div style="float: left;"><a style="color: rgb(68, 68, 68); display: none; white-space: pre; pointer-events: auto;" href="http://www.openstreetmap.org/copyright" target="_blank"><u> /OpenStreetMap</u></a></div></div></div></div><div style="background: rgb(255, 255, 255); padding: 15px; border: 1px solid rgb(41, 41, 48); border-image: none; color: rgb(51, 51, 51); line-height: 1.5; clear: both; font-size: 11px; display: none; position: absolute; max-height: 300px !important; max-width: 350px !important;"><h5 style="font-size: 12px; margin-top: 0px; margin-bottom: 10px;">지도 데이터</h5><a style="top: 8px; width: 14px; height: 14px; text-align: center; right: 8px; color: rgb(68, 68, 68); line-height: 14px; overflow: hidden; font-size: 14px; font-weight: bold; text-decoration: none; display: block; position: absolute;" href="https://blog.naver.com/PostView.nhn?blogId=bch1588&logNo=221299572762&categoryNo=10&parentCategoryNo=0&viewDate=&currentPage=1&postListTopCurrentPage=&from=postList&userTopListOpen=true&userTopListCount=30&userTopListManageOpen=false&userTopListCurrentPage=1#">╳</a><div><span style="color: rgb(68, 68, 68); float: left; white-space: pre;">© NAVER Corp.</span><a style="color: rgb(68, 68, 68); float: left; display: none; white-space: pre; pointer-events: auto;" href="http://www.openstreetmap.org/copyright" target="_blank"> /OpenStreetMap</a></div></div></div></div><div class="se_caption_group is-contact"><div class="se_map_article"><div class="se_title_area"><div class="se_title">부천요양병원</div> 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