스크랩 [천연물 신약 7호] 레일라정(Layla Tab.) - PG201 /한국피엠지제약

[공병희]

모과 Chaenomelis speciosa Nakai (Chaenomelis Fructus, 8 g),
우슬 Achyranthes bibentata Blume (Achyranthis Radix, 8 g),
당귀 Angelica sinensis Oliv. (Angelica Radix, 5 g),
천궁 Cnidium officinale Makino (Cnidii Rhizoma, 5 g),
천마 Gastrodia elata Blume (Gastrodiae Rhizoma, 5 g),
가시오가피 Acanthopanax senticosus Maxim. (Acanthopanacis Cortex, 8 g),
홍화 Carthamus tinctorius L. (Carthami Flos, 5 g),
육계 Cinnamomum aromaticum Nees (Cinnamomi Cortex, 8 g),
진교 Gentiana macrophylla Pall. (Gentianae Macrophyllae Radix, 5 g),
방풍 Ledebouriella seseloides Wolff (Ledebouriellae Radix, 4 g),
위령선 Clematis chinensis Retz. (Clematidis Radix, 5 g),
속단 Phlomis umbrosa Turczaninow (Phlomidis Radix, 4 g) w18, 19x.

(2003)Suppressive_effects_of_PG201,_an_ethanol_extract_from.pdf

(2005)Therapeutic_effects_of_PG201,_an_ethanol_extract_from.pdf

Exp Biol Med (Maywood). 2012 Mar 22. [Epub ahead of print]

Suppressive effects of PG201, an antiarthritic botanical formulation, on lipopolysaccharide-induced inflammatory mediators in Raw264.7 cells.

Choi J, Kim SH, Kim S.

Source

School of Biological Sciences, Seoul National University, Seoul 151-742.

Abstract

PG201, an ethanol extract from a mixture of 12 herbs, has strong antiarthritic activity. To understand the molecular mechanisms underlying its anti-inflammatory effects, PG201-mediated suppression of inflammatory mediators was studied in Raw264.7, a mouse macrophage cell line. PG201 decreased the expression‎! of interleukin (IL)-1β, IL-6 and CC chemokine ligand-2, but not tumor necrosis factor-α, at the protein and mRNA levels in lipopolysaccharide-stimulated Raw264.7 cells. Results from a gel retardation assay indicated that PG201 substantially reduced the DNA-binding activity of the activator protein-1 and cyclic adenosine monophosphate-responsive element-binding protein transcription factors, but not nuclear factor-κB. Western blot and Northern blot analyses showed that PG201 reduced inducible nitric oxide synthase and cytosolic phospholipase A(2) (cPLA(2)) protein expression‎!, but did not affect mRNA expression‎!, ultimately resulting in decreased nitric oxide and prostaglandin E(2). The protein expression‎! of cPLA(2) was decreased by PG201 in the presence of cycloheximide, an inhibitor of translation, suggesting that PG201 may facilitate the degradation of cPLA(2). Taken together, these results suggest that PG201 selectively affects the expression‎! of proteins that play key roles in the inflammatory response at transcriptional and post-translational levels.

-> 원문 못구함;;

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강범아 원문 못구했단다 ㅎㅎㅎ