어제자 abc 뉴스 (새로운 안구 건조 치료약 개발)

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어제자 abc 뉴스 기사입니다.
원문 내용에 간단히 해석을 달았으니 읽어 보시기 바랍니다. 인공 눈물이 아닌 자신의 눈물을 생성 시켜주는 약인가 봅니다.
우리 같은 보상성 환자들은 대개가 안구 건조는 가지고 있지요.도움이 되실 듯 합니다.


But a new eye drop medication helps the body actually increase its own tear production, a new study says.(새로운 약은 실제적으로 눈물 자체의 양을 증가 시킨다)

In a study of 877 patients with moderate to severe dry eye, approximately 60 percent improved their tear production over a six-month period by using a new medicine containing cyclosporine, says study author Dr. Scott Whitcup. (새로운 약을 복용 877명 중 60% 정도가 개선됨)

Whitcup is a California rheumatologist who presented the findings in late October at the American College of Rheumatology's annual scientific meeting.

He also heads clinical research for Allergan, an Irvine, Calif.-based company that manufacturers the drug, sold under the name Restasis. The U.S. Food and Drug Administration approved the drug last December.

"Topical cyclosporine substantially increases tear production in patients with dry eye, not only in patients with autoimmune diseases like Sjögren's syndrome, but also in patients without autoimmune disease," Whitcup says. "The increased tear production was associated with less surface damage to the patients' corneas, so they had less blurring of vision. Also, they used 33 percent less artificial tears."
(이약의 성분은 염증 및 다른 원인으로 인한 안구 건조 모두에 눈물양을 증가 시킴)

Millions of Americans Affected

Dry eye syndrome, formally known as keratoconjunctivitis sicca, is a persistent dryness of the cornea due to decreased function of the tear glands or increased evaporation of tears.
안구 건조는 눈물선의 기능 장애나 눈물의 과다 증발로 발생.

Sufferers experience constant pain from eye irritation, and a sandy or gritty sensation that, if untreated, can lead to scarring or ulceration of the cornea, and eventually loss of vision.
안구 건조자는 눈의 염증으로 지속적인 고통을 받음. 건조함과 껄끄러움. 등등....시력저하 등

An estimated 10 million Americans suffer from dry eye syndrome, according to the Schepens Eye Research Institute in Boston. Most cases result from normal aging of the eyes' tear glands, but dry eye can occur at any age. It affects women more than men.

About 3 million Americans have dry eye as a side effect of Sjögren's syndrome, an autoimmune disease. It also affects about a third of people with other autoimmune diseases such as rheumatoid arthritis. The condition can also be a side effect of drugs used to treat high blood pressure, allergy and depression, Whitcup says.
고혈압 약의 치료나 알레르기 우울증 약의 치료약 부작용(자기 면역 감소)으로도 발생

"It is very uncomfortable and the ocular surface is not protected," says Dr. John W. Shore, an ophthalmic surgeon in Austin, Texas, and president of the American Society of Ophthalmic Plastic and Reconstructive Surgery.

Shore says he's "very familiar with the drug and [I] have started using it in my practice. It seems to work the best in those patients who have autoimmune diseases, but is also good for dry eye in general because it allows the tear film [a layer of mucus that protects the eye] to stabilize and produce more of a person's natural tears, which is healthier for the eye."
이러한 자기 면역 감소 환자나 일반적인 안구 건조 화자 모두에게 효과적임. 자연 눈물을 생성케 도와줌.

He notes, however, the drug takes some time to start to work, usually about three months of twice daily drops, and is expensive, about $100 a month. So Shore only recommends it for severe dry eye.
(약이 반응하기에는 시간이 좀 걸린다. 대개 하루에 2번 석달 동안 치료해야 하며 한달에 100달러 이상이 들만 큼 비싸다. 그러므로 심한 안구 건조자에게 권한다.

"For people who have mild dry eye due to allergies or wind burn, artificial tears is very reasonable. But if I have a patient who's using artificial tears every hour and who has rheumatoid arthritis, he may be a candidate for the drug," Shore says.
바람이나 알레르기 때문에 발생하는 보통의 안구 건조 환자들은 인공 눈물 처방을. 그러나 매시간 인공 눈물 투약자나 류마티즘 관절염 환자에게는 이 약을 권함.

Cyclosporine is a common immunosuppressive drug that is given orally to treat inflammation in certain autoimmune diseases and to prevent transplant rejection. But this topical use of the drug for dry eye has a very small concentration, so it is absorbed into the eye tissue but not detected in the blood, Whitcup says.

이 약은 매우 저농도이므로 안구 조직에 흡수 되어도 혈액에서 발견되지 않음.

"This is important because it makes development of side effects less likely," he says.
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