Re:Re:Treatment of Postherpetic Neuralgia With Intravenous Administration of Zinc Sulfate: A Case Report

BEYOND REASON <a href='javascript:fileFilterViewer("http://cfile297.uf.daum.net/attach/99B1B2365EDD67C214E87A", "/cfile297/99/B1B2365EDD67C214E87A", "Treatment of Postherpetic Neuralgia With Intravenous Administration of Zinc Sulfate- A Case Report.pdf", "grpid%3Dz4ZG%26fldid%3DS3Cq%26dataid%3D505%26fileid%3D2%26regdt%3D20200608071847&url=http%3A%2F%2Fcfile297.uf.daum.net%2Fattach%2F99B1B2365EDD67C214E87A")'><img src="https://t1.daumcdn.net/daumtop_deco/icon/icon.hanmail.net/editor/p_pdf_s.gif" border="0" alt="첨부파일" class="vam"/> Treatment of Postherpetic Neuralgia With Intravenous Administration of Zinc Sulfate- A Case Report.pdf</a> <img src="https://t1.daumcdn.net/cfile/cafe/9919A0475EDD677314" class="txc-image" hspace="1" vspace="1" border="0" actualwidth="1013" width="1013" exif="{}" data-filename="스크린샷 2020-06-08 오전 7.16.50.png" style="clear:none;float:none;" id="A_9919A0475EDD677314E270"/>Gabapentinoids (gabapentin and pregabalin) are first-line drugs for postherpetic neuralgia (PHN), but some PHN patients have inadequate therapeutic response. Zinc deficiency has been identified as a risk factor for PHN. Zinc can alleviate pain through binding to Ca(v)3.2 T-channels and N-methyl-d-aspartate receptors. Mechanisms of gabapentinoids on neuropathic pain include inhibiting N-methyl-d-aspartate receptors and calcium channels. The aforementioned findings provide a molecular pain-relieving basis for zinc supplements as an add-on therapy to pregabalin. We report 2 zinc-deficient PHN patients who received zinc sulfate intravenously as an add-on therapy to pregabalin and responded well.