Re : Metabolic flexibility and insulin resistance. 참 재미있고 의미있는 개념이네..

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새로운 공부의 term이군 ㅎㅎ 

metabolic flexibility

glucose disposal rate,adipose tissue lipid storage, and mitochondrial function on metabolic flexibility

Am J Physiol Endocrinol Metab-2008-Galgani-E1009-17.pdf

panic bird..

Metabolic flexibility and insulin resistance

Jose E. Galgani,^1,2 Cedric Moro,¹ and Eric Ravussin¹

¹Pennington Biomedical Research Center, Baton Rouge, Louisiana; and ²Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile

Submitted 2 July 2008 ; accepted in final form 22 August 2008

ABSTRACT

Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid and insulin resistance.

The metabolic flexibility assessed by the ability to switch from fat to carbohydrate oxidation is usually impaired during a hyperinsulinemic clamp in insulin-resistant subjects; however, this "metabolic inflexibility" is mostly the consequence of impaired cellular glucose uptake. Indeed, after controlling for insulin-stimulated glucose disposal rate (amount of glucose available for oxidation), metabolic flexibility is not altered in obesity regardless of the presence of type 2 diabetes.

To understand how intramyocellular lipids accumulate and cause insulin resistance, the assessment of metabolic flexibility to high-fat diets is more relevant than metabolic flexibility during a hyperinsulinemic clamp. An impaired capacity to upregulate muscle lipid oxidation in the face of high lipid supply may lead to increased muscle fat accumulation and insulin resistance.

Surprisingly, very few studies have investigated the response to high-fat diets. In this review, we discuss the role of glucose disposal rate, adipose tissue lipid storage, and mitochondrial function on metabolic flexibility. Additionally, we emphasize the bias of using the change in respiratory quotient to calculate metabolic flexibility and propose novel approaches to assess metabolic flexibility. On the basis of current evidence, one cannot conclude that impaired metabolic flexibility is responsible for the accumulation of intramyocellular lipid and insulin resistance. We propose to study metabolic flexibility in response to high-fat diets in individuals having contrasting degree of insulin sensitivity and/or mitochondrial characteristics.

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와우..metabolic flexibility에 대한 개념을 한번에 정복할수 있는 좋은 저녈의 좋은 논문이네..두번째 논문은 이걸로 하겠음....역쉬 한개를 애가하면 두개를 캐취하는 탁월한 문원장..홧팅...

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뭐가 한개고 뭐가 두갱고?

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아~~제가 논문 설명 올리면서 문원장과 계속 애기를 한거중에 한개는 목포에서 신나게 놀았던거고 두개는 다시한번 가서 놀자는 애기예요....원장님도 같이 가시면 ㅋㅋㅋㅋㅋ

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좋지 같이 한번 가시죠? ㅎㅎ