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Peripheral precocious puberty
Estrogen or testosterone in your child's body causes this type of precocious puberty.
The less common peripheral precocious puberty occurs without the involvement of the hormone in your brain (GnRH) that normally triggers the start of puberty. Instead, the cause is release of estrogen or testosterone into the body because of problems with the ovaries, testicles, adrenal glands or pituitary gland.
In both girls and boys, the following may lead to peripheral precocious puberty:
In girls, peripheral precocious puberty may also be associated with:
In boys, peripheral precocious puberty may also be caused by:
비타민 D 부족일때
Ann Pediatr Endocrinol Metab. 2014 Jun; 19(2): 91–95.
Published online 2014 Jun 30. doi: 10.6065/apem.2014.19.2.91
PMCID: PMC4114046
PMID: 25077092
Associations between serum vitamin D levels and precocious puberty in girls
Hae Sang Lee, MD, You Jin Kim, MD, Young Seok Shim, MD, Hwal Rim Jeong, MD, Eunbyul Kwon, MD, and Jin Soon Hwang, MD, PhD
Author information Article notes Copyright and License information Disclaimer
This article has been cited by other articles in PMC.
Abstract
Purpose
Vitamin D deficiency has been linked to chronic diseases, such as diabetes mellitus, obesity and autoimmune disease. However, data on the vitamin D status and its association with precocious puberty in girls are limited. We aimed to investigate the association between serum 25-hydroxyvitamin D (25OHD) and precocious puberty in girls.
Methods
A total of 60 girls with central precocious puberty (CPP) and 30 control girls were enrolled. Anthropometric measurement and serum level of 25OHD were estimated for all subjects.
Results
There was a significant difference in the mean serum 25OHD concentration between the precocious puberty group and the control group (17.1±4.5 ng/mL vs. 21.2±5.0 ng/mL, P<0.05). Forty-two of the 60 girls with CPP (70%) had vitamin D deficiency (defined as serum 25OHD<20 ng/mL) and 18 (30%) had vitamin D insufficiency. Of the 30 girls in the control group, vitamin D deficiency was seen in 13 subjects (43.3%), 15 subjects (50%) had vitamin D insufficiency, and 2 subjects (6.7%) had sufficient serum vitamin D (defined as serum 25OHD>30 ng/mL). Vitamin D deficient girls had a significantly higher odds ratio (OR, 3.05; 95% CI, 1.22-7.57, P=0.021).
Conclusion
These results showed that vitamin D levels may be associated with precocious puberty. Further studies are required to establish the potential effect of vitamin D status on puberty.
Keywords: Vitamin D, Precocious puberty, Female
2016년 리뷰논문
https://www.annualreviews.org/doi/pdf/10.1146/annurev-publhealth-031914-122606
Nutritional Determinants of the Timing of Puberty
Abstract
The timing of puberty has important public health, clinical, and social implications. The plasticity of sexual development onset could be a mechanism that adapts to prevailing environmental conditions. Early-life nutrition may provide cues for the environment’s suitability for reproduction. This review focuses on recent developments in our understanding of the role of diet in the timing of sexual maturation. Population-based observational studies consistently indicate that childhood obesity is related to the earlier onset of puberty in girls. Similarly, intake of animal foods has been associated with earlier sexual development, whereas vegetable protein intake is related to delayed maturation. Evidence for prenatal nutrition, infant feeding practices, and childhood intake of fat, carbohydrate, and micronutrients is inconsistent. Secondary analyses of prenatal and early-life randomized nutritional interventions with extended follow-up through peripubertal years would help clarify the role of nutrition in the timing of sexual maturation.
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