<![CDATA[
<p><strong><span style="color: rgb(255, 0, 0);">붉은색</span>은 병용금기</strong></p><p><strong><span style="color: rgb(0, 85, 255);">파란색</span>은 DUR 상 병용금기</strong></p><p><br></p><p><strong><br></strong></p><p><strong>TCA</strong><br></p><table width="700" class="txc-table" style="border: currentColor; border-image: none; font-family: gulim; font-size: 12px; border-collapse: collapse;" border="0" cellspacing="0" cellpadding="0"><tbody><tr><td style="border: 1px solid rgb(204, 204, 204); border-image: none; width: 116px; height: 24px; background-color: transparent;"><p> </p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> amitriptyline</p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;">imipramine</p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;">nortriptyline </p></td><td style="width: 116px; height: 24px; text-align: center; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;">doxepine </p></td><td style="width: 116px; height: 24px; text-align: center; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);">clomipramine</td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> carbamazepine</p></td><td style="width: 350px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> CYP에 경쟁적으로 작용하여</span><span style="font-size: 8pt;"> TCA↓, CBZ<span style="font-size: 8pt;">↑</span></span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><span style="font-size: 8pt;"><p><br></p></span></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"><br></span></p></td></tr><tr><td style="width: 116px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> clonidine</p></td><td style="width: 350px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> α2가 억제되어 clonidine의 효과가 상쇄→혈압↑</span></p></td><td style="width: 116px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> amirodarone</p></td><td style="width: 350px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="color: rgb(0, 85, 255); font-size: 8pt;"> </span><span style="font-size: 8pt;"><span style="color: rgb(0, 85, 255);">Torsade de pointes 위험</span><span style="color: rgb(0, 85, 255);">↑</span></span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> dronedarone</p></td><td style="width: 350px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"><span style="color: rgb(0, 85, 255);"> Torsade de pointes 위험</span><span style="color: rgb(0, 85, 255);">↑</span></span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> selegiline</p></td><td style="width: 582px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="5"><p style="text-align: center; line-height: 1.2;"> <span style="color: rgb(0, 85, 255); font-size: 8pt;">이상고열, 전신경련, 발한, 불온, 혼수 </span></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> moclobemide</p></td><td style="width: 582px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="5"><p style="text-align: center; line-height: 1.2;"> <span style="color: rgb(0, 85, 255); font-size: 8pt;">근독성, 간질, 세로토닌성 증후군</span></p></td></tr><tr><td style="width: 116px; height: 16px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> SSRI</p></td><td style="width: 116px; height: 16px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP이 억제되어 TCA독성↑<span style="font-size: 8pt;"> Serotonin Syn↑</span></span></p></td><td style="width: 116px; height: 16px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> Flu/Ser/Par/Flv: TCA의 간대사↓→독성↑</span></p></td><td style="width: 116px; height: 16px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><span style="font-size: 8pt;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> Flu/Ser/Par/: TCA의 간대사↓→독성↑</span></p></span></td><td style="width: 116px; height: 16px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> Sertraline : CYP2D6억제에 의한 TCA대사↓독성↑</span></p><p style="line-height: 1.2;"><span style="font-size: 8pt;"> Serotonin Syn↑<span style="font-size: 8pt;"><br></span></span></p></td><td style="width: 116px; height: 16px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><br></p><span style="font-size: 8pt;"><p> </p></span><p><br></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> valproic acid</p></td><td style="width: 466px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="4"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> TCA의 1st pass effect↓, 간대사↓→농도↑ 독성↑</span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><br></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> pimozide</p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="color: rgb(0, 85, 255); font-size: 8pt;"> QT연장 </span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 3px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> sumatriptan</p></td><td style="width: 116px; height: 3px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 3px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 3px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 3px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"></td><td style="width: 116px; height: 3px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> <span style="color: rgb(0, 85, 255); font-size: 8pt;"> 세로토닌 증후군</span></p></td></tr><tr><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> Sympathomimetics</p></td><td style="width: 350px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> TCA에 의해 재흡수가 변동되어 BP↑/↓ </span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 12px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td></tr><tr><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> epinephrine</p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="font-size: 8pt;"> amitriptyline 작용</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 12px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Anticholinergics</p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="font-size: 8pt;"> amitriptyline 작용</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 12px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Barbiturates<br></p></td><td style="width: 466px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="4"><p style="text-align: center;"><span style="font-size: 8pt;"> TCA 대사</span><span style="font-size: 8pt;">↑</span><span style="font-size: 8pt;">, 효능↓</span><br></p></td><td style="width: 116px; height: 13px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"></td></tr><tr><td style="width: 116px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> H2 blocker<br></p></td><td style="width: 350px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> TCA 대사</span><span style="font-size: 8pt;">↓</span><span style="font-size: 8pt;">, 1st pass effect</span><span style="font-size: 8pt;">↓</span><span style="font-size: 8pt;">→</span><span style="font-size: 8pt;">농도</span><span style="font-size: 8pt;">↑</span><br></p></td><td style="width: 116px; height: 4px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 4px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td></tr><tr><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> rifamycins</p></td><td style="width: 350px; height: 20px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> TCA 간대사</span><span style="font-size: 8pt;">↑→농도↓</span><br></p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 8px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td></tr><tr><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> trimethoprim</p></td><td style="width: 117px; height: 40px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="2" colspan="1"><p><span style="font-size: 8pt;"> amitriptyline 작용↓</span></p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 8px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> sulfamethoxazole</p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 8px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 8px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> terbinafine<br></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP2D6 억제</span><span style="font-size: 8pt;">→TCA 대사</span><span style="font-size: 8pt;">↓→농도↑독성↑</span><br></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 13px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td></tr><tr><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> 혈압강하제</p></td><td style="width: 117px; height: 20px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="font-size: 8pt;"> 혈압강하제 효과</span><span style="font-size: 8pt;">↓</span><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> quinidine</p></td><td style="width: 117px; height: 40px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="2" colspan="1"><p><span style="font-size: 8pt;"> 병용투여 피함</span></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> amiodarone</p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> ethanol</p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> amitriptyline 작용</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 13px; line-height: 0.5; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr></tbody></table><p> </p><p><strong>SSRI<br></strong></p><table width="700" class="txc-table" style="border: currentColor; border-image: none; font-family: gulim; font-size: 12px; border-collapse: collapse;" border="0" cellspacing="0" cellpadding="0"><tbody><tr><td style="border: 1px solid rgb(204, 204, 204); border-image: none; width: 116px; height: 20px; background-color: transparent;"><p> </p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> fluoxetine</p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;">sertraline</p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> paroxetine</p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> fluvoxamine </p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> citalopram</p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);" colspan="1"><p style="text-align: center;">escitalopram</p></td><td style="width: 116px; height: 20px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);" colspan="1"><p style="text-align: center;">vortioxetine</p></td></tr><tr><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Benzodiazepines<br></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> BDZ의 간대사</span><span style="font-size: 8pt;">↓→농도↑</span><br></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> diazepam</p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> DZP 반감기</span><span style="font-size: 8pt;">↑</span><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 21px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> buspirone<br></p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP3A4 억제</span><span style="font-size: 8pt;">→Bus 농도</span><span style="font-size: 8pt;">↑</span><span style="font-size: 8pt;">(신중투여는 아님)</span><br></p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 9px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> lithium</p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> <span style="font-size: 8pt;">세로토닌증후군</span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> carbamazepine<br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> ?CBZ 농도</span><span style="font-size: 8pt;">↑독성↑</span><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP3A4유도</span><span style="font-size: 8pt;">→Ser대사↑효과↓</span><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 14px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> carvedilol</p></td><td style="width: 261px; height: 14px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><span style="font-size: 8pt;"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> CYP2D6 억제</span><span style="font-size: 8pt;">→</span><span style="font-size: 8pt;">β blocking</span><span style="font-size: 8pt;">↑↑</span><span style="font-size: 8pt;">→BP↓↓</span></p></span></td><td style="width: 116px; height: 14px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 14px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP2D6 억제</span><span style="font-size: 8pt;">→</span><span style="font-size: 8pt;">β blocking</span><span style="font-size: 8pt;">↑↑</span><span style="font-size: 8pt;">→BP↓↓</span></p></td><td style="width: 116px; height: 14px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 14px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> domperidone</p></td><td style="width: 87px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 177px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="2"><p style="line-height: 1.2;"> <span style="color: rgb(0, 85, 255); font-size: 8pt;">QTc 연장 효과</span><span style="font-size: 8pt;"><font size="2"><span style="color: rgb(0, 85, 255); font-size: 8pt;">증대로 심각한 위험(Torsade de Pointes, 심각한 심실성 부정맥 포함) 가능성 </span></font></span></p></td><td style="width: 116px; height: 51px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Phenothiazine</p></td><td style="width: 87px; height: 26px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="font-size: 8pt;"> 출혈위험</span><span style="font-size: 8pt;">↑</span><br></p></td><td style="width: 87px; height: 26px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 26px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> pimozide</p></td><td style="width: 261px; height: 26px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center;"><span style="color: rgb(0, 85, 255); font-size: 8pt;"> QT연장 </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="color: rgb(0, 85, 255); font-size: 8pt;"> QT연장 </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> perphenazine<br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP 2D6 억제</span></p><p style="line-height: 1.2;"><span style="font-size: 8pt;">→PPZ대사</span><span style="font-size: 8pt;">↓</span><span style="font-size: 8pt;">농도</span><span style="font-size: 8pt;">↑</span><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> risperidone<br></p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP 2D6 억제<span style="font-size: 8pt;">→Ris</span><span style="font-size: 8pt;">↑<span style="font-size: 8pt;"> Serotonin Syn↑</span><br></span></span></p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 11px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 10px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> clozapine</p></td><td style="width: 174px; height: 10px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="2"><span style="font-size: 8pt;"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> CLZ의 간대사</span><span style="font-size: 8pt;">↓→농도</span><span style="font-size: 8pt;">↑독성↑</span></p></span></td><td style="width: 116px; height: 10px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 175px; height: 10px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="2"><p style="text-align: center;"><span style="font-size: 8pt;"> <span style="font-size: 8pt;">CLZ의 간대사</span><span style="font-size: 8pt;">↓→농도</span><span style="font-size: 8pt;">↑독성↑</span></span></p></td><td style="width: 116px; height: 10px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 10px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> olanzapine<br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP</span><span style="font-size: 8pt;">2D6 억제</span><span style="font-size: 8pt;">→OLZ대사</span><span style="font-size: 8pt;">↓농도↑</span><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> cyproheptadine</p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> 5HT Rc가 차단되어 SSRI의</span><span style="font-size: 8pt;"> 효과</span><span style="font-size: 8pt;">↓</span></p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 12px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> cyclosporine<br></p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><font size="2"> <span style="font-size: 8pt;">CYP3A4 억제</span></font><span style="font-size: 8pt;">→Cyclo</span> 농도<span style="font-size: 8pt;">↑독성↑</span><br></p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 31px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> hydantoins<br></p></td><td style="width: 174px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="2"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> Hydantoin 대사</span><span style="font-size: 8pt;">↓</span><span style="font-size: 8pt;">→</span><span style="font-size: 8pt;">농도↑독성↑</span><br></p></td><td style="width: 116px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 6px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> NSAIDs</p></td><td style="width: 436px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="5"><p style="text-align: center;"><span style="font-size: 8pt;"> <span style="font-size: 8pt;">? 위장관계 부작용</span><span style="font-size: 8pt;">↑ </span></span><span style="font-size: 9pt;">출혈위험</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 116px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> aspirin</p></td><td style="width: 87px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="font-size: 8pt;"> </span><span style="font-size: 8pt;">출혈위험</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 87px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 1px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> tramadol</p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> <span style="font-size: 8pt;">세로토닌증후군</span></p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Tiptans<br></p></td><td style="width: 436px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="5"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> 5HT Rc 자극</span><span style="font-size: 8pt;">→</span><span style="font-size: 8pt;">Serotonin Syn</span><span style="font-size: 8pt;">↑<br></span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 18px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> TCAs<br></p></td><td style="width: 116px; height: 18px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> 출혈위험</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 262px; height: 18px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="font-size: 8pt;"> CYP2D6</span><span style="font-size: 8pt;">↓→TCA농도↑</span><span style="font-size: 8pt;">독성</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 116px; height: 18px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 18px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 18px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> 기타항우울약</p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> 다른 항우울제의 </span><span style="font-size: 8pt;">혈장농도↑</span><br></p></td><td style="width: 262px; height: 0px; line-height: 1.2; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center;"> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> MAO Inhibitors<br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> 세로토닌증후군</span></p></td><td style="width: 262px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center; line-height: 1.2;"><span style="color: rgb(255, 0, 0); font-size: 8pt;"> 5HT 축적</span><span style="color: rgb(255, 0, 0); font-size: 8pt;">↑ <span style="font-size: 8pt;"><span style="color: rgb(255, 0, 0);">→Serotonin Syn</span><span style="color: rgb(255, 0, 0); font-size: 8pt;">↑</span></span><br></span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> 5HT 축적</span><span style="font-size: 8pt;">↑</span></p><p style="line-height: 1.2;"><span style="font-size: 8pt;">→Serotonin Syn<span style="font-size: 8pt;">↑</span></span><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> moclobemide</p></td><td style="width: 436px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="5"><p style="text-align: center;"><font color="#0055ff" size="2"><span style="font-size: 8pt;"> 세로토닌성 증후군</span></font></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p style="line-height: 1;"><font color="#0055ff" size="2"><span style="font-size: 8pt;"> 세로토닌성 증후군</span></font></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> selegiline</p></td><td style="width: 349px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="4"><p style="text-align: center;"> <font color="#0055ff" size="2"><span style="font-size: 8pt;">세로토닌성 증후군</span></font></p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p style="text-align: center;"> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; line-height: 1; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><font color="#0055ff" size="2"><span style="font-size: 8pt;"> 세로토닌성 증후군</span></font></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> tryptophan</p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p><span style="font-size: 8pt;"> </span><span style="font-size: 8pt;">세로토닌증후군</span></p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> agomelatine</p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 87px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"> <span style="font-size: 8pt;">agomlatine 혈중농도</span><span style="font-size: 8pt;">↑</span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Anorectics<br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 262px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center;"><span style="font-size: 8pt;"> ?Anorectics 효과</span><span style="font-size: 8pt;">↑ <span style="font-size: 8pt;">Serotonin Syn↑<br></span></span></p></td><td style="width: 116px; height: 0px; text-align: center; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> zolpidem<br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> ZPD 대사↓→발현시간↓효과↑</span><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> ritonavir<br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP2D6억제</span><span style="font-size: 8pt;">→Ritonavir↑ & Serotonin Syn↑</span><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> tizanidine</p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> </span><span style="color: rgb(0, 85, 255); font-size: 8pt;">장기화된 저혈압, 졸음, 현기증 및 정신운동능력 감소</span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> wafarin</p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> 혈장농도변화</span></p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> digoxin</p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><span style="font-size: 8pt;"> 혈장농도변화</span><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td></tr></tbody></table><p><br></p><p><strong>Other Antidepressants<br></strong></p><table width="700" class="txc-table" style="border: currentColor; border-image: none; font-family: gulim; font-size: 12px; border-collapse: collapse;" border="0" cellspacing="0" cellpadding="0"><tbody><tr><td style="border: 1px solid rgb(204, 204, 204); border-image: none; width: 116px; height: 24px; background-color: transparent;"><p> </p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> venlafaxine</p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);" colspan="1"><p style="text-align: center;">desvenlafaxine</p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);" colspan="1"><p style="text-align: center;">duloextine</p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;">bupropion </p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;">mirtazapine</p></td><td style="width: 116px; height: 24px; border-top-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-top-width: 1px; border-right-width: 1px; border-bottom-width: 1px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; background-color: rgb(228, 247, 186);"><p style="text-align: center;"> trazodone</p></td></tr><tr><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> carbamazepine</p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP3A4 유도</span><span style="font-size: 8pt;">→Bup 대사</span><span style="font-size: 8pt;">↑→농도</span><span style="font-size: 8pt;">↓</span></p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td></tr><tr><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> domperidone</p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="color: rgb(0, 85, 255); font-size: 8pt;">QTc 연장 효과</span><span style="font-size: 8pt;"><font size="2"><span style="color: rgb(0, 85, 255); font-size: 8pt;">증대로 심각한 위험(Torsade de Pointes, 심각한 심실성 부정맥 포함) 가능성 </span></font></span></p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 25px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="color: rgb(0, 85, 255); font-size: 8pt;">QTc 연장 효과</span><span style="font-size: 8pt;"><font size="2"><span style="color: rgb(0, 85, 255); font-size: 8pt;">증대로 심각한 위험(Torsade de Pointes, 심각한 심실성 부정맥 포함) 가능성 </span></font></span></p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> hydantoin</p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP3A3/4유도→Mir대사↑→농도↓</span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> warfarin</p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> ?Prothrobine Time 영향</span></p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> Tiptans<br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> 5HT Rc 자극</span><span style="font-size: 8pt;">→</span><span style="font-size: 8pt;">Serotonin Syn</span><span style="font-size: 8pt;">↑<br></span></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> fluvoxamine</p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> <font color="#0055ff" size="2"><span style="font-size: 8pt;">세로토닌성 증후군</span></font></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> MAO Inhibitors<br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><font size="2"><span style="color: rgb(255, 0, 0); font-size: 8pt;"> 5HT 축적</span></font><span style="font-size: 8pt;"><span style="color: rgb(255, 0, 0);">↑</span></span></p><p style="line-height: 1.2;"><span style="font-size: 8pt;"><span style="color: rgb(255, 0, 0); font-size: 8pt;">→Serotonin Syn</span><span style="color: rgb(255, 0, 0); font-size: 8pt;">↑</span></span><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="1"><p> </p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td><td style="width: 116px; height: 24px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p><br></p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> moclobemide</p></td><td style="width: 300px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center;"> <font color="#0055ff" size="2"><span style="font-size: 8pt;">세로토닌성 증후군</span></font></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> <font color="#0055ff" size="2"><span style="font-size: 8pt;">세로토닌성 증후군</span></font></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);" rowspan="1"><p> selegiline</p></td><td style="width: 300px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1" colspan="3"><p style="text-align: center;"> <font color="#0055ff" size="2"><span style="font-size: 8pt;">세로토닌성 증후군</span></font></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> bupropion의 급성 독성 증가</span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> <font color="#0055ff" size="2"><span style="font-size: 8pt;">세로토닌성 증후군</span></font></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" rowspan="1"><p> </p></td></tr><tr><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-left-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-left-width: 1px; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; background-color: rgb(212, 244, 250);"><p> Antiviral Agents</p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;" colspan="1"><p> </p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p><span style="font-size: 8pt;"> </span></p></td><td style="width: 116px; height: 0px; border-right-color: rgb(204, 204, 204); border-bottom-color: rgb(204, 204, 204); border-right-width: 1px; border-bottom-width: 1px; border-right-style: solid; border-bottom-style: solid;"><p style="line-height: 1.2;"><span style="font-size: 8pt;"> CYP3A4 억제→Trz대사↓농도↑</span></p></td></tr></tbody></table><p><br></p><p><a href='javascript:fileFilterViewer("http://cfile288.uf.daum.net/attach/994F48435B6A9AF80744F0", "/cfile288/99/4F48435B6A9AF80744F0", "노인에 대한 의약품 적정사용 정보집 2009전문가용.pdf", "grpid%3D1X6xv%26fldid%3DI11u%26dataid%3D6%26fileid%3D1%26regdt%3D20180808162558&url=http%3A%2F%2Fcfile288.uf.daum.net%2Fattach%2F994F48435B6A9AF80744F0")'><img src="https://t1.daumcdn.net/daumtop_deco/icon/icon.hanmail.net/editor/p_etc_s.gif" border="0" alt="첨부파일" class="vam"/> 노인에 대한 의약품 적정사용 정보집 2009전문가용.pdf</a><br></p><p><a href='javascript:fileFilterViewer("http://cfile283.uf.daum.net/attach/99ED6B435B6A9AF9172E7C", "/cfile283/99/ED6B435B6A9AF9172E7C", "신질환자에 대한 의약품 적정사용 정보집.pdf", "grpid%3D1X6xv%26fldid%3DI11u%26dataid%3D6%26fileid%3D2%26regdt%3D20180808162558&url=http%3A%2F%2Fcfile283.uf.daum.net%2Fattach%2F99ED6B435B6A9AF9172E7C")'><img src="https://t1.daumcdn.net/daumtop_deco/icon/icon.hanmail.net/editor/p_etc_s.gif" border="0" alt="첨부파일" class="vam"/> 신질환자에 대한 의약품 적정사용 정보집.pdf</a></p><p><br></p>
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