moon's integration medicine 핵심 키워드 & 그림

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핵심 키워드와 그림

https://go.drugbank.com/drugs/DB09270

Ubidecarenone: Uses, Interactions, Mechanism of Action | DrugBank Online

https://examine.com/supplements/taurine/

Taurine Health benefits, dosage, safety, side-effects, and more | Supplements - Examine

ER associated protein degradation(ERAD)

ER stress-induced cell death mechanisms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834229/

ER stress 25% 정도의 ROS 생성

The ER provides an oxidizing environment to facilitate disulfide bond formation and this process is believed to contribute to as much as 25% of the overall ROS generated [68, 69]

조직의 지방화 - 간에서는 유독 지방간이 발생하는가? 

lipid metabolism을 하는 smooth ER이 크다...

ER lumen에 UPR 증가, 지질대사 이상으로 구조적 변화가 발생하는가? - 메타인지

ER stress 상황에서 만들어진 UPR 단백질은 auto-phagosome되어 degradation 됨. - 프레테아좀...

ER stress marker?

ER stress inhibitor

ER stress is a potent inducer of inflammation

https://www.spandidos-publications.com/10.3892/mmr.2021.12242

세포 노화 irreversible cell cycle arrest

Cellular senescence, the non-dividing altered state into which many vertebrate cells enter when stressed, was first formally described by Hayflick and Moorhead in the early 1960s.

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic changes. Among these changes is the release of numerous biologically active molecules collectively known as the senescence-associated secretory phenotype, or SASP.

https://www.nature.com/articles/s42255-021-00483-8

알츠하이머 

Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized pathologically by massive extracellular deposition of amyloid-β (Aβ) forming senile plaques and intracellular accumulation of the abnormally modified tau proteins forming neurofibrillary tangles (NFTs)

Tau fibers

Iron death

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. 

https://www.nature.com/articles/s41419-020-2298-2

• Review Article -Nature
• Open Access
• Published: 28 June 2021

Implication of ferroptosis in aging