약학대학은 아니고 관련 연구실, 서울대학교 치의학대학원 바이오폴리머, 유전자 치료 연구실에서 석/박사, 인턴,연구원 모집합니다.

[mivs]

연구분야

약학, 약물전달/유전자 전달, 바이오소재

Pharmaceutics, Drug Delivery/Gene Delivery, Biomaterials design

세부연구내용

본 연구실에서는 연구와 치료목적의 폴리머를 연구하고 있습니다. 학생들은 non-viral gene therapy 에 이용될 폴리머를 만들고 이를 특정 세포에 선택적이고 효과적으로 전달하는 연구를 수행하게 됩니다.

연구주제명

Synthesis, characterization and eval‎‍uation of poly (ester amine)s as non-viral Gene carriers

연구의 개요

생분해성 폴리너는 원하는 세포에 유전자 (transgene) 을 전달하는데 매우 유용합니다. 이러한 시스템은 다른 방법들 (예를 들면 cationic lipid나 electroporation 등) 보다 전달된 유전자가 훨씬 강력하고 오래도록 발현되게끔 합니다. 이러한 유전자 전달 시스템은 연구목적의 세포배양에서 유전자를 도입하거나 이른바 gene therapy라고 통칭되는 임상적용 기법에 이용됩니다. 이때의 핵심 이슈는 vector의 tropism, 즉 특정 세포에만 선택적으로 유전자를 전달하는 vector의 특성이 원하는 세포 타입에 따라 잘 조절되어야 한다는 점입니다.  예를 들어 파킨슨병의 치료를 위해서라면 뇌안에서도 해당 신경 (즉, substantia nigra 의 신경)에만 유전자가 전달되어야 합니다.  만약 다른 신경에까지 유전자 전달이 이루어지면 원치 않는 부작용이 나타나게 됩니다. 하지만 vector의 유전자 전달 선택성을 개선하기 위해 많은 연구시도가 있어왔지만 아직도 획기적인 수준의 기술적 발전이 아쉬운 상황입니다.  본 연구실에서는 임상 및 연구목적의 세포특이적 유전자전달을 가능케하는 원리를 연구하고 있습니다.

모집 대상

1.       약학 Pharmacy

2.       재료공학 Material Sciences

3.       생물학 Biology

4.       분자생물학 Molecular Biology

5.       생명공학 Biotechnology

6.       화학 Chemistry

 관련 학부 우대

지원 사항 : 연구 수당 지급 (등록금 + 연구비)

지도 교수님

Rohidas B. Arote

E‐mail 주소

rohi06@snu.ac.kr (+82 02 740 8770)

서울대학교 치의학대학원 치의과학과

Vacancy for Researcher/MS/PhD in Seoul National University

Subject area

Pharmaceutics, Drug Delivery/Gene Delivery, Biomaterials design

Detailed subject area

We work with design and engineering of polymers to be used for research and therapy application. In the proposed project the student will create polymers that can be used as non-viral gene carriers in cancer gene therapy, with the goal of being able to efficiently control delivery of genes to a desired cell type.

Title of project

Synthesis, characterization and eval‎‍uation of poly (ester amine)s as non-viral Gene carriers

Short description of project

The use of biodegradable polymer is regarded as a preferred route for specific delivery of transgenes to desired cells. These systems give a strong and long‐lasting expression‎‍ of the transgene compared to gene delivery by other procedures, e. g. utilizing cationic lipids or electroporation. They are used to deliver transgenes to cells in culture for research purposes and are also in development for clinical applications, so called gene therapy applications. For many applications, it is required that the tropism

(The specificity in delivery of the transgene to a particular cell type) of the vector can be controlled and altered depending on the cell type in question. An example of an application where it would be important is treatment of parkinson's disease, where it would be desirable to deliver a particular gene to a sub‐set of neurons in the brain, whereas delivery of the gene to other sub‐sets of neurons in the brain would lead to unwanted side‐effects. Although different approaches have been investigated so far to confer specificity in gene delivery of the vectors, technical shortcomings at different levels have been hampering for the field. The purpose of the proposed project is to explore novel principles to achieve selective targeting of viral vectors to desired cells, for delivery of harbored transgenes for therapeutic and research applications.

Students Majoring in,

1.       Pharmacy

2.       Material Sciences

3.       Biology

4.       Molecular Biology

5.       Biotechnology

6.       Chemistry  are preferred

Benefits: Tuition Fees and living expenses support

 Name of responsible professor

Rohidas B. Arote

Contact

rohi06@snu.ac.kr (+82 02 740 8770)

School of Dentistry, Seoul National University

더 자세한 모집요강은

http://admission.snu.ac.kr/graduate/fall/guide