Re:수소수(hydrogen rich water) 심장질환의 치료와 예방에 효과가 있다는 2019 review 논문

[문형철]

beyond reason

molecules-24-02076.pdf

수소는 가스로 흡입, 물로 마시기, 주사로 주입하기 3가지 방법이 있음. 

Hydrogen is primarily administered via inhalation, drinking hydrogen-rich water, or injection of hydrogen-rich saline

 Review

A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Eects of Oxidative Stress

TylerW. LeBaron 1,2 , Branislav Kura 1, Barbora Kalocayova 1, Narcis Tribulova 1 and

Jan Slezak 1,*

1 Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences,

Bratislava 841 04, Slovak Republic; LeBaronT@molecularhydrogeninstitute.com (T.W.L.);

branislav.kura@savba.sk (B.K.); barbora.kalocayova@savba.sk (B.K.); narcisa.tribulova@savba.sk (N.T.)

2 Molecular Hydrogen Institute, Enoch City, UT, 847 21, USA

* Correspondence: jan.slezak@savba.sk; Tel.: +421-903-620-181

Academic Editor: Morris Karmazyn

Received: 24 April 2019; Accepted: 24 May 2019; Published: 31 May 2019

Abstract: 

Cardiovascular diseases are the most common causes of morbidity and mortality worldwide. Redox dysregulation and a dyshomeostasis of inflammation arise from, and result in, cellular aberrations and pathological conditions, which lead to cardiovascular diseases. Despite years of intensive research, there is still no safe and effective method for their prevention and treatment.

Recently, molecular hydrogen has been investigated in preclinical and clinical studies on various diseases associated with oxidative and inflammatory stress such as radiation-induced heart disease, ischemia-reperfusion injury, myocardial and brain infarction, storage of the heart, heart transplantation, etc. 

Hydrogen is primarily administered via inhalation, drinking hydrogen-rich water, or injection of hydrogen-rich saline. It favorably modulates signal transduction and gene expression‎ resulting in suppression of proinflammatory cytokines, excess ROS production, and in the activation of theNrf2 antioxidant transcription factor. Although H2 appears to be an important biological molecule with anti-oxidant, anti-inflammatory, and anti-apoptotic effects, the exact mechanisms of action remain elusive. There is no reported clinical toxicity; however, some data suggests that H2 has a mild hormetic-like effect, which likely mediate some of its benefits. The mechanistic data, coupled with the pre-clinical and clinical studies, suggest that H2 may be useful for ROS/inflammation-induced cardiotoxicity and other conditions.