장 속의 높은 프리보텔라 균 비율은 자폐 증상과 유관

[마운틴듀2]

https://www.facebook.com/share/p/1JjKuGFLBD/

The GUT CLUB

High Prevotella is a frequent autism feature, one explanation is anti-NMDAR encephalitis, but also pathogens (fungi, protozoans, viruses) at root of both:
"Prevotella was significantly increased, while Bacteroides was reduced in the gut microbiota of the patients, compared with the controls."

"Evidence of many beneficial functions of Bacteroides strains suggests their intervention capabilities in lipopolysaccharide-induced immune response and gut microbiome shift, even having potential as therapeutic probiotics to prevent inflammatory disorders [18, 19]. The polysaccharide A surface component of Bacteroides fragilis is mainly responsible for this protective effect [20]. The expression‎ of polysaccharide A can also protect against central nervous system demyelination [21]. Therefore, reduced Bacteroides in anti-NMDAR encephalitis may result in a decline in this protective effect, increasing the chance of the disease."

"we hypothesized that increased Prevotella levels may decrease the number of CD20+ B lymphocytes, which may be a protective factor against anti-NMDAR encephalitis."

https://link.springer.com/article/10.1186/s12883-022-02804-0?fbclid=IwdGRjcAUXXLVjbGNrBRdcqnBkb2YBZXh0bgNhZW0CMTEAc3J0YwZhcHBfaWQMMzUwNjg1NTMxNzI4AAEefAFj1FX7eMiRg2blpj9evWC7xlbnW3DaFqgRHoe7QgKyUdTOjoz4OzNZDHY_aem_5QBwlRyj-QDM0FCFePyfyw