세원셀론텍 091090
런던대학과 세포배양서비스 공급체결
세원셀론텍은 RMS UK는 런던대학의 영리를 추구하는 교육법인 런던대학비즈니스주식회사와 총 200만 파운드(한화 약 40억 원)규모로 설립하게 되며,양측이 각각 50대50으로 현금을 투자
The researchers from UCL Institute of Child Health and UCL Institute of Ophthalmology, also members of the UCL Centre for Stem Cells and Regenerative Medicine, successfully implanted cells from healthy mice into mice with an inherited form of childhood blindness called Leber Congenital Amaurosis (LCA).
The implanted cells express a gene called Crx which is needed to make healthy cone and rod photoreceptors. The cells were able to integrate with the retina and become new cone photoreceptors. This is the first time this has been achieved. Further studies are needed to demonstrate whether it is possible to restore sight using this method.
Dr Jane Sowden from the UCL Institute of Child Health, who led the study, said: “We have shown for the first time that it is possible to transplant new cone photoreceptors into the mature retina. The newly-developed cones looked as good as new. This is an important step forward as cone photoreceptors are essential for reading vision and for colour vision and loss of this type of cell has the biggest impact on sight.
“It may be possible to translate this success into treatments for humans. Recent research has shown that embryonic stem cells capable of self-renewal could provide an equivalent source of human cells that express the Crx ‘photoreceptor-creating’ gene and could be grown in the lab before being transplanted in the retina.”
Professor Robin Ali from UCL Institute of Ophthalmology, who co-led the study, said: “We are now working to assess how much vision can be improved by photoreceptor cell transplantation and how effectively they can replace degenerating cells at different stages of disease. There is still a lot more basic research that needs to be carried out, but this is a very promising area that we hope will translate into a future treatment for patients who cannot see because their photoreceptors have degenerated.”
One in 3,000 people are affected by incurable genetically inherited retinal disease. LCA is the most severe form that causes blindness from birth or during the first few months of life and affects around 200,000 children worldwide. These diseases cause the light sensitive photoreceptor cells in the retina to die, leading to loss of sight.
‘Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells’ is published in Human Molecular Genetics today. The research was funded by the MRC, the Macula Vision Research Foundation and Fight for Sight.
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