후코이단의 항암 활동의 치료 가능성: 현재의 발전과 장애물

출처 : <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/" target="_top" class="ke-link">The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles - PubMed (nih.gov)</a>The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles<a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/?term=Jin+JO&cauthor_id=34068561" target="_top" class="ke-link">Jun-O Jin</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-1" target="_top" class="ke-link">1</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-2" target="_top" class="ke-link">2</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-3" target="_top" class="ke-link">3</a>, <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/?term=Chauhan+PS&cauthor_id=34068561" target="_top" class="ke-link">Pallavi Singh Chauhan</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-4" target="_top" class="ke-link">4</a>, <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/?term=Arukha+AP&cauthor_id=34068561" target="_top" class="ke-link">Ananta Prasad Arukha</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-5" target="_top" class="ke-link">5</a>, <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/?term=Chavda+V&cauthor_id=34068561" target="_top" class="ke-link">Vishal Chavda</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-6" target="_top" class="ke-link">6</a>, <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/?term=Dubey+A&cauthor_id=34068561" target="_top" class="ke-link">Anuj Dubey</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-7" target="_top" class="ke-link">7</a>, <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/?term=Yadav+D&cauthor_id=34068561" target="_top" class="ke-link">Dhananjay Yadav</a> <a style="color: #608cba;" href="https://pubmed.ncbi.nlm.nih.gov/34068561/#affiliation-2" target="_top" class="ke-link">2</a>Affiliations PMID: 34068561 PMCID: <a style="color: #608cba;" href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8151601/" target="_top" class="ke-link">PMC8151601</a> DOI: <a style="color: #608cba;" href="https://doi.org/10.3390/md19050265" target="_top" class="ke-link">10.3390/md19050265</a>Free PMC articleAbstractSeveral types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review.<hr data-ke-style="style1">후코이단의 항암 활동의 치료 가능성: 현재의 발전과 장애물여러 유형의 암은 세포 및 분자 행동을 공유합니다. 많은 화학요법 약물이 암세포의 방어력을 약화시키도록 설계되었지만 이러한 약물은 건강한 조직에 세포독성 효과를 나타낼 수도 있습니다. 갈조류에서 추출한 황산화 푸코스 기반 다당류인 후코이단은 여러 암 유형에 대한 항암 효과로 인해 항암제로 많은 주목을 받았습니다. 후코이단의 항암 기전 중에는 세포 주기 정지, 세포 사멸 유도, 세포 독성 자연 살해 세포 및 대식세포의 자극이 있습니다. 후코이단은 또한 화학 요법 약물 및 방사선 유발 손상과 관련된 독성으로부터 보호합니다. 기존 항암제와 후코이단의 시너지 효과로 인해 연구자들은 후코이단의 치료 가능성을 탐구하게 되었습니다. 이 검토는 후코이단이 종양 성장을 늦추고, 암세포를 죽이고, 암 화학요법 약물과 상호 작용하는 메커니즘을 편집합니다. 후코이단을 항암제로 개발하는 것과 관련된 장애물도 이 리뷰에서 논의됩니다.<hr data-ke-style="style1">고순도 와우 후코이단의 특권을 누려보세요전화 주시면 성심성의껏 상담해 드립니다.<div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/1YJ2q/908faa496eaac3885f143c5ad906915eb46485e3" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/1YJ2q/908faa496eaac3885f143c5ad906915eb46485e3" data-origin-width="740" data-origin-height="224"></div><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/1YJ2q/3f452e62b22b0f0f7d5c78d642ebbe2bc6b378ab" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/1YJ2q/3f452e62b22b0f0f7d5c78d642ebbe2bc6b378ab" data-origin-width="740" data-origin-height="373"></div><div class="figure-img" data-ke-type="image" data-ke-style="alignCenter" data-ke-mobilestyle="widthOrigin"><img src="https://t1.daumcdn.net/cafeattach/1YJ2q/e03188dadbffeeff6ec878dfac739c79fbd3c2da" class="txc-image" data-img-src="https://t1.daumcdn.net/cafeattach/1YJ2q/e03188dadbffeeff6ec878dfac739c79fbd3c2da" data-origin-width="740" data-origin-height="215"></div><a href="https://blog.naver.com/wowntp/221521277875" target="_blank" class="ke-link">https://blog.naver.com/wowntp/221521277875</a><div class="figure-open" contenteditable="false" data-ke-type="opengraph" data-ke-align="alignCenter" data-og-type="website" data-og-title="와우후코이단 과립스틱 정제품 소개" data-og-description="와우후코이단 과립스틱 정제품 소개 와우 후코이단(과립) 스틱 제품 식품유형 : 고형차 내용량&n..." data-og-host="blog.naver.com" data-og-source-url="https://blog.naver.com/wowntp/221521277875" data-og-url="https://blog.naver.com/wowntp/221521277875" data-og-image="https://scrap.kakaocdn.net/dn/sd3vk/hyVqwpgE4g/tIvX2K2ayGslievRSqnWJ1/img.jpg?width=700&height=873&face=0_0_700_873"><a href="https://blog.naver.com/wowntp/221521277875" target="_blank" data-source-url="https://blog.naver.com/wowntp/221521277875"><div class="og-image"><img src="https://scrap.kakaocdn.net/dn/sd3vk/hyVqwpgE4g/tIvX2K2ayGslievRSqnWJ1/img.jpg?width=700&height=873&face=0_0_700_873" alt="" xxonerror="this.src="//img1.kakaocdn.net/thumb/C200x200/?fname=https%3A%2F%2Ft1.daumcdn.net%2Fcafe_image%2Fcafe_meta_image_190529.png""></div><div class="og-text">와우후코이단 과립스틱 정제품 소개와우후코이단 과립스틱 정제품 소개 와우 후코이단(과립) 스틱 제품 식품유형 : 고형차 내용량&n...blog.naver.com</div></a></div>