여드름 뉴스..오보인듯 합니다만..

[흉터지우개]

미국 사이트가서 원문으로 추정되는 거 봤습니다.

국내 뉴스로 오면서 뭔가 질환명에 대한 오해가 있었던듯..? --; 방송내내 자료화면과 미국의사 인터뷰에도 '여드름;acne vulgaris' 란 단어는 한마디도 안나오데요.. 'rosacea' 라고 명확히 발음하던데..

요약해보면..'주사' 는 영어로 'rosacea' 인데..미국 일반인 애덜은 'acne rosacea, adult acne' 라도도 부르구요..(우리나라에서 말하는 성인 여드름과는 다른의미)<---요 'acne ' 란 단어에서 오해가 생긴듯..기자가 오해했는지..?

주사는 백인 30-60세에 흔하고 많이 고생들 합니다.. 그동안 원인기전이 명확하지 않았는데 미노싸이클린이나 독시싸이클린 같은 항생제 쓰니 좀 좋아지는 경우가 있었어요..그런데 이게 균이 원인이라고 오해했던게 아니구요..미국에서도 써보니 좋아지는데 기전은 정확히 모르고 있었어요..그런데 이번에 연구에서 두가지 단백질이 관련있을거란 결과가 나왔구요. 백인들 상당수가 고생하던 질환이니 난리가 났네요..^^;

항생제가 효과 나타냈던것도 이 두단백질에 어떤 작용을 해서 그런것 같다네요..

주사와 여드름은 다른 질환입니다.

참고로 미국피부과교과서에도 'acne rosacea'란 병명은 'acne vulgaris; 우리가 아는 여드름' 와 혼동을 줄 수 있으므로 부적절한 용어이다.라고 까지 되어있어요..미국애덜도 헷갈리는데 우리나라로 오면서 더 그럴수도 있겠네요..^^;

논문 제목입니다.

Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea <--여드름이 아닙니다.

Kenshi Yamasaki, Anna Di Nardo, Antonella Bardan, Masamoto Murakami, Takaaki Ohtake, Alvin Coda, Robert A Dorschner, Chrystelle Bonnart, Pascal Descargues, Alain Hovnanian, Vera B Morhenn, Richard L Gallo SUMMARY: Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema,

CONTEXT: ...the clinical changes seen in rosacea, we considered that abnormal expression‎ of cathelicidin peptides may be a factor in its pathogenesis. To test whether the expression‎ of cathelicidin is altered in rosacea, skin biopsies were...

Nature Medicine (05 Aug 2007) Letters

다음은 미국 뉴스 원문..

A new study by scientists from the US, France and Japan appears to have found what causes acne rosacea to develop, a common inflammatory skin ailment that affects the over 30s and is also known as adult acne.<--성인 여드름으로 일반인에 알려졌다는군요..우리나라에서 말하는 성인여드름과는 좀 다릅니다. 여기서는 '주사'를 의미합니다. The research is published in the advanced online edition of the journal Nature Medicine and was led by Dr Richard L. Gallo, professor of medicine and chief of the Division of Dermatology at the University of California, San Diego (UCSD) School of Medicine and the Dermatology section of the Veterans Affairs San Diego Healthcare System. Acne rosacea is an inflammatory skin disease that affects about 14 million Americans between the age of 30 and 60 and is more common in women than in men. It is more likely to affect fair skinned people of European or Celtic descent. <--백인들 무지 고생하네요..30-60세의 남자보다 여자에서 생기는..여드름주사(<--요 용어도 문제 있음.미국의사들도 여드름(acne vulgaris) 와 혼동을 야기할 수 있으므로 부적절한 용어라고 하며 그냥 'rosacea' 가 정식 명칭입니다...Rosacea is characterized by facial redness (erythema), bumps and pimples (papulopustules), and spider veins (telangiectasia). The condition is chronic and gets worse over time. It is cyclical and flares up for weeks and months and then subsides. There is no effective treatment although antibiotics are sometimes prescribed with mixed results.<--결국은 'rosacea(주사) 이야기.. Triggers for rosacea usually involve anything that causes the face to become flushed such as demanding exercise, sunburn, stress, anxiety, and sudden changes in temperature like moving from a cold to a hot environment. Other triggers arise from food and drink that cause flushing such as alcohol, hot caffeine drinks (tea, coffee), and certain spicy foods. Rosacea can even be triggered by blushing with embarrassment. The scientists found that people with rosacea have high levels of the anti microbial peptide cathelicidin in their skin and the proteins this produces are different to those found in people who do not have the disease. Another important contributor is an enzyme called stratum corneum tryptic enzyme (SCTE). Gallo said: "It's like having lots of gasoline and a match." He and his team found that over-production of two inflammatory proteins (<--염증관련 단백질..)eads to high levels of a third protein that causes rosacea symptoms, "A trifecta of unfortunate factors in people with rosacea," said Gallo. They first noticed in the laboratory that anti-microbial peptides, small proteins of the immune system, caused the same redness of skin, bumps, pimples and spider veins seen in rosacea patients. And these peptides were triggered by the same things as rosacea. When they looked at patients with rosacea they found that every one of them had more of these peptides than normal. The surprising thing about the discovery is that the precursor to the peptides they found is another peptide, cathelicidin, which is thought to protect the skin from infection. A range of other diseases with skin inflammation is linked to a shortage of cathelicidin. But in rosacea patients the scientists found the opposite: too much cathelicidin, altough it was a different type to that found in people who do not have the disease. They also found that patients with rosacea had too much SCTE, which converts cathelicidin into the immune system peptides that lead to rosacea. So they tested the effect of the two substances by injecting laboratory mice with the cathelicidin peptides found in rosacea, adding SCTE, and increasing their protease activity by switching off a gene (Spink5, the protease inhibitor). Each of these increased inflammation of the skin. They also tested the role that cathelicidin plays in helping inflammation caused by SCTE by deleting the gene that codes for it in mice, the Camp gene. Gallo explained that: "Too much SCTE and too much cathelicidin leads to the abnormal peptides that cause the symptoms of this disease." <---요두가지 단백질이 원인일거 같다는.. He also explained why antibiotics sometimes work in treating rosacea, even though the condition is not caused by bacteria: "Antibiotics tend to alleviate the symptoms of rosacea in patients because some of them work to inhibit these enzymes. Our findings may modify the therapeutic approach to treating rosacea, since bacteria aren't the right target."--> '주사 '(rosacea) 에 항생제를 쓰긴썼는데 균때문이 아닌데도 좋아졌던 이유설명..

오보라고 생각됩니다. KBS 에서 질환명을 잘못 안게 원인인것 같습니다...--;;

[남들피부처럼만되라]

헐~ 외계어 잔뜩~ 어지럽네여 ㅎ;; 아무튼 좋은정보 ㄳ 치료하는 시술 잘됬으면 하네여 거짓말이면 엉덩이 뿅하고 차버릴꺼임.ㅋ

[흉터지우개]

@.@ 거짓말이라뇨..--; 사람마다 반응이 다를수야 있지요..필요한 횟수가 다를 수 있구요. 모든 시술이 그렇습니다. 흉터시술에서 적절한 목표설정이 중요하지요..흉터가 싹 없어지진 않습닞다. 흉터가 차올라 얕아진것이지.