Adult Stem Cells Injected in Heart Boost Blood Flow (Update1)
By Rob Waters
May 19 (Bloomberg) -- Patients with clogged arteries and
severe chest pain who were injected with stem cells from their
own bone marrow had a small improvement in blood flow and the
pumping ability of their hearts, along with an easing of pain,
researchers found.
Doctors in the Netherlands drew bone marrow from the hips
of patients in the study. After isolating the stem cells, they
injected them back into the patients’ hearts and monitored their
progress. The results were published today in the Journal of the
American Medical Association.
Researchers are pursuing the use of different kinds of stem
cells to treat a range of conditions, and several thousand heart
patients have been treated with adult stem cells, those found in
mature organs. While some cardiologists originally hoped bone
marrow cells might generate new heart muscle to replace damaged
tissue, that hasn’t been found to occur, said Warren Sherman, a
cardiologist at Columbia University in New York.
“The focus has shifted,” said Sherman, in a telephone
interview today. “Cardiologists are now hoping that bone marrow
stem cells can promote the growth of new blood vessels and
improve the quality of life and level of chest pain patients
have.”
The new study, in 50 patients, showed that adult stem cells
can improve blood flow and ease chest pain, Sherman said.
In the study, half of the patients got their own stem cells
and the others got a simulated treatment. The cardiologists used
a catheter, a thin wire threaded through their arteries that
also carried a small camera to guide the injections.
Less Pain
The key finding in Sherman’s view was that the treated
patients reported greater easing of their chest pain at three
months and six months after the procedure than did the placebo
patients. On a scale of 0 to 100, the patients who got their own
stem cells improved from 56 to 69 after six months, while the
placebo patients went from 57 to 64.
“Most patients are looking for relief of chest pain more
than improvement in ventricular function,” or pumping action,
Sherman said.
He said to truly demonstrate effectiveness of bone marrow
cells, larger studies will need to be completed.
To contact the reporter on this story:
Rob Waters in San Francisco at
rwaters5@bloomberg.net.
Last Updated: May 19, 2009 16:39 EDT