포포나무의 새로운 효능(간 디스토마)

<P>먼저 원문을 올려봅니다...</P> <P>몇가지 포포나무 속 식물의 알콜추출물을 비교해본 자료입니다.</P> <P>그중엔  포포나무의 알콜 추출물이 포함되어있네요.</P> <P>간디스토마의 시험관적 임상에서효과가 나타나네요...</P> <P> </P> <DIV class=rprt_all> <DIV class="rprt abstract"> <DIV class=cit><A aria-expanded=false title="Parasitology research." role=button href="http://www.ncbi.nlm.nih.gov/pubmed/21562762#" abstractLink="yes" alsec="jour" alterm="Parasitol Res." jQuery17103726564939677903="42" _sg="true"><U><FONT color=#0066cc>Parasitol Res.</FONT></U></A> 2011 Dec;109(6):1585-92. Epub 2011 May 12.</DIV> <H1>In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, <SPAN class=highlight>Asimina</SPAN> triloba, and Fumaria officinalis: trematocidal plant alcoholic extracts.</H1> <DIV class=auths><A href="http://www.ncbi.nlm.nih.gov/pubmed?term=Ferreira%20JF%5BAuthor%5D&cauthor=true&cauthor_uid=21562762" _sg="true"><U><FONT color=#0066cc>Ferreira JF</FONT></U></A>, <A href="http://www.ncbi.nlm.nih.gov/pubmed?term=Peaden%20P%5BAuthor%5D&cauthor=true&cauthor_uid=21562762" _sg="true"><U><FONT color=#0066cc>Peaden P</FONT></U></A>, <A href="http://www.ncbi.nlm.nih.gov/pubmed?term=Keiser%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21562762" _sg="true"><U><FONT color=#0066cc>Keiser J</FONT></U></A>.</DIV> <DIV class=aff> <H3 class=label>Source</H3> <P>USDA-ARS, Appalachian Farming Systems Research Center, 1224 Airport Rd., Beaver, WV 25813, USA. Jorge.Ferreira@ars.usda.gov</P></DIV> <DIV class=abstr> <H3>Abstract</H3> <P>Trematode infections negatively affect human and livestock health, and threaten global food safety. The only approved human anthelmintics for trematodiasis are triclabendazole and praziquantel with no alternative drugs in sight. We tested six crude plant extracts against adult Schistosoma mansoni, Fasciola hepatica, and Echinostoma caproni in vitro. Mortality was best achieved by ethanolic extracts of Artemisia annua (sweet Annie), <SPAN class=highlight>Asimina</SPAN> triloba (paw-paw), and Artemisia absinthium (wormwood) which, at 2 mg/mL, killed S. mansoni and E. caproni in 20 h or less (except for wormwood), F. hepatica between 16 and 23 h (sweet Annie), or 40 h (paw-paw). Some extracts were active at 0.2 mg/mL and 20 μg/mL, although more time was required to kill trematodes. However, aqueous A. annua and methanol extracts of Fumaria officinalis had no activity. Chromatographic analysis of the three best extracts established that A. annua and A. triloba extracts contained bioactive artemisinin and <SPAN class=highlight>acetogenins</SPAN> (asimicin and bullatacin), respectively. The anthelmintic activity of our extracts at such low doses indicates that their anthelmintic activity deserves further testing as natural alternative controls for parasites of both animals and humans. Our results also support recent evidence that synergistic effects of multiple bioactive compounds present in crude plant extracts is worth exploring.</P></DIV> <DIV class=aux> <DIV class=resc> <DL class=rprtid> <DT>PMID: <DD>21562762 <DD>[PubMed - indexed for MEDLINE] <DD></DD></DL></DIV> <DIV class=links></DIV></DIV></DIV></DIV>